(37 nodes) Regulation of steroid biosynthetic process network (Danio rerio)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	LOC100331467	START domain-containing protein. (277 aa)
	snai2	Snail homolog 2 (Drosophila). (257 aa)
	apoba	Apolipoprotein Ba. (4418 aa)
	fgf1b	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa)
	srebf1	Sterol regulatory element-binding transcription factor 1. (879 aa)
	srebf2	Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity). (1095 aa)
	abcg1	ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
	sirt1	Sirtuin 1. (710 aa)
	nr1d4a	Nuclear receptor subfamily 1, group D, member 4a. (570 aa)
	dkk3b	Dickkopf WNT-signaling pathway inhibitor 3b. (283 aa)
	abcg4b	ATP-binding cassette, sub-family G (WHITE), member 4b. (644 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
	nr1d1	Nuclear receptor subfamily 1, group d, member 1. (637 aa)
	nr0b1	Nuclear receptor subfamily 0, group B, member 1. (302 aa)
	tnfb	Tumor necrosis factor b (TNF superfamily, member 2). (242 aa)
	lepa	Putative leptin. (166 aa)
	cyp19a1a	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
	rusc1	RUN and SH3 domain-containing 1. (610 aa)
	abcg4a	ATP-binding cassette, sub-family G (WHITE), member 4a. (641 aa)
	podn	Podocan. (530 aa)
	scap	SREBF chaperone. (1245 aa)
	h6pd	Hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase). (791 aa)
	armc5	Armadillo repeat-containing 5. (1218 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (117 aa)
	sf1	Splicing factor 1. (663 aa)
	fgf19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	stard4	StAR-related lipid transfer (START) domain-containing 4. (198 aa)
	dkk3a	Dickkopf WNT-signaling pathway inhibitor 3a. (293 aa)
	LOC110438068	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
	dgkab	Diacylglycerol kinase. (727 aa)
	fgfr4	Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
	ENSDARP00000146183	Si:ch211-204c21.1. (697 aa)
	star	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity). (285 aa)
	dab2	DAB adaptor protein 2. (589 aa)
	asah1b	N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family. (395 aa)
	asah1a	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family. (390 aa)
	fgf1a	Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSDARP00000146183	apoba	ENSDARP00000146183	ENSDARP00000062792	Si:ch211-204c21.1.	Apolipoprotein Ba.	0.512
LOC110438068	cga	ENSDARP00000141292	ENSDARP00000127496	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.545
abcg1	apoba	ENSDARP00000087241	ENSDARP00000062792	ATP-binding cassette, sub-family G (WHITE), member 1.	Apolipoprotein Ba.	0.452
abcg1	srebf1	ENSDARP00000087241	ENSDARP00000087097	ATP-binding cassette, sub-family G (WHITE), member 1.	Sterol regulatory element-binding transcription factor 1.	0.658
abcg1	srebf2	ENSDARP00000087241	ENSDARP00000087122	ATP-binding cassette, sub-family G (WHITE), member 1.	Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).	0.844
abcg4a	abcg4b	ENSDARP00000116517	ENSDARP00000102351	ATP-binding cassette, sub-family G (WHITE), member 4a.	ATP-binding cassette, sub-family G (WHITE), member 4b.	0.902
abcg4b	abcg4a	ENSDARP00000102351	ENSDARP00000116517	ATP-binding cassette, sub-family G (WHITE), member 4b.	ATP-binding cassette, sub-family G (WHITE), member 4a.	0.902
apoba	ENSDARP00000146183	ENSDARP00000062792	ENSDARP00000146183	Apolipoprotein Ba.	Si:ch211-204c21.1.	0.512
apoba	abcg1	ENSDARP00000062792	ENSDARP00000087241	Apolipoprotein Ba.	ATP-binding cassette, sub-family G (WHITE), member 1.	0.452
apoba	srebf1	ENSDARP00000062792	ENSDARP00000087097	Apolipoprotein Ba.	Sterol regulatory element-binding transcription factor 1.	0.570
apoba	srebf2	ENSDARP00000062792	ENSDARP00000087122	Apolipoprotein Ba.	Processed sterol regulatory element-binding protein 2; Transcriptional activator required for lipid homeostasis. May regulate transcription of the LDL receptor gene as well as the cholesterol and fatty acid synthesis pathways. Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes (By similarity).	0.643
apoba	tnfb	ENSDARP00000062792	ENSDARP00000010728	Apolipoprotein Ba.	Tumor necrosis factor b (TNF superfamily, member 2).	0.408
asah1a	asah1b	ENSDARP00000007893	ENSDARP00000040433	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family.	0.905
asah1b	asah1a	ENSDARP00000040433	ENSDARP00000007893	N-acylsphingosine amidohydrolase (acid ceramidase) 1b; Belongs to the acid ceramidase family.	N-acylsphingosine amidohydrolase (acid ceramidase) 1a; Belongs to the acid ceramidase family.	0.905
cga	LOC110438068	ENSDARP00000127496	ENSDARP00000141292	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.545
cga	cyp19a1a	ENSDARP00000127496	ENSDARP00000111604	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	0.490
cyp19a1a	cga	ENSDARP00000111604	ENSDARP00000127496	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family.	0.490
cyp19a1a	lepa	ENSDARP00000111604	ENSDARP00000111103	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Putative leptin.	0.404
cyp19a1a	nr0b1	ENSDARP00000111604	ENSDARP00000105523	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Nuclear receptor subfamily 0, group B, member 1.	0.854
cyp19a1a	star	ENSDARP00000111604	ENSDARP00000023907	Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone (By similarity).	0.900

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