STRINGSTRING
clu clu lrp5 lrp5 LOC100334178 LOC100334178 trim8a trim8a adcy1b adcy1b tnfrsf11a tnfrsf11a LOC100332300 LOC100332300 tirap tirap crtc2 crtc2 crtc1a crtc1a sox19a sox19a malt1 malt1 cd40lg cd40lg il10 il10 mbtps2 mbtps2 edn1 edn1 sox2 sox2 flot1b flot1b wnt2ba wnt2ba eda eda sox1a sox1a traf1 traf1 adcy1a adcy1a clul1 clul1 tnfsf11 tnfsf11 ar ar ppargc1a ppargc1a card9 card9 adcy8 adcy8 stk36 stk36 rnf220a rnf220a trim62.1 trim62.1 trim8b trim8b kdm1a kdm1a rps6ka5 rps6ka5 plpp3 plpp3 ddit3 ddit3 jupb jupb nts nts cops5 cops5 neurog1 neurog1 arhgef2 arhgef2 zgc:77151 zgc:77151 srfa srfa crtc1b crtc1b sox3 sox3 crtc3 crtc3 irak3 irak3 rps6ka4 rps6ka4 psma6l psma6l prkcz prkcz tnfrsf19 tnfrsf19 arhgef1a arhgef1a sox19b sox19b fank1 fank1 traf4b traf4b arid5b arid5b rbck1 rbck1 abrab abrab wnt2bb wnt2bb traf2a traf2a grem1a grem1a prdx3 prdx3 rnf25 rnf25 traf6 traf6 pkz pkz psma6b psma6b jupa jupa sox1b sox1b tnfa tnfa sav1 sav1 malt2 malt2 unm_sa808 unm_sa808 mtdhb mtdhb pink1 pink1 ripk1l ripk1l smo smo chuk chuk fosl1a fosl1a tnfb tnfb psma6a psma6a pprc1 pprc1 LOC108179742 LOC108179742 JMY JMY ENSDARP00000151894 ENSDARP00000151894 cytl1 cytl1 rnf220b rnf220b ripk4 ripk4 LOC110437957 LOC110437957 ENSDARP00000145932 ENSDARP00000145932 Reln Reln terf2ip terf2ip traf2b traf2b flot1a flot1a ENSDARP00000142835 ENSDARP00000142835 adgrg1-2 adgrg1-2 trappc9 trappc9 il1b il1b ep300a ep300a card14 card14 fzd4 fzd4 cib1 cib1 trim32 trim32 lrp6 lrp6 ripk2 ripk2 srfb srfb LOC110440113 LOC110440113 eif2ak2 eif2ak2 ppargc1b ppargc1b relt relt whamm whamm appa appa TRAPPC9 TRAPPC9 taf12 taf12 E7FC63_DANRE E7FC63_DANRE abraa abraa nod1 nod1 card11 card11 ep300b ep300b dhx33 dhx33 X1WD23_DANRE X1WD23_DANRE grem2a grem2a ndp ndp nod2 nod2 fosl1b fosl1b adgrf6-2 adgrf6-2 cthl cthl B0S5K1_DANRE B0S5K1_DANRE dhx9 dhx9 rgcc rgcc malt3 malt3 irak1 irak1 ikbkb ikbkb cth cth F6NWN8_DANRE F6NWN8_DANRE trim37 trim37 nkx3-1 nkx3-1 rwdd1 rwdd1 cd40 cd40 Q5RHR2_DANRE Q5RHR2_DANRE adgrf7 adgrf7 trim62.2 trim62.2 mtdha mtdha ripk3 ripk3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cluClusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (449 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1615 aa)
LOC100334178Uncharacterized protein. (981 aa)
trim8aTripartite motif-containing 8a. (567 aa)
adcy1bAdenylate cyclase 1b; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (834 aa)
tnfrsf11aTumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
tirapToll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
crtc2CREB-regulated transcription coactivator 2. (759 aa)
crtc1aCREB-regulated transcription coactivator 1a. (533 aa)
sox19aTranscription factor Sox-19a; Transcriptional activator. (297 aa)
malt1MALT paracaspase 1. (768 aa)
cd40lgCD40 ligand; Belongs to the tumor necrosis factor family. (260 aa)
il10Interleukin-10. (180 aa)
mbtps2Membrane-bound transcription factor peptidase, site 2. (494 aa)
edn1Endothelin 1. (188 aa)
sox2Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa)
flot1bFlotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (425 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
edaEctodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
sox1aTranscription factor Sox-1a; Transcriptional activator. (336 aa)
traf1TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
adcy1aAdenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1114 aa)
clul1Clusterin; Belongs to the clusterin family. (466 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
arAndrogen receptor. (868 aa)
ppargc1aPeroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (859 aa)
card9Caspase recruitment domain family, member 9. (534 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (892 aa)
stk36Serine/threonine kinase 36 (fused homolog, Drosophila). (1231 aa)
rnf220aRing finger protein 220a. (307 aa)
trim62.1Tripartite motif-containing 62, tandem duplicate 1. (475 aa)
trim8bSimilar to tripartite motif-containing 8. (564 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa)
rps6ka5Ribosomal protein S6 kinase. (802 aa)
plpp3Phospholipid phosphatase 3. (312 aa)
ddit3DNA-damage-inducible transcript 3. (242 aa)
jupbJunction plakoglobin b. (726 aa)
ntsNeurotensin. (165 aa)
cops5COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex; Belon [...] (334 aa)
neurog1Neurogenin-1; Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specificati [...] (208 aa)
arhgef2Rho/rac guanine nucleotide exchange factor (GEF) 2. (872 aa)
zgc:77151Zgc:77151. (856 aa)
srfaSerum response factor a. (539 aa)
crtc1bCREB-regulated transcription coactivator 1b. (583 aa)
sox3Transcription factor Sox-3; Transcriptional activator. (300 aa)
crtc3CREB-regulated transcription coactivator 3. (535 aa)
irak3Interleukin-1 receptor-associated kinase 3. (630 aa)
rps6ka4Ribosomal protein S6 kinase. (745 aa)
psma6lProteasome subunit alpha type. (252 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
tnfrsf19Tumor necrosis factor receptor superfamily, member 19. (356 aa)
arhgef1aRho guanine nucleotide exchange factor (GEF) 1a. (935 aa)
sox19bTranscription factor Sox-19b; Transcriptional activator. (293 aa)
fank1Fibronectin type III and ankyrin repeat domains 1. (336 aa)
traf4bTNF receptor-associated factor. (478 aa)
arid5bAT-rich interactive domain-containing protein 5B; Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes (By similarity). (1050 aa)
rbck1RanBP-type and C3HC4-type zinc finger-containing protein 1. (515 aa)
abrabActin-binding Rho-activating protein b. (359 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
grem1aGremlin. (177 aa)
prdx3Peroxiredoxin 3. (281 aa)
rnf25Ring finger protein 25. (513 aa)
traf6TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
pkzProtein kinase-containing Z-DNA-binding domains. (511 aa)
psma6bProteasome subunit alpha type. (246 aa)
jupaJunction plakoglobin a. (729 aa)
sox1bTranscription factor Sox-1b; Transcriptional activator. (340 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
sav1Salvador family WW domain-containing protein 1. (397 aa)
malt2MALT paracaspase 2. (806 aa)
unm_sa808Un-named sa808. (281 aa)
mtdhbMetadherin b. (525 aa)
pink1PTEN-induced kinase 1. (574 aa)
ripk1lReceptor (TNFRSF)-interacting serine-threonine kinase 1,-like. (661 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
chukInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
fosl1aFOS-like 1, AP-1 transcription factor subunit a. (346 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
psma6aProteasome subunit alpha type. (246 aa)
pprc1PPARG-related coactivator 1. (1220 aa)
LOC108179742Uncharacterized protein. (261 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (711 aa)
ENSDARP00000151894Uncharacterized protein. (501 aa)
cytl1Cytokine like 1. (145 aa)
rnf220bRing finger protein 220b. (362 aa)
ripk4Receptor-interacting serine-threonine kinase 4. (835 aa)
LOC110437957CARD domain-containing protein. (201 aa)
ENSDARP00000145932TORC_N domain-containing protein. (72 aa)
RelnReelin domain-containing protein. (259 aa)
terf2ipTelomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (644 aa)
traf2bTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
flot1aFlotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (438 aa)
ENSDARP00000142835Si:dkey-23i12.7. (158 aa)
adgrg1-2Adhesion G protein-coupled receptor G1. (513 aa)
trappc9Trafficking protein particle complex 9. (133 aa)
il1bInterleukin-1. (284 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
card14Caspase recruitment domain family, member 14. (985 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (523 aa)
cib1Calcium and integrin-binding 1 (calmyrin). (188 aa)
trim32Tripartite motif-containing 32. (663 aa)
lrp6Low density lipoprotein receptor-related protein 6. (935 aa)
ripk2Receptor-interacting serine-threonine kinase 2. (457 aa)
srfbSerum response factor b. (260 aa)
LOC110440113Si:dkey-93h22.8. (958 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
ppargc1bPeroxisome proliferator-activated receptor gamma, coactivator 1 beta. (847 aa)
reltRELT TNF receptor. (401 aa)
whammUncharacterized protein. (621 aa)
appaAmyloid beta (A4) precursor protein a. (194 aa)
TRAPPC9Si:dkey-218f9.10. (995 aa)
taf12TAF12 RNA polymerase II, TATA box-binding protein (TBP)-associated factor. (162 aa)
E7FC63_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1183 aa)
abraaActin-binding Rho-activating protein a. (347 aa)
nod1Nucleotide-binding oligomerization domain-containing 1. (903 aa)
card11Caspase recruitment domain family, member 11. (1110 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
dhx33DEAH (Asp-Glu-Ala-His) box polypeptide 33. (680 aa)
X1WD23_DANRESi:ch211-108d22.2. (1739 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
ndpNorrin cystine knot growth factor NDP. (138 aa)
nod2Nucleotide-binding oligomerization domain-containing 2. (980 aa)
fosl1bFOS-like 1, AP-1 transcription factor subunit b. (200 aa)
adgrf6-2Adhesion G protein-coupled receptor F6; Belongs to the G-protein coupled receptor 2 family. (937 aa)
cthlCystathionase (cystathionine gamma-lyase),-like. (404 aa)
B0S5K1_DANRESi:dkey-181m9.8. (633 aa)
dhx9DEAH (Asp-Glu-Ala-His) box helicase 9. (1271 aa)
rgccRegulator of cell cycle. (128 aa)
malt3MALT paracaspase 3. (627 aa)
irak1Interleukin-1 receptor-associated kinase 1. (686 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
cthCystathionase (cystathionine gamma-lyase). (404 aa)
F6NWN8_DANRESi:dkey-29b11.3. (173 aa)
trim37Tripartite motif-containing 37. (957 aa)
nkx3-1NK3 homeobox 1. (214 aa)
rwdd1RWD domain-containing 1. (240 aa)
cd40CD40 molecule, TNF receptor superfamily member 5. (286 aa)
Q5RHR2_DANREAdenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1187 aa)
adgrf7Adhesion G protein-coupled receptor F7; Belongs to the G-protein coupled receptor 2 family. (504 aa)
trim62.2Tripartite motif-containing 62, tandem duplicate 2. (341 aa)
mtdhaMetadherin a. (543 aa)
ripk3Receptor-interacting serine-threonine kinase 3. (361 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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