(75 nodes) Positive regulation of NF-kappaB transcription factor activity network (Danio rerio)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	cd40lg	CD40 ligand; Belongs to the tumor necrosis factor family. (260 aa)
	tnfa	Tumor necrosis factor a (TNF superfamily, member 2). (234 aa)
	psma6b	Proteasome subunit alpha type. (246 aa)
	pkz	Protein kinase-containing Z-DNA-binding domains. (511 aa)
	traf6	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction. (542 aa)
	rnf25	Ring finger protein 25. (513 aa)
	prdx3	Peroxiredoxin 3. (281 aa)
	grem1a	Gremlin. (177 aa)
	traf2a	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
	rbck1	RanBP-type and C3HC4-type zinc finger-containing protein 1. (515 aa)
	arhgef1a	Rho guanine nucleotide exchange factor (GEF) 1a. (935 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa)
	psma6l	Proteasome subunit alpha type. (252 aa)
	rps6ka4	Ribosomal protein S6 kinase. (745 aa)
	irak3	Interleukin-1 receptor-associated kinase 3. (630 aa)
	arhgef2	Rho/rac guanine nucleotide exchange factor (GEF) 2. (872 aa)
	nts	Neurotensin. (165 aa)
	rps6ka5	Ribosomal protein S6 kinase. (802 aa)
	trim8b	Similar to tripartite motif-containing 8. (564 aa)
	trim62.1	Tripartite motif-containing 62, tandem duplicate 1. (475 aa)
	card9	Caspase recruitment domain family, member 9. (534 aa)
	ar	Androgen receptor. (868 aa)
	tnfsf11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
	traf1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (551 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (359 aa)
	flot1b	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (425 aa)
	malt1	MALT paracaspase 1. (768 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
	LOC100332300	Gremlin 1a, DAN family BMP antagonist. (177 aa)
	tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a, NFKB activator. (574 aa)
	LOC100334178	Uncharacterized protein. (981 aa)
	trim8a	Tripartite motif-containing 8a. (567 aa)
	ripk3	Receptor-interacting serine-threonine kinase 3. (361 aa)
	mtdha	Metadherin a. (543 aa)
	trim62.2	Tripartite motif-containing 62, tandem duplicate 2. (341 aa)
	cd40	CD40 molecule, TNF receptor superfamily member 5. (286 aa)
	trim37	Tripartite motif-containing 37. (957 aa)
	cth	Cystathionase (cystathionine gamma-lyase). (404 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (779 aa)
	irak1	Interleukin-1 receptor-associated kinase 1. (686 aa)
	malt3	MALT paracaspase 3. (627 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1271 aa)
	B0S5K1_DANRE	Si:dkey-181m9.8. (633 aa)
	cthl	Cystathionase (cystathionine gamma-lyase),-like. (404 aa)
	nod2	Nucleotide-binding oligomerization domain-containing 2. (980 aa)
	grem2a	Gremlin 2, DAN family BMP antagonist a. (195 aa)
	X1WD23_DANRE	Si:ch211-108d22.2. (1739 aa)
	dhx33	DEAH (Asp-Glu-Ala-His) box polypeptide 33. (680 aa)
	ep300b	E1A-binding protein p300 b. (2615 aa)
	card11	Caspase recruitment domain family, member 11. (1110 aa)
	nod1	Nucleotide-binding oligomerization domain-containing 1. (903 aa)
	TRAPPC9	Si:dkey-218f9.10. (995 aa)
	appa	Amyloid beta (A4) precursor protein a. (194 aa)
	eif2ak2	Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (457 aa)
	trim32	Tripartite motif-containing 32. (663 aa)
	cib1	Calcium and integrin-binding 1 (calmyrin). (188 aa)
	card14	Caspase recruitment domain family, member 14. (985 aa)
	ep300a	E1A-binding protein p300 a. (2679 aa)
	il1b	Interleukin-1. (284 aa)
	trappc9	Trafficking protein particle complex 9. (133 aa)
	adgrg1-2	Adhesion G protein-coupled receptor G1. (513 aa)
	flot1a	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (438 aa)
	traf2b	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	terf2ip	Telomeric repeat-binding factor 2-interacting protein 1; Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'- TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similar [...] (644 aa)
	LOC110437957	CARD domain-containing protein. (201 aa)
	ripk4	Receptor-interacting serine-threonine kinase 4. (835 aa)
	ENSDARP00000151894	Uncharacterized protein. (501 aa)
	LOC108179742	Uncharacterized protein. (261 aa)
	malt2	MALT paracaspase 2. (806 aa)
	unm_sa808	Un-named sa808. (281 aa)
	mtdhb	Metadherin b. (525 aa)
	chuk	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (758 aa)
	tnfb	Tumor necrosis factor b (TNF superfamily, member 2). (242 aa)
	psma6a	Proteasome subunit alpha type. (246 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0S5K1_DANRE	rbck1	ENSDARP00000119081	ENSDARP00000047443	Si:dkey-181m9.8.	RanBP-type and C3HC4-type zinc finger-containing protein 1.	0.862
B0S5K1_DANRE	tnfb	ENSDARP00000119081	ENSDARP00000010728	Si:dkey-181m9.8.	Tumor necrosis factor b (TNF superfamily, member 2).	0.810
ENSDARP00000151894	il1b	ENSDARP00000151894	ENSDARP00000140751	Uncharacterized protein.	Interleukin-1.	0.979
ENSDARP00000151894	irak1	ENSDARP00000151894	ENSDARP00000118154	Uncharacterized protein.	Interleukin-1 receptor-associated kinase 1.	0.711
ENSDARP00000151894	irak3	ENSDARP00000151894	ENSDARP00000067130	Uncharacterized protein.	Interleukin-1 receptor-associated kinase 3.	0.521
ENSDARP00000151894	traf6	ENSDARP00000151894	ENSDARP00000036715	Uncharacterized protein.	TNF receptor-associated factor 6; E3 ubiquitin-protein ligase that mediates ubiquitination of proteins. Adapter protein that seems to play a role in signal transduction.	0.793
LOC100334178	chuk	ENSDARP00000109107	ENSDARP00000013115	Uncharacterized protein.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.661
LOC100334178	ikbkb	ENSDARP00000109107	ENSDARP00000117685	Uncharacterized protein.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.673
LOC100334178	rbck1	ENSDARP00000109107	ENSDARP00000047443	Uncharacterized protein.	RanBP-type and C3HC4-type zinc finger-containing protein 1.	0.983
LOC100334178	ripk2	ENSDARP00000109107	ENSDARP00000134516	Uncharacterized protein.	Receptor-interacting serine-threonine kinase 2.	0.910
LOC100334178	tnfb	ENSDARP00000109107	ENSDARP00000010728	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.810
LOC100334178	tnfsf11	ENSDARP00000109107	ENSDARP00000089126	Uncharacterized protein.	TNF superfamily member 11; Belongs to the tumor necrosis factor family.	0.499
LOC100334178	traf2a	ENSDARP00000109107	ENSDARP00000043465	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.917
LOC100334178	traf2b	ENSDARP00000109107	ENSDARP00000144196	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.917
LOC108179742	rbck1	ENSDARP00000154092	ENSDARP00000047443	Uncharacterized protein.	RanBP-type and C3HC4-type zinc finger-containing protein 1.	0.862
LOC108179742	tnfb	ENSDARP00000154092	ENSDARP00000010728	Uncharacterized protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.810
LOC110437957	X1WD23_DANRE	ENSDARP00000146005	ENSDARP00000128120	CARD domain-containing protein.	Si:ch211-108d22.2.	0.420
LOC110437957	nod1	ENSDARP00000146005	ENSDARP00000129412	CARD domain-containing protein.	Nucleotide-binding oligomerization domain-containing 1.	0.453
LOC110437957	nod2	ENSDARP00000146005	ENSDARP00000124380	CARD domain-containing protein.	Nucleotide-binding oligomerization domain-containing 2.	0.420
LOC110437957	tnfb	ENSDARP00000146005	ENSDARP00000010728	CARD domain-containing protein.	Tumor necrosis factor b (TNF superfamily, member 2).	0.425

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