STRINGSTRING
rif1 rif1 kdm4ab kdm4ab dnmt1 dnmt1 prdm12b prdm12b myb myb kdm1a kdm1a jarid2a jarid2a kdm4c kdm4c jarid2b jarid2b sirt1 sirt1 ehmt1a ehmt1a atrx atrx mecp2 mecp2 ehmt1b ehmt1b kdm4aa kdm4aa ehmt2 ehmt2 kdm4b kdm4b atrxl atrxl
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rif1Replication timing regulatory factor 1. (2392 aa)
kdm4abLysine (K)-specific demethylase 4A, genome duplicate b. (1045 aa)
dnmt1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1500 aa)
prdm12bPR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (366 aa)
mybV-myb avian myeloblastosis viral oncogene homolog. (641 aa)
kdm1aLysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (833 aa)
jarid2aJumonji, AT-rich interactive domain 2a. (1171 aa)
kdm4cLysine (K)-specific demethylase 4C. (1482 aa)
jarid2bProtein Jumonji; Regulator of histone methyltransferase complexes that plays an essential role in embryonic development. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone [...] (1319 aa)
sirt1Sirtuin 1. (710 aa)
ehmt1aEuchromatic histone-lysine N-methyltransferase 1a. (1059 aa)
atrxATRX chromatin remodeler. (2013 aa)
mecp2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (524 aa)
ehmt1bEuchromatic histone-lysine N-methyltransferase 1b. (1278 aa)
kdm4aaLysine (K)-specific demethylase 4A, genome duplicate a. (2012 aa)
ehmt2Euchromatic histone-lysine N-methyltransferase 2. (1167 aa)
kdm4bLysine (K)-specific demethylase 4B. (1134 aa)
atrxlATRX chromatin remodeler,-like. (1760 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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