STRINGSTRING
tmod4 tmod4 csrp1a csrp1a myod1 myod1 klhl41b klhl41b nkx2.5 nkx2.5 chrnd chrnd tmod2 tmod2 qki2 qki2 hsp90aa1.1 hsp90aa1.1 orai1b orai1b unc45b unc45b naca naca hsp90aa1.2 hsp90aa1.2 tcap tcap vangl2 vangl2 tnnt2c tnnt2c csrp1b csrp1b myoz2a myoz2a ache ache shhb shhb myoz1a myoz1a adprhl1 adprhl1 srfa srfa LOC101887017 LOC101887017 ldb3a ldb3a bves bves ihha ihha ihhb ihhb megf11 megf11 lmod3 lmod3 klhl41a klhl41a tnnt3a tnnt3a lrrc39 lrrc39 mylk3 mylk3 tmod1 tmod1 lmod1b lmod1b nrap nrap myf5 myf5 csrp2 csrp2 lmod2b lmod2b neb neb tnnt2d tnnt2d tnnt3b tnnt3b F1QHP3_DANRE F1QHP3_DANRE myoz2b myoz2b tnnt2a tnnt2a shha shha flii flii tnnt2b tnnt2b LOC108190739 LOC108190739 tpcn2 tpcn2 tnnt2e tnnt2e srfb srfb LOC100334697 LOC100334697 csrp3 csrp3 qkia qkia dusp27 dusp27 tnnt1 tnnt1 WDR1 WDR1 qkib qkib megf10 megf10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tmod4Tropomodulin 4 (Muscle). (343 aa)
csrp1aCysteine and glycine-rich protein 1a. (192 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
klhl41bKelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa)
nkx2.5NK2 homeobox 5. (314 aa)
chrndCholinergic receptor, nicotinic, delta (muscle). (518 aa)
tmod2Tropomodulin 2. (344 aa)
qki2Protein quaking-B; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (319 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
orai1bCalcium release-activated calcium channel protein 1; Ca(2+) release-activated Ca(2+) (CRAC) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores; Belongs to the Orai family. (222 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
nacaNascent polypeptide-associated complex subunit alpha; May promote appropriate targeting of ribosome-nascent polypeptide complexes. (215 aa)
hsp90aa1.2Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (734 aa)
tcapTitin-cap (telethonin). (179 aa)
vangl2Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
csrp1bCysteine and glycine-rich protein 1b. (192 aa)
myoz2aMyozenin 2a. (264 aa)
acheAcetylcholinesterase; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. (634 aa)
shhbTiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. (416 aa)
myoz1aZgc:77785 protein. (319 aa)
adprhl1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (350 aa)
srfaSerum response factor a. (539 aa)
LOC101887017Leiomodin 1a (smooth muscle). (645 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
ihhaHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
ihhbIndian hedgehog B protein C-product; Intercellular signal essential for a variety of patterning events during development. Signal produced by the notochord that induces somite patterning and muscle pioneer differentiation. (412 aa)
megf11Multiple EGF-like-domains 11. (1114 aa)
lmod3Leiomodin-3; Essential for the organization of sarcomeric thin filaments in skeletal muscle; Belongs to the tropomodulin family. (670 aa)
klhl41aKelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa)
tnnt3aTroponin T type 3a (skeletal, fast). (230 aa)
lrrc39Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
tmod1Tropomodulin 1. (356 aa)
lmod1bLeiomodin 1b (smooth muscle). (671 aa)
nrapNebulin-related-anchoring protein. (1861 aa)
myf5Myogenic factor. (237 aa)
csrp2Cysteine and glycine-rich protein 2. (193 aa)
lmod2bLeiomodin 2 (cardiac) b. (604 aa)
nebNebulin. (6177 aa)
tnnt2dTroponin T2d, cardiac. (241 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
F1QHP3_DANRECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (543 aa)
myoz2bMyozenin 2b. (226 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
fliiFLII actin-remodeling protein. (1259 aa)
tnnt2bTroponin T type 2b (cardiac). (233 aa)
LOC108190739Myozenin-2-like. (122 aa)
tpcn2Two pore calcium channel protein 2; Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction (By similarity). (774 aa)
tnnt2eNovel slow skeletal troponin T family protein. (285 aa)
srfbSerum response factor b. (260 aa)
LOC100334697Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (576 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
qkiaProtein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa)
dusp27Inactive dual specificity phosphatase 27; Required for myofiber maturation. (1100 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
WDR1WD repeat domain 1. (606 aa)
qkibProtein quaking-B. (347 aa)
megf10Multiple epidermal growth factor-like domains protein 10; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells (By similarity). Essential factor in the regulation of muscle development including myogenesis (Ref.4). Likely plays a key role in muscle cell proliferation, adhesion and motility. May control the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. (1142 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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