STRINGSTRING
nkx2.5 nkx2.5 tcap tcap cyp26a1 cyp26a1 adprhl1 adprhl1 lrrc10 lrrc10 srfa srfa zmpste24 zmpste24 opa1 opa1 map2k4b map2k4b maml1 maml1 mylk3 mylk3 mtor mtor map2k4a map2k4a bmp2b bmp2b nrap nrap neb neb asb2a.1 asb2a.1 alpk2 alpk2 atg5 atg5 asb2a.2 asb2a.2 srfb srfb csrp3 csrp3 alpk3b alpk3b ENSDARP00000147138 ENSDARP00000147138 ENSDARP00000151202 ENSDARP00000151202 bmp2a bmp2a isl1 isl1 nkx2.7 nkx2.7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nkx2.5NK2 homeobox 5. (314 aa)
tcapTitin-cap (telethonin). (179 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
adprhl1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (350 aa)
lrrc10Leucine-rich repeat-containing 10. (269 aa)
srfaSerum response factor a. (539 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
opa1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). (966 aa)
map2k4bMitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily. (417 aa)
maml1Mastermind-like transcriptional coactivator 1. (1057 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
nrapNebulin-related-anchoring protein. (1861 aa)
nebNebulin. (6177 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
alpk2Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling. (1037 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
asb2a.2Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa)
srfbSerum response factor b. (260 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
alpk3bAlpha-kinase 3b. (1869 aa)
ENSDARP00000147138TGFb_propeptide domain-containing protein. (179 aa)
ENSDARP00000151202Peptidase_M48_N domain-containing protein. (272 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
nkx2.7NK2 transcription factor-related 7. (269 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.