STRINGSTRING
barx1 barx1 rad21a rad21a nkx2.7 nkx2.7 ednraa ednraa rad21l1 rad21l1 kctd15a kctd15a rad21b rad21b ednrab ednrab KCTD15 KCTD15 edn1 edn1 dlx2a dlx2a bmpr2b bmpr2b bmpr2a bmpr2a nkx3-1 nkx3-1 smad5 smad5 rarga rarga tbx1 tbx1 fgf8a fgf8a nkx2.5 nkx2.5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
barx1Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa)
rad21aDouble-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa)
nkx2.7NK2 transcription factor-related 7. (269 aa)
ednraaEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa)
rad21l1RAD21 cohesin complex component-like 1. (546 aa)
kctd15aBTB/POZ domain-containing protein kctd15-like. (257 aa)
rad21bRAD21 cohesin complex component b. (637 aa)
ednrabEndothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa)
KCTD15Potassium channel tetramerization domain containing 15. (156 aa)
edn1Endothelin 1. (188 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
nkx3-1NK3 homeobox 1. (214 aa)
smad5Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa)
rargaRetinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
nkx2.5NK2 homeobox 5. (314 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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