STRINGSTRING
strc1 strc1 mks1 mks1 sdc4 sdc4 trip11 trip11 cecr2 cecr2 cobl cobl pacsin1a pacsin1a tomt tomt pacsin1b pacsin1b grxcr1a grxcr1a clrn1 clrn1 ttc8 ttc8 pdzd7a pdzd7a tprn tprn pjvk pjvk grxcr1b grxcr1b whrnb whrnb cthrc1b cthrc1b ift88 ift88 cthrc1a cthrc1a foxj1b foxj1b ush1c ush1c whrna whrna cdh2 cdh2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
strc1Stereocilin 1. (2032 aa)
mks1MKS transition zone complex subunit 1. (559 aa)
sdc4Syndecan 4. (207 aa)
trip11Thyroid hormone receptor interactor 11. (1984 aa)
cecr2CECR2 histone acetyl-lysine reader. (1502 aa)
coblProtein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal develop [...] (1327 aa)
pacsin1aProtein kinase C and casein kinase substrate in neurons 1a. (438 aa)
tomtTransmembrane O-methyltransferase homolog; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. Component of the hair cell's mechanotransduction (MET) machinery. Involved in the assembly of the asymmetric tip-link MET complex. Required for transportation of TMC1 and TMC2 proteins into the mechanically sensitive stereocilia of the hair cells. The function in MET is independent of the enzymatic activity. (259 aa)
pacsin1bProtein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neur [...] (445 aa)
grxcr1aGlutaredoxin and cysteine-rich domain-containing 1 a. (295 aa)
clrn1Clrn1 protein. (232 aa)
ttc8Tetratricopeptide repeat domain 8. (268 aa)
pdzd7aPDZ domain-containing 7a. (954 aa)
tprnTaperin. (758 aa)
pjvkPejvakin. (361 aa)
grxcr1bGlutaredoxin and cysteine-rich domain-containing 1 b. (148 aa)
whrnbWhirlin b. (946 aa)
cthrc1bCollagen triple helix repeat-containing 1b. (233 aa)
ift88Intraflagellar transport 88 homolog. (824 aa)
cthrc1aCollagen triple helix repeat-containing 1a. (232 aa)
foxj1bForkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family. (442 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
whrnaWhirlin a. (939 aa)
cdh2Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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