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| | nxnl2 | Nucleoredoxin-like 2. (156 aa) |
| | rb1 | Retinoblastoma 1. (903 aa) |
| | oclna | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (491 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | ift57 | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. (407 aa) |
| | acp5a | Tartrate-resistant acid phosphatase type 5. (339 aa) |
| | hdac8 | Histone deacetylase 8; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (378 aa) |
| | gata1a | GATA-binding protein 1a. (418 aa) |
| | gdf5 | Growth differentiation factor 5. (474 aa) |
| | bsg | Basigin. (404 aa) |
| | sash3 | SAM and SH3 domain-containing 3. (386 aa) |
| | prlh | Prolactin-releasing hormone. (81 aa) |
| | ENSDARP00000137425 | Si:zfos-1011f11.2. (189 aa) |
| | lrrc45 | Leucine-rich repeat-containing 45. (674 aa) |
| | ENSDARP00000138435 | Si:ch211-286o17.1. (288 aa) |
| | csrp3 | Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa) |
| | vps54 | VPS54 subunit of GARP complex. (1031 aa) |
| | homer1b | Homer scaffold protein 1b. (398 aa) |
| | clrn1 | Clrn1 protein. (232 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | prkn | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (458 aa) |
| | acp5b | Tartrate-resistant acid phosphatase type 5. (327 aa) |
| | eys-2 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. (296 aa) |
| | klhl10b.2 | Kelch-like family member 10b, tandem duplicate 2. (606 aa) |
| | klhl10b.1 | Kelch-like family member 10b, tandem duplicate 1. (614 aa) |
| | tp53inp2-2 | Uncharacterized protein. (173 aa) |
| | dctn1a | Dynactin 1a. (1257 aa) |
| | cytl1 | Cytokine like 1. (145 aa) |
| | bbs12 | Bardet-Biedl syndrome 12. (763 aa) |
| | spata7 | Spermatogenesis-associated 7. (500 aa) |
| | mtf1 | Metal-regulatory transcription factor 1. (774 aa) |
| | Nox4 | NADPH oxidase 4. (246 aa) |
| | tjp1a | Tight junction protein 1a; Belongs to the MAGUK family. (1689 aa) |
| | klhl10a | Kelch-like family member 10a. (592 aa) |
| | crb1 | Crumbs cell polarity complex component 1. (1428 aa) |
| | trim32 | Tripartite motif-containing 32. (663 aa) |
| | adss1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa) |
| | nkiras1 | NF-kappa-B inhibitor-interacting Ras-like protein 1; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. (192 aa) |
| | uhrf1 | E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa) |
| | ncdn | Neurochondrin. (702 aa) |
| | srfb | Serum response factor b. (260 aa) |
| | immt | MICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (757 aa) |
| | iqcb1 | IQ motif-containing B1. (595 aa) |
| | iqcb1-2 | IQ motif-containing B1. (421 aa) |
| | fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | crb2b | Crumbs cell polarity complex component 2b. (1010 aa) |
| | ildr1a | Immunoglobulin-like domain-containing receptor 1a. (464 aa) |
| | lsr | Lipolysis-stimulated lipoprotein receptor. (599 aa) |
| | appa | Amyloid beta (A4) precursor protein a. (194 aa) |
| | si:dkey-7i4.24 | Si:dkey-7i4.24. (412 aa) |
| | X1WCE4_DANRE | Si:ch211-270g19.5. (52 aa) |
| | rp1l1a | Rp1-like 1a. (2394 aa) |
| | rp1l1b | Rp1-like 1b. (3919 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | tert | Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa) |
| | cep290 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa) |
| | bcl2b | BCL2 apoptosis regulator b. (209 aa) |
| | disc1 | DISC1 scaffold protein. (994 aa) |
| | cln8 | CLN8 transmembrane ER and ERGIC protein. (289 aa) |
| | mbpb | Myelin basic protein b. (133 aa) |
| | prlh2 | Prolactin-releasing hormone 2. (117 aa) |
| | CRACD | Capping protein inhibiting regulator of actin dynamics; Involved in epithelial cell integrity by acting on the maintenance of the actin cytoskeleton. Positively regulates the actin polymerization, by inhibiting the interaction of actin-capping proteins with actin. (1079 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | bbs10 | Bardet-Biedl syndrome 10. (151 aa) |
| | ttk | Dual specificity protein kinase Ttk; Phosphorylates proteins on serine, threonine, and tyrosine (By similarity). Involved in mitotic cell cycle checkpoint control. Required for fin and heart regeneration. Required to prevent chromosome segregation errors during meiosis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (983 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | rp2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa) |
| | whrnb | Whirlin b. (946 aa) |
| | tjp2a | Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1198 aa) |
| | hbl2 | Hexose-binding lectin 2. (253 aa) |
| | ercc6 | Excision repair cross-complementation group 6. (1389 aa) |
| | pth1a | Parathyroid hormone 1a. (102 aa) |
| | usp45 | Ubiquitin carboxyl-terminal hydrolase 45; May be involved in the maintenance of photoreceptor function. Belongs to the peptidase C19 family. (803 aa) |
| | LOC569566 | Fibroblast growth factor receptor 1b,-like. (509 aa) |
| | nxnl1 | Nucleoredoxin-like protein 1; May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods. Belongs to the nucleoredoxin family. (215 aa) |
| | nrf1 | Nuclear respiratory factor 1; Probable transcription factor that is required for normal development of the outer retina. (504 aa) |
| | tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |
| | cldn5b | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (220 aa) |
| | fxn | Frataxin. (200 aa) |
| | calb1 | Calbindin 1. (260 aa) |
| | lca5 | Lebercilin LCA5. (754 aa) |
| | E9QH19_DANRE | Si:dkey-261h17.1. (275 aa) |
| | pbld | Phenazine biosynthesis-like protein domain-containing. (286 aa) |
| | rp1 | RP1 axonemal microtubule-associated. (259 aa) |
| | pbld2 | Phenazine biosynthesis-like protein domain-containing 2. (286 aa) |
| | apoda.2 | Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa) |
| | tjp2b | Tight junction protein 2b (zona occludens 2). (1179 aa) |
| | prdm14 | PR domain-containing 14. (568 aa) |
| | nphp4 | Si:dkey-202c5.1 protein. (189 aa) |
| | hbl1 | Zmp:0000000729. (254 aa) |
| | strap | Serine/threonine kinase receptor-associated protein. (329 aa) |
| | F2R-5 | Si:dkey-163m14.6. (411 aa) |
| | F2R-3 | Si:dkey-163m14.4. (438 aa) |
| | emc3 | ER membrane protein complex subunit 3. (261 aa) |
| | lamp2 | Lysosomal-associated membrane protein 2. (355 aa) |
| | ush1c | Usher syndrome 1C (Autosomal recessive, severe). (548 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | bbs1 | Bardet-Biedl syndrome 1. (588 aa) |
| | inavaa | Innate immunity activator a. (596 aa) |
| | tmem175 | Endosomal/lysosomal potassium channel TMEM175; Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel; Belongs to the TMEM175 family. (520 aa) |
| | whrna | Whirlin a. (939 aa) |
| | csf1a | Colony-stimulating factor 1a (macrophage). (526 aa) |
| | tjp1b | Tight junction protein 1b; Belongs to the MAGUK family. (1689 aa) |
| | cluap1 | Clusterin-associated protein 1 homolog; Required for cilia biogenesis and maintenance in the kidney, the lateral line organ and eye. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Belongs to the CLUAP1 family. (427 aa) |
| | adgrf11 | Adhesion G protein-coupled receptor F11; Belongs to the G-protein coupled receptor 2 family. (691 aa) |
| | src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa) |
| | dctn1b | Dynactin 1b. (1258 aa) |
| | ezh1 | Enhancer of zeste 1 polycomb repressive complex 2 subunit. (147 aa) |
| | crfb16 | Cytokine receptor family member B16. (300 aa) |
| | csf1b | Colony-stimulating factor 1b (macrophage). (284 aa) |
| | mbl2 | Mannose-binding lectin 2. (251 aa) |
| | tnfsf11 | TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (1987 aa) |
| | inavab | Innate immunity activator b. (612 aa) |
| | nipblb | Nipped-B-like protein B; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). (2882 aa) |
| | ush2a | Usher syndrome 2A (autosomal recessive, mild). (5236 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | mks1 | MKS transition zone complex subunit 1. (559 aa) |
| | F2R | Si:dkey-163m14.2. (462 aa) |
| | gata1b | GATA-binding protein 1b. (361 aa) |
| | scgn | Secretagogin. (272 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | fgfr1b | Fibroblast growth factor receptor. (766 aa) |
| | vstm4b | V-set and transmembrane domain-containing 4b. (357 aa) |
| | nkiras2 | NF-kappa-B inhibitor-interacting Ras-like protein 2; Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. (192 aa) |
| | stk11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | ca7 | Carbonic anhydrase VII; Belongs to the alpha-carbonic anhydrase family. (263 aa) |
| | gdf11 | Growth differentiation factor 11. (390 aa) |
| | itgb6 | Integrin beta; Belongs to the integrin beta chain family. (782 aa) |
| | crocc2 | Ciliary rootlet coiled-coil, rootletin family member 2. (1959 aa) |
| | prrc1 | Protein PRRC1. (435 aa) |
| | sod1 | Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (154 aa) |
| | cldn5a | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (215 aa) |
| | ccn2a | Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa) |
| | p2rx7 | P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa) |
| | ift172 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | ctsh | Cathepsin H; Belongs to the peptidase C1 family. (330 aa) |
| | calb2a | Calbindin 2, like. (271 aa) |
| | fkbp14 | Peptidylprolyl isomerase. (211 aa) |
| | bag3 | BCL2-associated athanogene 3. (480 aa) |
| | vstm4a | V-set and transmembrane domain-containing 4a. (329 aa) |
| | calb2b | Calbindin 2b. (269 aa) |
| | ildr2 | Immunoglobulin-like domain-containing receptor 2. (590 aa) |
| | mfsd2aa | Sodium-dependent lysophosphatidylcholine symporter 1-A; Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega-3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and [...] (532 aa) |
| | dctn2 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). (405 aa) |
| | pafah1b1b | Lissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa) |
| | stil | SCL-interrupting locus protein homolog; Plays an essential role in early embryonic development. Plays an important role in the regulation of centriole duplication (By similarity). (1263 aa) |
| | hbl4 | Hexose-binding lectin 4. (245 aa) |
| | cav3 | Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa) |
| | lrrk1 | Leucine-rich repeat kinase 1. (1377 aa) |
| | poc1b | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa) |
| | tjp3 | Tight junction protein 3; Belongs to the MAGUK family. (1255 aa) |
| | mkks | McKusick-Kaufman syndrome. (563 aa) |
| | ezh2 | Histone-lysine N-methyltransferase EZH2; Polycomb group (PcG) protein. Catalytic subunit of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. May regulate the circadian clock via histone methylation at the promoter of the circadian genes; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily. (760 aa) |
