STRINGSTRING
atp6ap1b atp6ap1b rab23 rab23 nsd2 nsd2 ebp ebp jag1b jag1b sulf2a sulf2a optc optc chrna1 chrna1 meis1a meis1a lrrk1 lrrk1 sulf2b sulf2b serpinh1b serpinh1b tgfbr2b tgfbr2b ptpn11b ptpn11b rap1aa rap1aa fgf24 fgf24 lrrc17 lrrc17 sulf1 sulf1 bmpr2a bmpr2a atp6ap1a atp6ap1a cx43 cx43 pex7 pex7 atg9a atg9a dhrs3b dhrs3b itgb6 itgb6 dhrs3a dhrs3a chad chad pdgfc pdgfc ppib ppib bmp4 bmp4 srfa srfa ccn4a ccn4a ext2 ext2 lepr lepr ptpn11a ptpn11a zmpste24 zmpste24 tgfbr2a tgfbr2a glg1a glg1a phex phex frem1a frem1a kat2b kat2b abi1b abi1b sema4d sema4d tmem119b tmem119b tnfsf11 tnfsf11 src src sp5a sp5a ches1 ches1 anxa6 anxa6 M9MMA2_DANRE M9MMA2_DANRE ptprc ptprc mbtps2 mbtps2 fam20ca fam20ca nab2 nab2 ccn4b ccn4b serpinh1a serpinh1a trip11 trip11 sema4e sema4e cyp26b1 cyp26b1 fgf9 fgf9 slc38a10 slc38a10 epyc epyc gnptab gnptab fgf18a fgf18a bmpr2b bmpr2b fam20cb fam20cb rap1ab rap1ab tsku tsku vkorc1 vkorc1 rap1b rap1b mef2d mef2d gp9 gp9 TTC9 TTC9 ift80 ift80 abi1a abi1a gp1bb gp1bb atg9b atg9b sh2b3 sh2b3 mcph1 mcph1 foxn3 foxn3 ostn ostn ep300b ep300b trim45 trim45 glg1b glg1b edar edar phospho2 phospho2 wnt5b wnt5b srfb srfb ecm1b ecm1b fgf4 fgf4 wnt5a wnt5a ep300a ep300a frem1b frem1b bglapl bglapl bbx bbx bmp16 bmp16 msx1a msx1a ptpn6 ptpn6 csf1ra csf1ra ENSDARP00000148508 ENSDARP00000148508 ENSDARP00000151202 ENSDARP00000151202 sp5b sp5b kat2a kat2a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atp6ap1bATPase H+-transporting accessory protein 1b. (459 aa)
rab23RAB23, member RAS oncogene family. (237 aa)
nsd2Nuclear receptor-binding SET domain protein 2. (1461 aa)
ebpEBP cholestenol delta-isomerase. (232 aa)
jag1bProtein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa)
sulf2aExtracellular sulfatase. (873 aa)
optcOpticin. (322 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
meis1aMyeloid ecotropic viral integration site 4.1a. (380 aa)
lrrk1Leucine-rich repeat kinase 1. (1377 aa)
sulf2bExtracellular sulfatase. (885 aa)
serpinh1bSerpin peptidase inhibitor, clade H (heat shock protein 47), member 1b; Belongs to the serpin family. (405 aa)
tgfbr2bTGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
ptpn11bTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (592 aa)
rap1aaRAP1A, member of RAS oncogene family a. (185 aa)
fgf24Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
lrrc17Leucine-rich repeat-containing 17. (435 aa)
sulf1Sulfatase FP1c. (1099 aa)
bmpr2aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1003 aa)
atp6ap1aATPase H+-transporting accessory protein 1a. (466 aa)
cx43Gap junction alpha-1 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles (By similarity); Belongs to the connexin family. Alpha-type (group II) subfamily. (381 aa)
pex7Peroxisomal biogenesis factor 7. (314 aa)
atg9aAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (846 aa)
dhrs3bDehydrogenase/reductase (SDR family) member 3b; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
itgb6Integrin beta; Belongs to the integrin beta chain family. (782 aa)
dhrs3aDehydrogenase/reductase (SDR family) member 3a. (302 aa)
chadChondroadherin. (363 aa)
pdgfcPlatelet-derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (343 aa)
ppibPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (208 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
srfaSerum response factor a. (539 aa)
ccn4aCellular communication network factor 4a. (360 aa)
ext2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (719 aa)
leprLeptin receptor. (1065 aa)
ptpn11aTyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
tgfbr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
glg1aGolgi glycoprotein 1a. (1151 aa)
phexPhosphate-regulating endopeptidase homolog, X-linked. (745 aa)
frem1aFras1-related extracellular matrix 1a. (2167 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
abi1bAbl-interactor 1b. (502 aa)
sema4dUncharacterized protein; Belongs to the semaphorin family. (856 aa)
tmem119bTransmembrane protein 119b. (294 aa)
tnfsf11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (251 aa)
srcProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa)
sp5aSp5 transcription factor a. (368 aa)
ches1Checkpoint suppressor 1. (443 aa)
anxa6Annexin. (577 aa)
M9MMA2_DANRESi:ch211-129c21.1; Belongs to the semaphorin family. (775 aa)
ptprcProtein tyrosine phosphatase receptor type C. (1130 aa)
mbtps2Membrane-bound transcription factor peptidase, site 2. (494 aa)
fam20caFAM20C golgi-associated secretory pathway kinase a. (545 aa)
nab2NGFI-A-binding protein 2 (EGR1 binding protein 2). (491 aa)
ccn4bCellular communication network factor 4b. (356 aa)
serpinh1aSerpin peptidase inhibitor, clade H (heat shock protein 47), member 1a; Belongs to the serpin family. (403 aa)
trip11Thyroid hormone receptor interactor 11. (1984 aa)
sema4eSemaphorin-4E. (766 aa)
cyp26b1Cytochrome P450 26B1; Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Appears to be involved in the inactivation of all-trans-retinoic acid (RA). Plays a role in skeletal development; Belongs to the cytochrome P450 family. (511 aa)
fgf9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (142 aa)
slc38a10Solute carrier family 38 member 10. (1132 aa)
epycEpiphycan. (712 aa)
gnptabN-acetylglucosamine-1-phosphotransferase subunits alpha/beta; Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment. (1219 aa)
fgf18aFibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (208 aa)
bmpr2bReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1071 aa)
fam20cbFAM20C golgi-associated secretory pathway kinase b. (557 aa)
rap1abRAP1A, member of RAS oncogene family b. (185 aa)
tskuTsukushin; Dorsalizing factor. Functions as an inhibitor of bone morphogenetic proteins (BMP) during gastrulation. (347 aa)
vkorc1Vitamin K epoxide reductase complex, subunit 1. (171 aa)
rap1bRas-related protein Rap-1b; Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family. (184 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
gp9Glycoprotein IX (platelet). (267 aa)
TTC9Si:ch211-259k16.3. (176 aa)
ift80Intraflagellar transport 80 homolog (Chlamydomonas). (777 aa)
abi1aAbl-interactor 1a. (483 aa)
gp1bbGlycoprotein Ib platelet subunit beta. (207 aa)
atg9bAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (806 aa)
sh2b3SH2B adaptor protein 3. (596 aa)
mcph1Microcephalin 1. (463 aa)
foxn3Forkhead box N3. (441 aa)
ostnOsteocrin. (134 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
trim45Tripartite motif-containing 45. (546 aa)
glg1bGolgi glycoprotein 1b. (525 aa)
edarEctodysplasin A receptor. (460 aa)
phospho2Phosphatase, orphan 2. (241 aa)
wnt5bProtein Wnt-5b; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. Required during embryogenesis for extension of the primary anterior-posterior axis. (363 aa)
srfbSerum response factor b. (260 aa)
ecm1bExtracellular matrix protein 1b. (499 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (191 aa)
wnt5aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
frem1bFras1-related extracellular matrix 1b. (2166 aa)
bglaplOsteocalcin; Binds strongly to apatite and calcium. (182 aa)
bbxBBX high mobility group box domain-containing. (899 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
msx1aMuscle segment homeobox 1a. (233 aa)
ptpn6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (590 aa)
csf1raMacrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa)
ENSDARP00000148508ecTbetaR2 domain-containing protein. (382 aa)
ENSDARP00000151202Peptidase_M48_N domain-containing protein. (272 aa)
sp5bUncharacterized protein. (291 aa)
kat2aHistone acetyltransferase KAT2A; Protein lysine acyltransferase that can act as a acetyltransferase, glutaryltransferase or succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for [...] (819 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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