STRINGSTRING
tnni1a tnni1a hey2 hey2 csrp1a csrp1a ednraa ednraa gdf5 gdf5 p2rx2 p2rx2 nkx2.7 nkx2.7 myl1 myl1 btg2 btg2 myod1 myod1 myog myog zgc:172270 zgc:172270 gpcpd1 gpcpd1 arid2 arid2 klhl41b klhl41b klf5a klf5a isl1 isl1 klhl40b klhl40b smo smo bmp2a bmp2a fgfr1a fgfr1a dipk2aa dipk2aa nkx2.5 nkx2.5 rbfox1l rbfox1l fgf8a fgf8a zfand5a zfand5a ankrd33ab ankrd33ab rb1 rb1 chrna1 chrna1 zfand5b zfand5b mpp5b mpp5b hand2 hand2 mylpfb mylpfb unc45b unc45b lamc1 lamc1 sav1 sav1 tnnc1a tnnc1a tbx3a tbx3a tbx20 tbx20 tcap tcap atf3 atf3 tbx2a tbx2a six1b six1b zgc:77486 zgc:77486 myo9ab myo9ab dpf3 dpf3 tbx5a tbx5a cav3 cav3 tsc1a tsc1a nprl3 nprl3 myo9aa myo9aa myl7 myl7 myf6 myf6 tbx1 tbx1 cyp26a1 cyp26a1 grem1a grem1a wnt2bb wnt2bb csrp1b csrp1b fermt2 fermt2 myoz2a myoz2a FOXN2 FOXN2 ifrd2 ifrd2 tcf21 tcf21 tnnc1b tnnc1b klhl40a klhl40a six1a six1a zfpm2a zfpm2a meox2a meox2a myoz1a myoz1a tgfb1a tgfb1a adprhl1 adprhl1 vgll2a vgll2a disp1 disp1 foxn2b foxn2b lrrc10 lrrc10 spg11 spg11 aplnra aplnra bmp4 bmp4 fgfr1b fgfr1b mylpfa mylpfa poglut1 poglut1 gdf6a gdf6a srfa srfa smyd2a smyd2a cdk5 cdk5 ankrd33ba ankrd33ba bves bves popdc3 popdc3 zmpste24 zmpste24 mtmr12 mtmr12 myo9b myo9b ripor2 ripor2 meox2b meox2b lmod3 lmod3 mef2ca mef2ca ifrd1 ifrd1 klhl41a klhl41a mstnb mstnb gja5b gja5b popdc2 popdc2 wnt2ba wnt2ba opa1 opa1 zgc:158296 zgc:158296 lrrc39 lrrc39 tgfb5 tgfb5 smad4a smad4a ankrd1a ankrd1a gb:cr929477 gb:cr929477 map2k4b map2k4b maml1 maml1 mylk3 mylk3 mtor mtor map2k4a map2k4a hlfa hlfa LOC100332300 LOC100332300 bmp2b bmp2b nrap nrap aplnrb aplnrb myf5 myf5 tbx3b tbx3b sema3c sema3c alpk3a alpk3a vrk3 vrk3 apoda.2 apoda.2 svilb svilb phox2ba phox2ba mef2d mef2d csrp2 csrp2 hlx1 hlx1 nr2f1a nr2f1a mef2aa mef2aa acadm acadm emd emd lamc3 lamc3 neb neb ankrd33aa ankrd33aa LOC569566 LOC569566 asb2a.1 asb2a.1 dipk2ab dipk2ab cemip2 cemip2 ripor3 ripor3 sgcg sgcg tsc1b tsc1b selenon selenon nf1b nf1b Q1L8R8_DANRE Q1L8R8_DANRE taz taz kdm6bb kdm6bb gja5a gja5a cby1 cby1 tgfb1b tgfb1b ankrd33bb ankrd33bb klf5b klf5b alpk2 alpk2 mpp5a mpp5a myoz2b myoz2b elnb elnb tgfb2 tgfb2 atg5 atg5 ednrab ednrab tnni1b tnni1b kel kel E7FFZ5_DANRE E7FFZ5_DANRE shha shha klf5l klf5l arpp21 arpp21 asb2a.2 asb2a.2 hlfb hlfb rbm24b rbm24b grem2a grem2a X1WCE4_DANRE X1WCE4_DANRE svilc svilc nf1a nf1a ep300b ep300b phox2bb phox2bb smyd1b smyd1b LOC108190739 LOC108190739 nupr1a nupr1a tefb tefb sgcd sgcd dner dner stac3 stac3 plekha7a plekha7a srfb srfb foxo1a foxo1a sirt6 sirt6 vwa5b2 vwa5b2 rbm24a rbm24a bin3 bin3 adss1 adss1 r3hdm2 r3hdm2 mef2cb mef2cb csrp3 csrp3 zfpm2b zfpm2b homer1b homer1b r3hdm1 r3hdm1 irx3a irx3a ep300a ep300a qkia qkia cav1 cav1 ENSDARP00000142127 ENSDARP00000142127 mef2ab mef2ab alpk3b alpk3b kdm6ba kdm6ba tnni4b.1 tnni4b.1 SGCZ SGCZ bmp16 bmp16 tnni4b.2 tnni4b.2 tnni4a tnni4a ENSDARP00000147138 ENSDARP00000147138 hoxc10a hoxc10a qkib qkib svila svila msc msc ENSDARP00000151202 ENSDARP00000151202 svild svild bcl9 bcl9 ENSDARP00000153449 ENSDARP00000153449 ENSDARP00000153909 ENSDARP00000153909 Nox4 Nox4 nphs1 nphs1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnni1aTroponin I type 1a (skeletal, slow). (181 aa)
hey2Hairy/enhancer-of-split related with YRPW motif protein 2; Transcriptional repressor (By similarity). Downstream effector of Notch signaling which regulates cell fate choice in angioblasts. Represses the venous cell fate, thereby promoting the arterial cell fate and aorta formation; Belongs to the HEY family. (324 aa)
csrp1aCysteine and glycine-rich protein 1a. (192 aa)
ednraaEndothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa)
gdf5Growth differentiation factor 5. (474 aa)
p2rx2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (400 aa)
nkx2.7NK2 transcription factor-related 7. (269 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
btg2Anti-proliferative cofactor. (165 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
zgc:172270Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (185 aa)
gpcpd1Glycerophosphocholine phosphodiesterase 1. (666 aa)
arid2AT-rich interactive domain 2 (ARID, RFX-like). (1572 aa)
klhl41bKelch-like protein 41b; Involved in skeletal muscle development and maintenance. (605 aa)
klf5aProgesterone immunomodulatory-binding factor 1. (429 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
klhl40bKelch-like protein 40b; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (618 aa)
smoSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa)
bmp2aBone morphogenetic protein 2a. (386 aa)
fgfr1aFibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa)
dipk2aaDivergent protein kinase domain 2Aa. (432 aa)
nkx2.5NK2 homeobox 5. (314 aa)
rbfox1lRNA binding protein fox-1 homolog 1-like; RNA-binding protein that regulates alternative splicing events by binding to 5'-GCAUG-3' elements. Regulates alternative splicing of tissue-specific exons. (382 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
zfand5aZinc finger, AN1-type domain 5a. (213 aa)
ankrd33abAnkyrin repeat domain 33Ab. (462 aa)
rb1Retinoblastoma 1. (903 aa)
chrna1Acetylcholine receptor subunit alpha; After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. (456 aa)
zfand5bZinc finger, AN1-type domain 5b. (212 aa)
mpp5bMembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa)
hand2Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa)
mylpfbMyosin light chain, phosphorylatable, fast skeletal muscle b. (170 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
lamc1Laminin subunit gamma-1; Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (1593 aa)
sav1Salvador family WW domain-containing protein 1. (397 aa)
tnnc1aTroponin C type 1a (slow). (161 aa)
tbx3aT-box transcription factor 3a. (689 aa)
tbx20T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
tcapTitin-cap (telethonin). (179 aa)
atf3Activating transcription factor 3. (202 aa)
tbx2aT-box transcription factor 2a. (686 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
zgc:77486Zgc:77486. (238 aa)
myo9abUnconventional myosin-IXAb; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance. (2286 aa)
dpf3Zinc finger protein DPF3; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and may play a role in neural development (By similarity). Plays an essential role in heart and skeletal [...] (391 aa)
tbx5aT-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
tsc1aTSC complex subunit 1a. (1128 aa)
nprl3NPR3-like, GATOR1 complex subunit. (581 aa)
myo9aaUnconventional myosin-IXAa; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Regulates Rho by stimulating it's GTPase activity in neurons (By similarity). Required for the regulation of neurite branching and motor neuron axon guidance. (2522 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
tbx1T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
cyp26a1Cytochrome P450 26A1; A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomer [...] (492 aa)
grem1aGremlin. (177 aa)
wnt2bbProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (396 aa)
csrp1bCysteine and glycine-rich protein 1b. (192 aa)
fermt2Fermitin family homolog 2; Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and ce [...] (684 aa)
myoz2aMyozenin 2a. (264 aa)
FOXN2Forkhead box N2. (300 aa)
ifrd2Interferon-related developmental regulator 2. (435 aa)
tcf21Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa)
tnnc1bTroponin C type 1b (slow). (161 aa)
klhl40aKelch-like protein 40a; ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development ; Belongs to the KLHL40 family. (612 aa)
six1aHomeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. (283 aa)
zfpm2aZinc finger protein, FOG family member 2a. (1142 aa)
meox2aMesenchyme homeobox 2a. (302 aa)
myoz1aZgc:77785 protein. (319 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
adprhl1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (350 aa)
vgll2aVestigial-like family member 2a. (296 aa)
disp1Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (By similarity); Belongs to the dispatched family. (1464 aa)
foxn2bForkhead box N2b. (388 aa)
lrrc10Leucine-rich repeat-containing 10. (269 aa)
spg11SPG11 vesicle-trafficking-associated, spatacsin. (1612 aa)
aplnraApelin receptor A; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (362 aa)
bmp4Bone morphogenetic protein 4. (400 aa)
fgfr1bFibroblast growth factor receptor. (766 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
poglut1Protein O-glucosyltransferase 1. (389 aa)
gdf6aGrowth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa)
srfaSerum response factor a. (539 aa)
smyd2aN-lysine methyltransferase SMYD2-A; Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'; Belongs to the class V-like SAM-binding methyltransferase superfamily. (435 aa)
cdk5Cyclin-dependent protein kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ankrd33baAnkyrin repeat domain 33ba. (510 aa)
bvesBlood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa)
popdc3Popeye domain-containing 3. (294 aa)
zmpste24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (468 aa)
mtmr12Myotubularin-related protein 12; Acts as an adapter for the myotubularin phosphatase mtm1 to regulate mtm1 protein stability and possibly its intracellular location. By stabilizing mtm1 protein levels, required for skeletal muscle maintenance but not for myogenesis. In skeletal muscle cells, does not regulate mtm1 subcellular localization. (736 aa)
myo9bMyosin IXb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1974 aa)
ripor2Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (By similarity). Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis an [...] (1083 aa)
meox2bMesenchyme homeobox 2b. (289 aa)
lmod3Leiomodin-3; Essential for the organization of sarcomeric thin filaments in skeletal muscle; Belongs to the tropomodulin family. (670 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
ifrd1Interferon-related developmental regulator 1. (427 aa)
klhl41aKelch-like protein 41a; Involved in skeletal muscle development and differentiation. (599 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
gja5bGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (370 aa)
popdc2Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa)
wnt2baProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (387 aa)
opa1Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). (966 aa)
zgc:158296Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (171 aa)
lrrc39Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
smad4aMothers against decapentaplegic homolog. (547 aa)
ankrd1aAnkyrin repeat domain 1a (cardiac muscle). (317 aa)
gb:cr929477SMAD family member 4. (332 aa)
map2k4bMitogen-activated protein kinase kinase 4B; Belongs to the protein kinase superfamily. (417 aa)
maml1Mastermind-like transcriptional coactivator 1. (1057 aa)
mylk3Myosin light chain kinase 3; Kinase that phosphorylates MYL2 in vitro (By similarity). Increases cardiomyocyte contractility (By similarity). Required for sarcomere formation in the developing heart. (716 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2563 aa)
map2k4aMitogen-activated protein kinase kinase 4A; Belongs to the protein kinase superfamily. (404 aa)
hlfaHLF transcription factor, PAR bZIP family member a. (294 aa)
LOC100332300Gremlin 1a, DAN family BMP antagonist. (177 aa)
bmp2bBone morphogenetic protein 2b. (411 aa)
nrapNebulin-related-anchoring protein. (1861 aa)
aplnrbApelin receptor B; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Positively regulates angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during [...] (359 aa)
myf5Myogenic factor. (237 aa)
tbx3bT-box transcription factor 3b. (594 aa)
sema3cSema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C. (713 aa)
alpk3aAlpha-kinase 3a. (636 aa)
vrk3VRK serine/threonine kinase 3. (512 aa)
apoda.2Apolipoprotein Da, duplicate 2; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
svilbSupervillin b. (179 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
mef2dMyocyte enhancer factor 2d. (529 aa)
csrp2Cysteine and glycine-rich protein 2. (193 aa)
hlx1H2.0-like homeo box 1 (Drosophila). (356 aa)
nr2f1aNuclear receptor subfamily 2 group F member 1-A; Putative transcription factor that is required in photoreceptor cells precursors during eye development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (411 aa)
mef2aaMyocyte enhancer factor 2aa. (458 aa)
acadmAcyl-CoA dehydrogenase medium chain. (426 aa)
emdEmerin (Emery-Dreifuss muscular dystrophy). (182 aa)
lamc3Laminin, gamma 3. (1643 aa)
nebNebulin. (6177 aa)
ankrd33aaAnkyrin repeat domain 33Aa. (428 aa)
LOC569566Fibroblast growth factor receptor 1b,-like. (509 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
dipk2abDivergent protein kinase domain 2Ab. (429 aa)
cemip2Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan. Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling. Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis. Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion. Involved in the restriction of endocardia [...] (1378 aa)
ripor3RIPOR family member 3; Belongs to the RIPOR family. (997 aa)
sgcgSarcoglycan, gamma. (292 aa)
tsc1bTSC complex subunit 1b. (1228 aa)
selenonSelenoprotein N; Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage (By similarity). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Plays an important role [...] (557 aa)
nf1bNeurofibromin 1b. (2759 aa)
Q1L8R8_DANREMothers against decapentaplegic homolog. (571 aa)
tazTafazzin family protein; Belongs to the taffazin family. (262 aa)
kdm6bbLysine (K)-specific demethylase 6B, b. (1719 aa)
gja5aGap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (400 aa)
cby1Chibby homolog 1 (Drosophila). (125 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
ankrd33bbAnkyrin repeat domain 33Bb. (448 aa)
klf5bKruppel-like factor 5b. (344 aa)
alpk2Alpha-protein kinase 2; Protein kinase that recognizes phosphorylation sites in which the surrounding peptides have an alpha-helical conformation (By similarity). Regulates cardiac development and cardiomyocyte differentiation by negatively regulating Wnt/beta-catenin signaling. (1037 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
myoz2bMyozenin 2b. (226 aa)
elnbElastin b. (2041 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
atg5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
ednrabEndothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa)
tnni1bTroponin I type 1b (skeletal, slow). (182 aa)
kelKell metallo-endopeptidase (Kell blood group). (759 aa)
E7FFZ5_DANREMothers against decapentaplegic homolog. (568 aa)
shhaSonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa)
klf5lKruppel-like factor 5 like. (401 aa)
arpp21cAMP-regulated phosphoprotein, 21. (688 aa)
asb2a.2Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa)
hlfbHLF transcription factor, PAR bZIP family member b. (299 aa)
rbm24bRNA-binding motif protein 24b. (245 aa)
grem2aGremlin 2, DAN family BMP antagonist a. (195 aa)
X1WCE4_DANRESi:ch211-270g19.5. (52 aa)
svilcSupervillin c. (1531 aa)
nf1aNeurofibromin 1a. (2759 aa)
ep300bE1A-binding protein p300 b. (2615 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
smyd1bSET and MYND domain-containing 1b. (486 aa)
LOC108190739Myozenin-2-like. (122 aa)
nupr1aNuclear protein 1a. (76 aa)
tefbTEF transcription factor, PAR bZIP family member b. (309 aa)
sgcdSarcoglycan, delta (dystrophin-associated glycoprotein). (292 aa)
dnerDelta/notch-like EGF repeat-containing. (744 aa)
stac3SH3 and cysteine-rich domain-containing protein 3; Required for normal excitation-contraction coupling in skeletal muscle and for normal muscle contraction in response to membrane depolarization. Required for normal Ca(2+) release from the sarcplasmic reticulum, which ultimately leads to muscle contraction. Probably functions via its effects on muscle calcium channels. Increases CACNA1S channel activity, in addition to its role in enhancing the expression of CACNA1S at the cell membrane. Has a redundant role in promoting the expression of the calcium channel CACNA1S at the cell membran [...] (334 aa)
plekha7aPleckstrin homology domain-containing family A member 7; Required for zonula adherens biogenesis and maintenance. (1264 aa)
srfbSerum response factor b. (260 aa)
foxo1aForkhead box protein O1-A; Transcriptional regulator of cell cycle arrest required for cellular stress responses (By similarity). May be involved in regulating cellular homeostasis in the eye. (652 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
vwa5b2Von Willebrand factor A domain-containing 5B2. (1132 aa)
rbm24aRNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa)
bin3Bridging integrator 3. (253 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (456 aa)
r3hdm2R3H domain-containing 2. (923 aa)
mef2cbMyocyte enhancer factor 2cb. (483 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
zfpm2bZinc finger protein, FOG family member 2b. (1093 aa)
homer1bHomer scaffold protein 1b. (398 aa)
r3hdm1R3H domain-containing 1. (815 aa)
irx3aIroquois 3 homeobox protein. (454 aa)
ep300aE1A-binding protein p300 a. (2679 aa)
qkiaProtein quaking-A; RNA-binding protein that plays a central role in myelinization. Binds to the 5'-NACUAAY-N(1,20)-UAAY-3' RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of some pre-mRNA. Acts as a translational repressor (By similarity). (383 aa)
cav1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (181 aa)
ENSDARP00000142127Si:ch211-42c5.5. (230 aa)
mef2abMyocyte enhancer factor 2ab. (305 aa)
alpk3bAlpha-kinase 3b. (1869 aa)
kdm6baLysine (K)-specific demethylase 6B, a. (1996 aa)
tnni4b.1Troponin I4b, tandem duplicate 1. (181 aa)
SGCZSarcoglycan zeta. (300 aa)
bmp16Bone morphogenetic protein 16. (416 aa)
tnni4b.2Troponin I4b, tandem duplicate 2. (218 aa)
tnni4aTroponin I4a. (183 aa)
ENSDARP00000147138TGFb_propeptide domain-containing protein. (179 aa)
hoxc10aHomeobox C10a. (337 aa)
qkibProtein quaking-B. (347 aa)
svilaSupervillin a. (1763 aa)
mscMusculin (activated B-cell factor-1). (160 aa)
ENSDARP00000151202Peptidase_M48_N domain-containing protein. (272 aa)
svildSupervillin d. (1468 aa)
bcl9BCL9 transcription coactivator. (1573 aa)
ENSDARP00000153449HP domain-containing protein. (82 aa)
ENSDARP00000153909BZIP domain-containing protein. (91 aa)
Nox4NADPH oxidase 4. (246 aa)
nphs1NPHS1 adhesion molecule, nephrin. (1287 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]