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| | dzip1 | Zinc finger protein Dzip1; Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Required for establishment of left-right asymmetry during embryogenesis. Has a role in primary cilium formation. (897 aa) |
| | ENSDARP00000157477 | Nuclear receptor domain-containing protein. (173 aa) |
| | ENSDARP00000155148 | Uncharacterized protein. (70 aa) |
| | ENSDARP00000154609 | Uncharacterized protein. (112 aa) |
| | ENSDARP00000153433 | annotation not available (144 aa) |
| | ENSDARP00000153406 | DUF3384 domain-containing protein. (162 aa) |
| | ENSDARP00000153246 | Ig-like domain-containing protein. (160 aa) |
| | alcama | CD166 antigen homolog A; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothel [...] (564 aa) |
| | msc | Musculin (activated B-cell factor-1). (160 aa) |
| | mthfd1a | C-1-tetrahydrofolate synthase, cytoplasmic isoform X2. (919 aa) |
| | snx10a | Sorting nexin-10A; Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. (229 aa) |
| | spint1a | Serine peptidase inhibitor, Kunitz type 1 a. (523 aa) |
| | sfrp2l | Secreted frizzled-related protein 2-like. (333 aa) |
| | ENSDARP00000148508 | ecTbetaR2 domain-containing protein. (382 aa) |
| | LOC103910016 | Uncharacterized protein. (146 aa) |
| | ENSDARP00000147138 | TGFb_propeptide domain-containing protein. (179 aa) |
| | ENSDARP00000145624 | Uncharacterized protein. (68 aa) |
| | phactr4a-2 | Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa) |
| | bmp16 | Bone morphogenetic protein 16. (416 aa) |
| | nkd1 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa) |
| | klhl3 | Kelch-like protein 3; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. (637 aa) |
| | dvl3 | Dishevelled segment polarity protein 3b. (706 aa) |
| | tbxta | T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa) |
| | hs2st1a | Heparan sulfate 2-O-sulfotransferase 1a. (354 aa) |
| | LOC100333521 | Pept_C1 domain-containing protein; Belongs to the peptidase C1 family. (303 aa) |
| | pdlim7 | PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa) |
| | irx3a | Iroquois 3 homeobox protein. (454 aa) |
| | ccdc40 | Coiled-coil domain-containing protein 40; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm (IDA) complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Probably acts together with ccdc39 to form a molecular ruler that determines the 96 nanometer (nm) repeat length and arrangements of components in cilia and flagella. Belongs to the CCDC40 family. (941 aa) |
| | krit1 | Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa) |
| | lrrc1 | Leucine-rich repeat-containing 1. (438 aa) |
| | irx1a | Iroquois homeobox protein 1, a. (426 aa) |
| | rangrf | Ran guanine nucleotide release factor; May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP. Plays a role in the regulation of the levels of GTP-bound RAN in the nucleus (By similarity). Required for normal expression of the ion channel hcn4 and for normal expression of the cardiac transcription factors nkx2.5, gata4 and hand2 during embryonic development. Required for normal embryonic heart development and normal heart rate. (183 aa) |
| | phactr4a | Phosphatase and actin regulator 4A. (1011 aa) |
| | spry1 | Sprouty homolog 1, antagonist of FGF-signaling (Drosophila). (292 aa) |
| | rbm24a | RNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa) |
| | prkacaa | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa) |
| | lrp6 | Low density lipoprotein receptor-related protein 6. (935 aa) |
| | vdra | Vitamin D3 receptor A. (234 aa) |
| | srfb | Serum response factor b. (260 aa) |
| | foxj1a | Forkhead box protein J1-A; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Its activity is sufficient for ectopic development of cilia that resemble motile cilia. (458 aa) |
| | vegfaa | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. (188 aa) |
| | sufu | Suppressor of fused homolog. (485 aa) |
| | wtip | Wilms tumor protein 1-interacting protein homolog; May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity); Belongs to the zyxin/ajuba family. (648 aa) |
| | nipbla | Nipped-B-like protein A; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). Belongs to the SCC2/Nipped-B family. (2382 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | tsc2 | TSC complex subunit 2. (1674 aa) |
| | gpr22b | G protein-coupled receptor 22b. (440 aa) |
| | setdb2 | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis. During early development, required to specify the left-right [...] (546 aa) |
| | luzp1 | Leucine zipper protein 1. (1034 aa) |
| | mical2a | Microtubule-associated monooxygenase, calponin and LIM domain-containing 2a. (834 aa) |
| | grem2a | Gremlin 2, DAN family BMP antagonist a. (195 aa) |
| | rbm24b | RNA-binding motif protein 24b. (245 aa) |
| | pkd1b | Polycystic kidney disease 1b. (3827 aa) |
| | asb2a.2 | Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa) |
| | vdrb | Vitamin D3 receptor B; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. (422 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | cep290 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa) |
| | bcl2b | BCL2 apoptosis regulator b. (209 aa) |
| | abl1 | Tyrosine-protein kinase. (1081 aa) |
| | hace1 | E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. (905 aa) |
| | gdnfa | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake (By similarity). Essential for the development of the enteric nervous system, but appears dispensable for the development of the kidney and primary motor neuron; Belongs to the TGF-beta family. GDNF subfamily. (235 aa) |
| | E7FFZ5_DANRE | Mothers against decapentaplegic homolog. (568 aa) |
| | ednrab | Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | ahi1 | Abelson helper integration site 1. (1193 aa) |
| | F8W5A4_DANRE | Si:ch73-236e11.2. (120 aa) |
| | sostdc1b | Sclerostin domain-containing 1b. (204 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | fsta | Follistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa) |
| | rad21b | RAD21 cohesin complex component b. (637 aa) |
| | hoxb1b | Homeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa) |
| | tgfb1b | Transforming growth factor beta; Belongs to the TGF-beta family. (379 aa) |
| | mthfr | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (656 aa) |
| | tmed2 | Transmembrane p24-trafficking protein 2. (208 aa) |
| | cep162 | Centrosomal protein of 162 kDa; Required to promote assembly of the transition zone in primary cilia. Acts by specifically recognizing and binding the axonemal microtubule. (1367 aa) |
| | wt1b | WT1 transcription factor b. (412 aa) |
| | bcl2a | B-cell leukemia/lymphoma 2. (228 aa) |
| | mdn1 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5523 aa) |
| | dvl1a | Dishevelled segment polarity protein 1a. (569 aa) |
| | rp2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa) |
| | Q1L8R8_DANRE | Mothers against decapentaplegic homolog. (571 aa) |
| | mical2b | Protein-methionine sulfoxide oxidase mical2b; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrt [...] (1679 aa) |
| | hnf1ba | Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa) |
| | tsc1b | TSC complex subunit 1b. (1228 aa) |
| | cemip2 | Cell surface hyaluronidase; Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate- size hyaluronan. Acts as a regulator of angiogenesis in embryos by mediating degradation of extracellular hyaluronan, thereby promoting VEGF signaling. Acts as a regulator of heart development during myocardial and endocardial morphogenesis: involved in the looping stage of heart morphogenesis. Stimulates migration of endocardial cells and increases both myocardial and endocardial fusion. Involved in the restriction of endocardia [...] (1378 aa) |
| | gdf7 | Growth differentiation factor 7. (396 aa) |
| | cthrc1b | Collagen triple helix repeat-containing 1b. (233 aa) |
| | prkx | Protein kinase X-linked; Belongs to the protein kinase superfamily. (357 aa) |
| | asb2a.1 | Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa) |
| | kdm6a | Lysine (K)-specific demethylase 6A. (1390 aa) |
| | nkx3-1 | NK3 homeobox 1. (214 aa) |
| | dnaaf1 | Dynein assembly factor 1, axonemal; Cilium-specific protein required for the stability of the ciliary architecture. Involved in regulation of microtubule-based cilia and actin-based brush border microvilli (Probable). (562 aa) |
| | ppp3r1a | Protein phosphatase 3, regulatory subunit B, alpha a. (170 aa) |
| | greb1 | Growth-regulating estrogen receptor-binding 1. (1840 aa) |
| | cthrc1a | Collagen triple helix repeat-containing 1a. (232 aa) |
| | setd2 | SET domain-containing 2, histone lysine methyltransferase. (2737 aa) |
| | pax5 | Paired box 5. (396 aa) |
| | lef1 | Lymphocyte enhancer binding factor 1 Lef1. (365 aa) |
| | tbx16l | T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa) |
| | lrrc6 | Protein tilB homolog; Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules. Belongs to the tilB family. (440 aa) |
| | commd5 | COMM domain-containing 5. (212 aa) |
| | B0UY55_DANRE | Si:dkey-91i10.2. (1093 aa) |
| | nrarpa | Notch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (112 aa) |
| | tbx3b | T-box transcription factor 3b. (594 aa) |
| | lrp5 | Low density lipoprotein receptor-related protein 5. (1615 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | gpr22a | G-protein coupled receptor 22; Orphan G-protein coupled receptor that regulates cilia length and structure in the Kupffer's vesicle leading to the left-right asymmetry development by establishing a directional fluid flow. (460 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | deaf1 | DEAF1 transcription factor. (528 aa) |
| | foxj1b | Forkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family. (442 aa) |
| | LOC100332300 | Gremlin 1a, DAN family BMP antagonist. (177 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | wnt6b | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | nfatc4 | Nuclear factor of-activated T cells 4. (865 aa) |
| | tctn1 | Tectonic family member 1. (534 aa) |
| | fuz | Fuzzy planar cell polarity protein. (420 aa) |
| | csf1a | Colony-stimulating factor 1a (macrophage). (526 aa) |
| | nphp3 | Nephrocystin-3; Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. (1303 aa) |
| | cecr2 | CECR2 histone acetyl-lysine reader. (1502 aa) |
| | rspo2 | R-spondin 2_variant1. (248 aa) |
| | spns2 | Protein spinster homolog 2; Transports sphingosine 1-phosphate (S1P), a secreted lipid mediator that plays critical roles in regulating heart development. Mediates the export of S1P from cells in the extraembryonic yolk syncytial layer (YSL), thereby regulating myocardial precursor migration ; Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family. (105 aa) |
| | dlx5a | Homeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa) |
| | gb:cr929477 | SMAD family member 4. (332 aa) |
| | timeless | Timeless circadian clock. (1278 aa) |
| | lzts2b | Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (608 aa) |
| | dlg5b.1 | Discs, large homolog 5b (Drosophila), tandem duplicate 1; Belongs to the MAGUK family. (1888 aa) |
| | smad4a | Mothers against decapentaplegic homolog. (547 aa) |
| | dlx4b | Homeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa) |
| | dlg5a | Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa) |
| | stm | Protein starmaker; Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths. (613 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | dvl1b | Dishevelled segment polarity protein 1b. (716 aa) |
| | dlx6a | Homeobox protein Dlx6a. (247 aa) |
| | sfrp2 | Secreted frizzled-related protein 2. (294 aa) |
| | podxl | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (445 aa) |
| | popdc2 | Popeye domain-containing 2; Important for striated muscle differentiation and cardiac morphogenesis. Is also required for cardiac conduction system development, plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding. (370 aa) |
| | alcamb | Activated leukocyte cell adhesion molecule b. (562 aa) |
| | spint2 | Serine peptidase inhibitor, Kunitz type, 2. (431 aa) |
| | ppp3r1b | Protein phosphatase 3 (formerly 2B), regulatory s1ubunit B, alpha isoform, b. (170 aa) |
| | atp6v0d1 | V-type proton ATPase subunit d 1; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) p [...] (350 aa) |
| | wnt11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | sostdc1a | Sclerostin domain-containing 1a. (196 aa) |
| | csf1b | Colony-stimulating factor 1b (macrophage). (284 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | ar | Androgen receptor. (868 aa) |
| | dvl3a | Dishevelled segment polarity protein 3a. (676 aa) |
| | hs2st1b | Heparan sulfate 2-O-sulfotransferase 1b. (356 aa) |
| | klhl2 | Kelch-like family member 2. (590 aa) |
| | ccdc85b | Coiled-coil domain-containing protein 85B; Functions as a transcriptional repressor. May inhibit the activity of CTNNB1 in a TP53-dependent manner and thus regulate cell growth (By similarity). May function in adipocyte differentiation, negatively regulating mitotic clonal expansion (By similarity). Plays a role in cell-cell adhesion and epithelium development through its interaction with proteins of the beta-catenin family (Probable). (200 aa) |
| | nipblb | Nipped-B-like protein B; May play a structural role in chromatin. Involved in sister chromatid cohesion, possibly by facilitating the cohesin complex loading. Transcription factor, which may promote cortical neuron migration during brain development by regulating the transcription of crucial genes in this process (By similarity). (2882 aa) |
| | hhip | Hedgehog-interacting protein. (693 aa) |
| | sdc4 | Syndecan 4. (207 aa) |
| | shrprbck1r | RanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('M- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. (714 aa) |
| | kdm6al | Ubiquitously transcribed tetratricopeptide repeat, X chromosome like 1. (1311 aa) |
| | mks1 | MKS transition zone complex subunit 1. (559 aa) |
| | tgfbr2a | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa) |
| | prkacbb | Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa) |
| | glmna | Glomulin, FKBP-associated protein a. (592 aa) |
| | fstb | Follistatin 2. (344 aa) |
| | rad21l1 | RAD21 cohesin complex component-like 1. (546 aa) |
| | ilk | Integrin-linked kinase. (452 aa) |
| | irx1b | Iroquois homeobox protein 1, b. (445 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | F1QAH4_DANRE | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (590 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | hectd1 | Novel protein with HECT-domain (Ubiquitin-transferase). (2576 aa) |
| | srfa | Serum response factor a. (539 aa) |
| | plekhh1 | Pleckstrin homology domain-containing family H member 1; Critical component of the guidance pathway underlying endothelial cell migration and blood vessel patterning. Involved in mediating membrane localization of ephrin proteins, which have been shown to provide guidance cues for endothelial cell migration. (1432 aa) |
| | sox3 | Transcription factor Sox-3; Transcriptional activator. (300 aa) |
| | ccdc103 | Coiled-coil domain-containing protein 103; Dynein-attachment factor required for cilia motility. Belongs to the CCDC103/PR46b family. (247 aa) |
| | bmp4 | Bone morphogenetic protein 4. (400 aa) |
| | scrib | Protein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa) |
| | MYO1D | Unconventional myosin-Id; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in the formation of Kupffer's vesicle, an organ that functions as left-right organizer during embryogenesis. Plays a role in vesicular trafficking events that are required for normal lumen expansion of Kupffer's vesicle. Required for normal orientation of cilia in Kupffer's vesicle, and thus for normal, unidirectional circular flow and normal angular flow velocity, which then mediates asymmetric gene expression and left-right asymmetric developm [...] (1004 aa) |
| | apex1 | DNA-(apurinic or apyrimidinic site) lyase; Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Required for passage through the midblastula trans [...] (310 aa) |
| | nek8 | Serine/threonine-protein kinase Nek8; Required for renal tubular integrity. (697 aa) |
| | ift52 | Intraflagellar transport 52 homolog (Chlamydomonas). (435 aa) |
| | sall4 | Spalt-like transcription factor 4. (1091 aa) |
| | ctsz | Cathepsin Z; Belongs to the peptidase C1 family. (301 aa) |
| | fgf1b | Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (102 aa) |
| | crbn | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa) |
| | ccdc88c | Protein Daple; Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits. This promotes apical cell constriction and subsequent bending of the neural plate during neurulation via arhgef18 (By similarity). (1997 aa) |
| | mthfd1l | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1-like. (978 aa) |
| | sema3ab | Semaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa) |
| | zfpm1 | Zinc finger protein ZFPM1; Transcription regulator that modulates expression mediated by transcription factors of the GATA family. Cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context (By similarity). (1191 aa) |
| | tgfb1a | Transforming growth factor beta; Belongs to the TGF-beta family. (377 aa) |
| | ctsh | Cathepsin H; Belongs to the peptidase C1 family. (330 aa) |
| | fkbp14 | Peptidylprolyl isomerase. (211 aa) |
| | epcam | Epithelial cell adhesion molecule. (303 aa) |
| | bbs5 | Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa) |
| | ctnnbip1 | Catenin, beta-interacting protein 1. (81 aa) |
| | her15.1 | Hairy and enhancer of split-related 15, tandem duplicate 1. (149 aa) |
| | her15.2 | Zgc:136520 protein. (149 aa) |
| | gdf3 | Protein DVR-1; Serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. (355 aa) |
| | atoh8 | Protein atonal homolog 8; Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). During development, is required for heart looping and swim bladder formation by acting in concert with GATA4 AND ZFPM1. During the development of both the retina and skeletal muscles is required for neural retinal cell through modulating PAX6 and NEUROG3 expression and myogenic differentiation. (266 aa) |
| | smad5 | Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa) |
| | tcf21 | Transcription factor 21; Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. (176 aa) |
| | s1pr2 | Sphingosine 1-phosphate receptor 2; Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P receptor is critical for cell migration and epithelial integrity during vertebrate embryogenesis. Receptor for the chemokine-like protein FAM19A5 (By similarity). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). (370 aa) |
| | ube2ia | SUMO-conjugating enzyme UBC9-B; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | vgll2b | Vestigial-like family member 2b. (288 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | phactr4b | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (754 aa) |
| | acvrl1 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (499 aa) |
| | grem1a | Gremlin. (177 aa) |
| | pax2b | Paired box 2b. (386 aa) |
| | abl2 | Tyrosine-protein kinase. (1135 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | pkd1a | Polycystic kidney disease 1a. (4346 aa) |
| | tgfbr2b | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa) |
| | tsc1a | TSC complex subunit 1a. (1128 aa) |
| | pax8 | Paired box 8. (448 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | ttc26 | Intraflagellar transport protein 56; Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Plays a key role in maintaining the integrity of the IFT complex B and the proper ciliary localization of the IFT complex B components. Essential for maintaining proper microtubule organization within the ciliary axoneme (By similarity). Belongs to the IFT56 family. (557 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | wt1a | WT1 transcription factor a. (419 aa) |
| | sap30l | Histone deacetylase complex subunit SAP30L; Functions as transcription repressor, probably via its interaction with histone deacetylase complexes. Required for normal expression of numerous target genes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double- stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3- phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding a [...] (178 aa) |
| | tbx2a | T-box transcription factor 2a. (686 aa) |
| | tcap | Titin-cap (telethonin). (179 aa) |
| | pkd2 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa) |
| | tbx20 | T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa) |
| | tbx3a | T-box transcription factor 3a. (689 aa) |
| | msx3 | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (273 aa) |
| | prkacba | Protein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa) |
| | hand2 | Heart- and neural crest derivatives-expressed protein 2; Essential for myocardial and pectoral fin differentiation, patterning and morphogenesis. (205 aa) |
| | mpp5b | Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa) |
| | noto | Notochord homeobox. (241 aa) |
| | hs6st2 | Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis. (468 aa) |
| | dlx3b | Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa) |
| | mid1ip1b | Mid1-interacting protein 1-B; Involved in stabilization of microtubules. May play a role in the regulation of lipogenesis (By similarity); Belongs to the SPOT14 family. (147 aa) |
| | dvl2 | Dishevelled segment polarity protein 2. (747 aa) |
| | lhx1a | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa) |
| | mthfd1b | Methylenetetrahydrofolate dehydrogenase (NADP+-dependent) 1b. (934 aa) |
| | dag1 | Dystroglycan 1. (866 aa) |
| | foxn4 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] (550 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | bsg | Basigin. (404 aa) |
| | cobl | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal develop [...] (1327 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | tmem59l | Transmembrane protein 59-like. (339 aa) |
| | nkx2.5 | NK2 homeobox 5. (314 aa) |
| | msx1b | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. (257 aa) |
| | sars1 | Serine--tRNA ligase, cytoplasmic; Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the vegfa core promoter and prevents myc binding and transcriptional activation by myc. Thereby inhibits the production of vegfa and sprouting angiogenesis mediated by vegfa. Belongs t [...] (515 aa) |
| | invs | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa) |
| | lbx1b | Ladybird homeobox 1b. (265 aa) |
| | bmp2a | Bone morphogenetic protein 2a. (386 aa) |
| | smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | ube2ib | SUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa) |
| | efhc2 | EF-hand domain-containing family member C2. (748 aa) |
| | rad21a | Double-strand-break repair protein rad21 homolog A; Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post- replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expressio [...] (643 aa) |
| | fgf1a | Putative fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with i [...] (147 aa) |
| | phactr1 | Phosphatase and actin regulator. (542 aa) |
| | spint1b | Serine peptidase inhibitor, Kunitz type 1 b. (499 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | gbx2 | Gastrulation brain homeo box 2. (342 aa) |
| | nrarpb | Notch-regulated ankyrin repeat-containing protein B; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (111 aa) |
| | acvr1l | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa) |
| | tbx16 | T-box transcription factor 16. (470 aa) |
| | prkacab | Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa) |
| | ednraa | Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa) |
