(51 nodes) Positive regulation of leukocyte proliferation network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	ocstamp	Osteoclast stimulatory transmembrane protein. (473 aa)
	syk	Tyrosine-protein kinase. (608 aa)
	zp3	Zona pellucida glycoprotein 3, tandem duplicate 2. (431 aa)
	zap70	Tyrosine-protein kinase. (604 aa)
	sash3	SAM and SH3 domain-containing 3. (386 aa)
	hhla2a.2	HERV-H LTR-associating 2a, tandem duplicate 2. (512 aa)
	tgfbr2b	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (556 aa)
	igf2b	Insulin-like growth factor 2b. (212 aa)
	nck2b	Cytoplasmic protein. (380 aa)
	dhps	Deoxyhypusine synthase. (361 aa)
	nmbr	Neuromedin B receptor; Belongs to the G-protein coupled receptor 1 family. (429 aa)
	tgfbr2a	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (645 aa)
	csf1b	Colony-stimulating factor 1b (macrophage). (284 aa)
	ccl19a.1	C-C motif chemokine. (119 aa)
	nck2a	Cytoplasmic protein. (403 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1130 aa)
	nmbb	Similar to neuromedin B. (136 aa)
	cd40lg	CD40 ligand; Belongs to the tumor necrosis factor family. (260 aa)
	vtcn1	V-set domain-containing T cell activation inhibitor 1. (268 aa)
	il12ba	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (350 aa)
	csf1a	Colony-stimulating factor 1a (macrophage). (526 aa)
	nck1a	NCK adaptor protein 1a. (332 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain-containing adaptor protein. (203 aa)
	zgc:171778	Zona pellucida glycoprotein 3, tandem duplicate 2. (432 aa)
	il34	Si:ch211-239j19.3 protein. (213 aa)
	ccl19b	Chemokine (C-C motif) ligand 19b. (128 aa)
	pth1a	Parathyroid hormone 1a. (102 aa)
	nck1b	Cytoplasmic protein. (381 aa)
	slc7a1a	Solute carrier family 7 member 1a. (652 aa)
	cd276	CD276 molecule. (300 aa)
	il23r	Interleukin 23 receptor. (817 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (826 aa)
	hhla2b.2	HERV-H LTR-associating 2b, tandem duplicate 2. (372 aa)
	csf2rb	Colony-stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage). (696 aa)
	card11	Caspase recruitment domain family, member 11. (1110 aa)
	atad5b	ATPase family AAA domain-containing 5b. (1063 aa)
	il6st	Interleukin 6 signal transducer. (866 aa)
	ENSDARP00000134264	Si:ch211-241b2.5. (465 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (457 aa)
	SLC7A1	Solute carrier family 7 member 1. (647 aa)
	nfatc2a	Nuclear factor of-activated T cells 2a. (894 aa)
	fadd	Fas (tnfrsf6)-associated via death domain. (192 aa)
	il1b	Interleukin-1. (284 aa)
	adgrg1-2	Adhesion G protein-coupled receptor G1. (513 aa)
	LOC110437957	CARD domain-containing protein. (201 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (268 aa)
	ENSDARP00000148508	ecTbetaR2 domain-containing protein. (382 aa)
	ZNF335	Si:ch211-269m15.3. (1534 aa)
	zp3.2	Zona pellucida glycoprotein 3, tandem duplicate 2. (427 aa)
	mpl	MPL proto-oncogene, thrombopoietin receptor. (614 aa)
	cd40	CD40 molecule, TNF receptor superfamily member 5. (286 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSDARP00000134264	cd40	ENSDARP00000134264	ENSDARP00000114636	Si:ch211-241b2.5.	CD40 molecule, TNF receptor superfamily member 5.	0.424
ENSDARP00000134264	vtcn1	ENSDARP00000134264	ENSDARP00000101000	Si:ch211-241b2.5.	V-set domain-containing T cell activation inhibitor 1.	0.594
LOC110437957	fadd	ENSDARP00000146005	ENSDARP00000140007	CARD domain-containing protein.	Fas (tnfrsf6)-associated via death domain.	0.521
adgrg1-2	fadd	ENSDARP00000142726	ENSDARP00000140007	Adhesion G protein-coupled receptor G1.	Fas (tnfrsf6)-associated via death domain.	0.430
card11	ripk2	ENSDARP00000129296	ENSDARP00000134516	Caspase recruitment domain family, member 11.	Receptor-interacting serine-threonine kinase 2.	0.640
card11	syk	ENSDARP00000129296	ENSDARP00000003321	Caspase recruitment domain family, member 11.	Tyrosine-protein kinase.	0.601
card11	zap70	ENSDARP00000129296	ENSDARP00000006727	Caspase recruitment domain family, member 11.	Tyrosine-protein kinase.	0.575
ccl19a.1	ccl19b	ENSDARP00000090385	ENSDARP00000114954	C-C motif chemokine.	Chemokine (C-C motif) ligand 19b.	0.499
ccl19a.1	il12ba	ENSDARP00000090385	ENSDARP00000101046	C-C motif chemokine.	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily.	0.437
ccl19a.1	ptprc	ENSDARP00000090385	ENSDARP00000096384	C-C motif chemokine.	Protein tyrosine phosphatase receptor type C.	0.404
ccl19b	ccl19a.1	ENSDARP00000114954	ENSDARP00000090385	Chemokine (C-C motif) ligand 19b.	C-C motif chemokine.	0.499
ccl19b	cd40	ENSDARP00000114954	ENSDARP00000114636	Chemokine (C-C motif) ligand 19b.	CD40 molecule, TNF receptor superfamily member 5.	0.472
ccl19b	cd40lg	ENSDARP00000114954	ENSDARP00000098917	Chemokine (C-C motif) ligand 19b.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.423
ccl19b	ptprc	ENSDARP00000114954	ENSDARP00000096384	Chemokine (C-C motif) ligand 19b.	Protein tyrosine phosphatase receptor type C.	0.471
ccl19b	tnfsf13b	ENSDARP00000114954	ENSDARP00000147939	Chemokine (C-C motif) ligand 19b.	TNF superfamily member 13b; Belongs to the tumor necrosis factor family.	0.560
cd276	cd40	ENSDARP00000123693	ENSDARP00000114636	CD276 molecule.	CD40 molecule, TNF receptor superfamily member 5.	0.492
cd276	cd40lg	ENSDARP00000123693	ENSDARP00000098917	CD276 molecule.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.595
cd276	vtcn1	ENSDARP00000123693	ENSDARP00000101000	CD276 molecule.	V-set domain-containing T cell activation inhibitor 1.	0.812
cd40	ENSDARP00000134264	ENSDARP00000114636	ENSDARP00000134264	CD40 molecule, TNF receptor superfamily member 5.	Si:ch211-241b2.5.	0.424
cd40	ccl19b	ENSDARP00000114636	ENSDARP00000114954	CD40 molecule, TNF receptor superfamily member 5.	Chemokine (C-C motif) ligand 19b.	0.472

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