Your Input: | |
| | sp3a | Sp3a transcription factor. (679 aa) |
| | rnf2 | E3 ubiquitin-protein ligase RING2; E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin he [...] (338 aa) |
| | ednraa | Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (422 aa) |
| | gdf5 | Growth differentiation factor 5. (474 aa) |
| | epha4l | Eph receptor A4,-like. (988 aa) |
| | cdh2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion (By similarity). Cadherins contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development. Required for normal neural tube morphogenesis. Required to allow mid- and hindbrain neurons to reach and maintain their appropriate positions within the neural tube by restricting neuronal motility within the embryonic mid- and hindbrain. (893 aa) |
| | cldn7b | Claudin-7-B; Plays a major role in tight junction-specific obliteration of the intercellular space; Belongs to the claudin family. (215 aa) |
| | prdm1a | PR domain-containing 1a, with ZNF domain. (776 aa) |
| | gbx2 | Gastrulation brain homeo box 2. (342 aa) |
| | med27 | Mediator of RNA polymerase II transcription subunit 27; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (311 aa) |
| | prkci | Protein kinase C iota type; Calcium- and diacylglycerol-independent serine/ threonine- protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division. (588 aa) |
| | phactr1 | Phosphatase and actin regulator. (542 aa) |
| | jag1b | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. (1213 aa) |
| | efnb2a | Ephrin-B2a; Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with ephb4 may play a central role in heart morph [...] (332 aa) |
| | wnt11f2 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters (By similarity); Belongs to the Wnt family. (353 aa) |
| | bmp2a | Bone morphogenetic protein 2a. (386 aa) |
| | ift57 | Intraflagellar transport protein 57 homolog; Required for the formation of cilia. Essential for differentiation and survival of sensory neurons. May also have pro- apoptotic function. (407 aa) |
| | pax4 | Paired box 4. (344 aa) |
| | msx1b | Homeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. (257 aa) |
| | ttc36 | Tetratricopeptide repeat protein 36; Belongs to the TTC36 family. (187 aa) |
| | gata3 | Transcription factor GATA-3. (438 aa) |
| | myo3b | Myosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1272 aa) |
| | cobl | Protein cordon-bleu; Plays an important role in the reorganization of the actin cytoskeleton. Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. Regulates neuron morphogenesis and increases branching of axons and dendrites (By similarity). Required for normal embryonic development, including normal develop [...] (1327 aa) |
| | fgf8a | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa) |
| | znf503 | Zinc finger protein 503; Required for segmental gene expression during hindbrain development. May function as a transcriptional repressor. Belongs to the Elbow/Noc family. (563 aa) |
| | mab21l2 | Protein mab-21-like 2; Required for eye morphogenesis. May promote the survival of proliferating retinal progenitor cells; Belongs to the mab-21 family. (359 aa) |
| | foxg1b | Forkhead box G1b. (341 aa) |
| | foxn4 | Forkhead box protein N4; Transcription factor essential for neural and some non-neural tissues development. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates. Drives commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the [...] (550 aa) |
| | adgrv1 | Adhesion G-protein coupled receptor V1; Receptor that may have an important role in the development of the sensory nervous system. (6198 aa) |
| | lhx1a | LIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa) |
| | dlx3b | Homeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa) |
| | hs6st2 | Heparan-sulfate 6-O-sulfotransferase 2; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Required for muscle development and angiogenesis. (468 aa) |
| | mpp5b | Membrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5); Belongs to the MAGUK family. (639 aa) |
| | msx3 | Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (273 aa) |
| | tbx3a | T-box transcription factor 3a. (689 aa) |
| | poc1b | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa) |
| | neurod1 | Neurogenic differentiation factor 1; May act as a transcriptional activator. Differentiation factor required for neurogenesis. Acts as an upstream activator of isl1. (350 aa) |
| | meis1a | Myeloid ecotropic viral integration site 4.1a. (380 aa) |
| | tcap | Titin-cap (telethonin). (179 aa) |
| | tbx2a | T-box transcription factor 2a. (686 aa) |
| | igfn1.1 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 1. (534 aa) |
| | crx | Cone-rod homeobox. (281 aa) |
| | six6a | Sine oculis-related homeobox 6a. (245 aa) |
| | med29 | Mediator of RNA polymerase II transcription subunit 29; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). (179 aa) |
| | vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) |
| | tbx5a | T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa) |
| | pax8 | Paired box 8. (448 aa) |
| | OTOP1 | Otopetrin 1. (587 aa) |
| | suv39h1a | Histone-lysine N-methyltransferase SUV39H1-A; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric [...] (411 aa) |
| | aqp1a.1 | Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (260 aa) |
| | vax1 | Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa) |
| | rtn4ip1 | Reticulon-4-interacting protein 1 homolog, mitochondrial; Plays a role in the regulation of retinal ganglion cell (RGC) maturation, neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury (By similarity). Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. (387 aa) |
| | tdrd7a | Tudor domain-containing protein 7A; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). Required for structural integrity of granules in primordial germ cells (PGCs). (1079 aa) |
| | tbx1 | T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa) |
| | dctn2 | Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity). (405 aa) |
| | pax2b | Paired box 2b. (386 aa) |
| | hpn | Novel protein similar to H.sapiens HPN, hepsin (Transmembrane protease, serine 1) (HPN); Belongs to the peptidase S1 family. (425 aa) |
| | phactr4b | Phosphatase and actin regulator 4B; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (754 aa) |
| | tmc2b | Transmembrane channel-like protein 2-B; Belongs to the TMC family. (892 aa) |
| | chrd | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. (940 aa) |
| | tbc1d20 | TBC1 domain family, member 20. (397 aa) |
| | tspan12 | Tetraspanin. (301 aa) |
| | naglu | N-acetylglucosaminidase, alpha. (757 aa) |
| | veph1 | Ventricular zone-expressed PH domain-containing protein. (813 aa) |
| | wnt8b | Protein Wnt-8b; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. May play a role in the establishment of polarity in the nervous system. (358 aa) |
| | znf703 | Zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Required for segmental gene expression during hindbrain development. May regulate cell adhesion, migration and proliferation. (589 aa) |
| | vgll2b | Vestigial-like family member 2b. (288 aa) |
| | pitx2 | Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa) |
| | smad5 | Mothers against decapentaplegic homolog 5; Involved in ventralization. May mediate Bmp2b signaling during early phases of embryonic dorsal-ventral pattern formation. Required for initiation of Smad1 expression during gastrulation. Belongs to the dwarfin/SMAD family. (464 aa) |
| | egr1 | Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa) |
| | bhlhe23 | Basic helix-loop-helix family, member e23. (227 aa) |
| | nkx3-2 | Bagpipe homeobox transcription factor Bapx1. (245 aa) |
| | ascl1a | Achaete-scute homolog 1a; Transcriptional regulator. May mediate transcription activation by binding to the E box-containing promoter (By similarity). Involved in neurogenesis. Required for the development of neurons in the epiphysis, acting partially redundantly with neurog1 and downstream of flh. Involved in maintaining rhombomere boundaries in the hindbrain, probably via up-regulation of delta expression. Also involved in pituitary development; required cell-autonomously in adenohypophyseal cells for endocrine differentiation and for survival of a subset of cells. (196 aa) |
| | pacsin1b | Protein kinase C and casein kinase substrate in neurons protein 1; Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in cellular transport processes by recruiting dynamins to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with cobl, and by recruiting cobl to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neur [...] (445 aa) |
| | bbs5 | Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa) |
| | rx2 | Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (327 aa) |
| | myo6b | Myosin VIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1267 aa) |
| | crbn | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (446 aa) |
| | otx1 | Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa) |
| | rx3 | Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa) |
| | gdf6a | Growth/differentiation factor 6-A; Growth factor that controls proliferation and cellular differentiation in the retina. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Functions maternally in dorsal/ventral patterning to induce the expression of the zygotic bmp2b and bmp4 genes and ventralize embryos. Zygotic expression does not appear to regulate axis specification, but instead functions to establish the integrity of the axial vessels during embryon [...] (404 aa) |
| | sox3 | Transcription factor Sox-3; Transcriptional activator. (300 aa) |
| | pax2a | Paired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa) |
| | six3b | Sine oculis homeobox homolog 3b. (293 aa) |
| | zhx2a | Zinc fingers and homeoboxes 2a. (805 aa) |
| | foxc1b | Forkhead box C1-B; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (433 aa) |
| | foxh1 | Forkhead box protein H1; Transcriptional activator. Activates an activin response element (ARE). Recognizes and binds to the DNA sequence 5'- TGT[GT][GT]ATT-3'. Modulator of nodal signaling required for organizer formation. Also required for the development of dorsal axial structures and left-right symmetry. (472 aa) |
| | suv39h1b | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa) |
| | dzank1 | Double zinc ribbon and ankyrin repeat domains 1. (752 aa) |
| | fstb | Follistatin 2. (344 aa) |
| | six3a | Sine oculis homeobox homolog 3a. (294 aa) |
| | ttc25 | Tetratricopeptide repeat protein 25; Required for the docking of the outer dynein arm to cilia, hence plays an essential role in cilia motility. (486 aa) |
| | bves | Blood vessel epicardial substance; Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in skeletal muscle and heart development as well as in the maintenance of heart function. May play a role in vamp3-mediated vesicular transport and recycling of receptor molecules. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. May induce primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)- independent manner. May be involved in epithelial movement during [...] (352 aa) |
| | vax2 | Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa) |
| | gata2a | GATA-binding protein 2a. (456 aa) |
| | kcnq1.1 | Potassium voltage-gated channel, KQT-like subfamily, member 1.1; Belongs to the potassium channel family. (655 aa) |
| | shrprbck1r | RanBP-type and C3HC4-type zinc finger-containing protein 1; Component of the LUBAC complex which conjugates linear ('M- 1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. (714 aa) |
| | crb2a | Crumbs cell polarity complex component 2a. (1466 aa) |
| | nectin1b | Nectin cell adhesion molecule 1b. (539 aa) |
| | efnb2b | Ephrin-B2b; Belongs to the ephrin family. (334 aa) |
| | rorb | RAR-related orphan receptor B. (466 aa) |
| | ptk7a | Protein tyrosine kinase 7a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1061 aa) |
| | tcf7l1a | Transcription factor 7-like 1-A; Participates in the Wnt signaling pathway. Probably binds to DNA and acts as a repressor in the absence of ctnnb1, and possibly as an activator in its presence. Required early in development for dorsal specific gene activation and during gastrulation for repression of dorsal-specific genes in the marginal zone. Required for head formation and forebrain specification. Regulates anterior-posterior patterning in the neuroectoderm by repressing posterior neural fates. Belongs to the TCF/LEF family. (560 aa) |
| | alcamb | Activated leukocyte cell adhesion molecule b. (562 aa) |
| | atoh7 | Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. (134 aa) |
| | six7 | Sine oculis homeobox homolog 7. (256 aa) |
| | foxg1a | Forkhead box G1a. (420 aa) |
| | sox2 | Transcription factor Sox-2; Transcriptional activator. May function as a switch in neuronal development (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). (315 aa) |
| | hmx3a | Homeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa) |
| | abhd12 | Lysophosphatidylserine lipase ABHD12; Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase act [...] (382 aa) |
| | edn1 | Endothelin 1. (188 aa) |
| | stm | Protein starmaker; Essential for the formation of otoliths in the inner ear of developing larvae and for the perception of gravity and acceleration. May be one of the organic components of the ortholiths. (613 aa) |
| | rom1b | Retinal outer segment membrane protein 1b. (352 aa) |
| | dlx4b | Homeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa) |
| | rx1 | Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (330 aa) |
| | lrig1 | Leucine-rich repeats and immunoglobulin-like domains 1. (1022 aa) |
| | foxg1d | Forkhead box G1d. (316 aa) |
| | sdk1a | Sidekick cell adhesion molecule 1a. (2159 aa) |
| | tdrd7b | Tudor domain-containing protein 7B; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Probably required during spermatogenesis (By similarity). (1085 aa) |
| | whrna | Whirlin a. (939 aa) |
| | nectin1a | Nectin cell adhesion molecule 1a. (475 aa) |
| | bbs4 | Bardet-Biedl syndrome 4. (528 aa) |
| | ush1c | Usher syndrome 1C (Autosomal recessive, severe). (548 aa) |
| | foxc1a | Forkhead box C1-A; DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Required for cell viability and resistance to oxidative stress in the eye. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1- mediated signals. Involved in epithelia [...] (476 aa) |
| | hmgn6 | High mobility group nucleosome-binding domain 6. (93 aa) |
| | foxj1b | Forkhead box protein J1-B; Key transcription factor required for motile ciliogenesis. Activates genes essential for motile cilia formation and function. Belongs to the FOXJ1 family. (442 aa) |
| | rpgrip1l | RPGRIP1-like. (1256 aa) |
| | adgrg2a | Adhesion G protein-coupled receptor G2a; Belongs to the G-protein coupled receptor 2 family. (1037 aa) |
| | bmp2b | Bone morphogenetic protein 2b. (411 aa) |
| | tbx2b | T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa) |
| | reep6 | Receptor expression-enhancing protein 6; Required correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity). (208 aa) |
| | insm1a | Insulinoma-associated protein 1a; May act as a transcriptional regulator. May play a role in neurogenesis and neuroendocrine cell differentiation during embryonic development (By similarity). (383 aa) |
| | rab11fip4a | Rab11 family-interacting protein 4A; Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis (By similarity). May play a role in differentiation during retinal development. (621 aa) |
| | hmx2 | H6 family homeobox 2. (269 aa) |
| | tbx3b | T-box transcription factor 3b. (594 aa) |
| | aqp1a.2 | Aquaporin 1a (Colton blood group), tandem duplicate 2; Belongs to the MIP/aquaporin (TC 1.A.8) family. (269 aa) |
| | six6b | Sine oculis-related homeobox 6b. (245 aa) |
| | mfrp | Membrane frizzled-related protein. (572 aa) |
| | tmie | Transmembrane inner ear. (231 aa) |
| | myo6a | Myosin VIa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1288 aa) |
| | foxg1c | Forkhead box G1c. (379 aa) |
| | myo3a | Myosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1775 aa) |
| | pax5 | Paired box 5. (396 aa) |
| | rp1 | RP1 axonemal microtubule-associated. (259 aa) |
| | cthrc1a | Collagen triple helix repeat-containing 1a. (232 aa) |
| | ptprq | Protein tyrosine phosphatase receptor type Q. (2301 aa) |
| | adgrg6 | Adhesion G-protein coupled receptor G6; G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins. Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Plays also a role in inner ear development. (1240 aa) |
| | sdk1b | Sidekick cell adhesion molecule 1b. (2095 aa) |
| | sdk2b | Sidekick cell adhesion molecule 2b. (2237 aa) |
| | cthrc1b | Collagen triple helix repeat-containing 1b. (233 aa) |
| | rpgrip1 | RPGR-interacting protein 1. (1342 aa) |
| | impg2a | Interphotoreceptor matrix proteoglycan 2a. (270 aa) |
| | foxq2 | Forkhead box Q2. (263 aa) |
| | whrnb | Whirlin b. (946 aa) |
| | hnf1ba | Hepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa) |
| | nf1b | Neurofibromin 1b. (2759 aa) |
| | gata2b | GATA-binding protein 2b. (428 aa) |
| | rp2 | Protein XRP2; Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane (By similarity). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization (By similarity). In the retina, required for maintenance of rod and cone photoreceptor cells. May have a role in normal retinal localization of the transducins GNB1 and GNAT1, and the rhodopsin kinase GRK1. (376 aa) |
| | mdn1 | Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (5523 aa) |
| | F1QB00_DANRE | Si:dkey-259j3.5; Belongs to the G-protein coupled receptor 2 family. (720 aa) |
| | adgrg4b | Adhesion G protein-coupled receptor G4b; Belongs to the G-protein coupled receptor 2 family. (522 aa) |
| | fsta | Follistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa) |
| | mpp5a | MAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | ahi1 | Abelson helper integration site 1. (1193 aa) |
| | ednrab | Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | cep290 | Centrosomal protein of 290 kDa; Involved in early and late steps in cilia formation. May play a role in early ciliogenesis in the disappearance of centriolar satellites and in the transition of primary ciliar vesicles (PCVs) to capped ciliary vesicles (CCVs). In the ciliary transition zone is part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in regulation of the BBSome complex integrity and in ciliary targeting of selected BBSome cargos. Required for the correct localization of ciliary and photot [...] (2439 aa) |
| | shha | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (418 aa) |
| | sp3b | Sp3b transcription factor. (649 aa) |
| | igfn1.2 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 2. (1409 aa) |
| | nf1a | Neurofibromin 1a. (2759 aa) |
| | igfn1.4 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 4. (1230 aa) |
| | wdpcp | WD repeat-containing planar cell polarity effector. (707 aa) |
| | igfn1.3 | Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 3. (1355 aa) |
| | agtpbp1 | Cytosolic carboxypeptidase 1; Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate. (1153 aa) |
| | med24 | Mediator of RNA polymerase II transcription subunit 24; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required [...] (989 aa) |
| | crb2b | Crumbs cell polarity complex component 2b. (1010 aa) |
| | fgf3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (256 aa) |
| | mib1 | E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa) |
| | fgf2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa) |
| | impg2b | Interphotoreceptor matrix proteoglycan 2b. (353 aa) |
| | tprn | Taperin. (758 aa) |
| | impg2b-2 | Interphotoreceptor matrix proteoglycan 2b. (428 aa) |
| | ttc39c | Tetratricopeptide repeat protein 39C. (579 aa) |
| | gas8 | Dynein regulatory complex subunit 4; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker (By similarity). Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper slow muscle development and positively regulates ciliary smoothened (SMO)-dependent Hedgehog ( [...] (475 aa) |
| | axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) |
| | pax6a | Paired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa) |
| | agbl1 | ATP/GTP-binding protein-like 1. (1028 aa) |
| | slc44a4 | Choline transporter-like protein 4; Choline transporter that seems to play a role in the choline- acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury; Belongs to the CTL (choline transporter-like) family. (703 aa) |
| | crb1 | Crumbs cell polarity complex component 1. (1428 aa) |
| | faslg | Fas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa) |
| | phactr4a | Phosphatase and actin regulator 4A. (1011 aa) |
| | kif22 | Kinesin-like protein KIF22; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. (634 aa) |
| | nbl1 | Neuroblastoma suppressor of tumorigenicity 1; May act as a tumor suppressor; Belongs to the DAN family. (86 aa) |
| | mab21l1 | Putative nucleotidyltransferase MAB21L1; Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity). Belongs to the mab-21 family. (359 aa) |
| | sdk2a | Sidekick cell adhesion molecule 2a. (2170 aa) |
| | slitrk6 | SLIT and NTRK-like family, member 6. (830 aa) |
| | zgc:153993 | Zgc:153993 protein. (204 aa) |
| | pdzd7a | PDZ domain-containing 7a. (954 aa) |
| | tatdn1 | Putative deoxyribonuclease TATDN1; Putative deoxyribonuclease. (185 aa) |
| | ttc8 | Tetratricopeptide repeat domain 8. (268 aa) |
| | clrn1 | Clrn1 protein. (232 aa) |
| | ccnd1 | G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa) |
| | zgc:63863 | Zgc:63863. (399 aa) |
| | LOC568600 | FAT atypical cadherin 3b. (4362 aa) |
| | kcnq1.2 | Potassium voltage-gated channel, KQT-like subfamily, member 1.2; Belongs to the potassium channel family. (531 aa) |
| | adgrg4a | Adhesion G protein-coupled receptor G4a; Belongs to the G-protein coupled receptor 2 family. (1201 aa) |
| | nkd1 | Protein naked cuticle homolog 1; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity); Belongs to the NKD family. (440 aa) |
| | si:ch73-40a2.1 | Si:ch73-40a2.1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (723 aa) |
| | eys-2 | Protein eyes shut homolog; Required to maintain the integrity of photoreceptor cells. Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone. Belongs to the EYS family. (296 aa) |
| | phactr4a-2 | Phosphatase and actin regulator 4A; Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to repression of the integrin signaling through the rho/rock pathway (By similarity). (118 aa) |
| | bloc1s5 | Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (155 aa) |
| | atf4a | Cyclic AMP-dependent transcription factor ATF-4; Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. May play a role in the regulation of the circadian clock (By similarity). (339 aa) |
| | ENSDARP00000147138 | TGFb_propeptide domain-containing protein. (179 aa) |
| | msx1a | Muscle segment homeobox 1a. (233 aa) |
| | pacsin1a | Protein kinase C and casein kinase substrate in neurons 1a. (438 aa) |
| | prdm1b | PR domain-containing 1b, with ZNF domain. (471 aa) |
| | wdr19 | WD repeat domain 19. (1372 aa) |
| | fat3a | FAT atypical cadherin 3a. (4601 aa) |
| | strc1 | Stereocilin 1. (2032 aa) |
| | pax6b | Paired box 6b. (450 aa) |
| | thrb | Thyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa) |
| | alcama | CD166 antigen homolog A; Cell adhesion molecule that mediates both heterotypic cell- cell contacts via its interaction with CD6, as well as homotypic cell- cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothel [...] (564 aa) |
| | ENSDARP00000153246 | Ig-like domain-containing protein. (160 aa) |
| | CABP4 | Si:cabz01076231.1. (218 aa) |
| | fjx1 | Four-jointed box kinase 1. (397 aa) |
| | mfap5 | Microfibril-associated protein 5. (131 aa) |
| | ubr3 | E3 ubiquitin-protein ligase ubr3; E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (By similarity). Recognizes and binds to proteins bearing specific N-terminal residues, leading to their ubiquitination and subsequent degradation (By similarity). Positively regulates hedgehog/shh-signaling pathways that function in eye development, neuronal specification and somite development. Activation of shh up-regulates transcription of ubr3, which in turn promotes hedgehog/shh signaling possibly by controlling negative regulators such as Kif7. (1863 aa) |
