(23 nodes) Regulation of plasma lipoprotein particle levels network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	apom	Apolipoprotein M. (215 aa)
	soat2	Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family. (569 aa)
	pltp	Phospholipid transfer protein. (486 aa)
	lcat	Lecithin-cholesterol acyltransferase. (425 aa)
	zgc:92162	Phospholipase A(2). (153 aa)
	apoea	Apolipoprotein Ea. (269 aa)
	LOC101884800	PLAT domain-containing protein. (530 aa)
	dgat1a	O-acyltransferase. (499 aa)
	scarb1	Scavenger receptor class B, member 1; Belongs to the CD36 family. (496 aa)
	adipoqb	Adiponectin, C1Q and collagen domain-containing, b. (299 aa)
	LOC100331214	PLAT domain-containing protein. (502 aa)
	lpcat3	Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (465 aa)
	dgat1b	O-acyltransferase. (507 aa)
	lpl	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (511 aa)
	lipca	Lipase, hepatic a. (514 aa)
	apoba	Apolipoprotein Ba. (4418 aa)
	apoeb	Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
	ldlrap1b	Low density lipoprotein receptor adaptor protein 1b. (304 aa)
	cd36	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
	cetp	Cholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
	apoa1a	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). (262 aa)
	mttp	Microsomal triglyceride transfer protein large subunit; Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B. (884 aa)
	soat1	O-acyltransferase. (554 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC100331214	LOC101884800	ENSDARP00000153290	ENSDARP00000135122	PLAT domain-containing protein.	PLAT domain-containing protein.	0.903
LOC100331214	adipoqb	ENSDARP00000153290	ENSDARP00000141357	PLAT domain-containing protein.	Adiponectin, C1Q and collagen domain-containing, b.	0.598
LOC100331214	apoa1a	ENSDARP00000153290	ENSDARP00000025613	PLAT domain-containing protein.	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	0.453
LOC100331214	lipca	ENSDARP00000153290	ENSDARP00000069990	PLAT domain-containing protein.	Lipase, hepatic a.	0.659
LOC100331214	lpl	ENSDARP00000153290	ENSDARP00000109101	PLAT domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.903
LOC101884800	LOC100331214	ENSDARP00000135122	ENSDARP00000153290	PLAT domain-containing protein.	PLAT domain-containing protein.	0.903
LOC101884800	adipoqb	ENSDARP00000135122	ENSDARP00000141357	PLAT domain-containing protein.	Adiponectin, C1Q and collagen domain-containing, b.	0.598
LOC101884800	apoa1a	ENSDARP00000135122	ENSDARP00000025613	PLAT domain-containing protein.	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	0.453
LOC101884800	lipca	ENSDARP00000135122	ENSDARP00000069990	PLAT domain-containing protein.	Lipase, hepatic a.	0.663
LOC101884800	lpl	ENSDARP00000135122	ENSDARP00000109101	PLAT domain-containing protein.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.901
adipoqb	LOC100331214	ENSDARP00000141357	ENSDARP00000153290	Adiponectin, C1Q and collagen domain-containing, b.	PLAT domain-containing protein.	0.598
adipoqb	LOC101884800	ENSDARP00000141357	ENSDARP00000135122	Adiponectin, C1Q and collagen domain-containing, b.	PLAT domain-containing protein.	0.598
adipoqb	apoba	ENSDARP00000141357	ENSDARP00000062792	Adiponectin, C1Q and collagen domain-containing, b.	Apolipoprotein Ba.	0.451
adipoqb	cd36	ENSDARP00000141357	ENSDARP00000050752	Adiponectin, C1Q and collagen domain-containing, b.	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family.	0.519
adipoqb	lpl	ENSDARP00000141357	ENSDARP00000109101	Adiponectin, C1Q and collagen domain-containing, b.	Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.	0.628
adipoqb	scarb1	ENSDARP00000141357	ENSDARP00000137986	Adiponectin, C1Q and collagen domain-containing, b.	Scavenger receptor class B, member 1; Belongs to the CD36 family.	0.405
apoa1a	LOC100331214	ENSDARP00000025613	ENSDARP00000153290	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	PLAT domain-containing protein.	0.453
apoa1a	LOC101884800	ENSDARP00000025613	ENSDARP00000135122	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	PLAT domain-containing protein.	0.453
apoa1a	apoba	ENSDARP00000025613	ENSDARP00000062792	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	Apolipoprotein Ba.	0.977
apoa1a	apoea	ENSDARP00000025613	ENSDARP00000133853	Proapolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT).	Apolipoprotein Ea.	0.794

page 1 of 9

Server load: low (28%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About