STRINGSTRING
itprip itprip tnfb tnfb gsk3ab gsk3ab hdr hdr baxa baxa tnfa tnfa gsk3ba gsk3ba bcl2l1 bcl2l1 tradd tradd LOC794408 LOC794408 rnf41 rnf41 skila skila bag3 bag3 tgfb1a tgfb1a p2rx7 p2rx7 dedd1 dedd1 gsk3bb gsk3bb badb badb F1QQY3_DANRE F1QQY3_DANRE fas fas tnfsf12 tnfsf12 casp8 casp8 tgfb5 tgfb5 bcl2l11 bcl2l11 rb1cc1 rb1cc1 mcl1a mcl1a Ifi27.3 Ifi27.3 g0s2 g0s2 tnfrsf1b tnfrsf1b daxx daxx skilb skilb tnfrsfa tnfrsfa casp2 casp2 bcl2l10 bcl2l10 gsk3aa gsk3aa parp2 parp2 nf1b nf1b casp8ap2 casp8ap2 tgfb1b tgfb1b pidd1 pidd1 bokb bokb tgfb2 tgfb2 boka boka mcl1b mcl1b LOC100004321 LOC100004321 nf1a nf1a dele1 dele1 ddx47 ddx47 casp20 casp20 casp22 casp22 faslg faslg zgc:153993 zgc:153993 fadd fadd casp10 casp10 siva1 siva1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
itpripInositol 1,4,5-trisphosphate receptor-interacting protein; Enhances Ca(2+)-mediated inhibition of inositol 1,4,5- triphosphate receptor (ITPR) Ca(2+) release. Belongs to the ITPRIP family. (539 aa)
tnfbTumor necrosis factor b (TNF superfamily, member 2). (242 aa)
gsk3abGlycogen synthase kinase 3 alpha b; Belongs to the protein kinase superfamily. (440 aa)
hdrHematopoietic death receptor. (418 aa)
baxaBCL2-associated X, apoptosis regulator a. (192 aa)
tnfaTumor necrosis factor a (TNF superfamily, member 2). (234 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
bcl2l1Bcl-XL-like protein 1. (238 aa)
traddTumor necrosis factor receptor type 1-associated DEATH domain protein; Adapter molecule for tnfrsf1a that specifically associates with the cytoplasmic domain of activated tnfrsf1a mediating its interaction with fadd. (293 aa)
LOC794408Si:dkeyp-80c12.4. (687 aa)
rnf41E3 ubiquitin-protein ligase NRDP1; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. (318 aa)
skilaSKI-like proto-oncogene a. (623 aa)
bag3BCL2-associated athanogene 3. (480 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
p2rx7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (596 aa)
dedd1Death effector domain-containing 1. (369 aa)
gsk3bbGlycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa)
badbBCL2-associated agonist of cell death b. (147 aa)
F1QQY3_DANRESortilin. (423 aa)
fasFas cell surface death receptor. (293 aa)
tnfsf12Tumor necrosis factor superfamily member 12; Belongs to the tumor necrosis factor family. (236 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
bcl2l11BCL2-like 11. (176 aa)
rb1cc1RB1-inducible coiled-coil 1. (1622 aa)
mcl1aMCL1 apoptosis regulator, BCL2 family member a. (255 aa)
Ifi27.3Si:dkey-188i13.6. (126 aa)
g0s2Hypothetical LOC568476. (162 aa)
tnfrsf1bTumor necrosis factor receptor superfamily, member 1B. (425 aa)
daxxDeath-domain-associated protein. (716 aa)
skilbSKI-like proto-oncogene b. (624 aa)
tnfrsfaTumor necrosis factor receptor superfamily, member a. (436 aa)
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (399 aa)
bcl2l10BCL2-like 10 (Apoptosis facilitator). (176 aa)
gsk3aaGlycogen synthase kinase 3 alpha a; Belongs to the protein kinase superfamily. (462 aa)
parp2Poly [ADP-ribose] polymerase. (649 aa)
nf1bNeurofibromin 1b. (2759 aa)
casp8ap2Caspase 8-associated protein 2. (1995 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
pidd1P53-induced death domain protein 1. (942 aa)
bokbBcl-2-related ovarian killer protein homolog B; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. (214 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
bokaBcl-2-related ovarian killer protein homolog A; May play a role in apoptosis. Does not appear to show pro- apoptotic activity when expressed ectopically in early embryos. Belongs to the Bcl-2 family. (224 aa)
mcl1bMCL1 apoptosis regulator, BCL2 family member b. (228 aa)
LOC100004321BCL2-associated X, apoptosis regulator a. (197 aa)
nf1aNeurofibromin 1a. (2759 aa)
dele1DAP3-binding cell death enhancer 1. (208 aa)
ddx47DEAD (Asp-Glu-Ala-Asp) box polypeptide 47. (270 aa)
casp20Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (347 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
faslgFas ligand (TNF superfamily, member 6); Belongs to the tumor necrosis factor family. (268 aa)
zgc:153993Zgc:153993 protein. (204 aa)
faddFas (tnfrsf6)-associated via death domain. (192 aa)
casp10Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (548 aa)
siva1SIVA1, apoptosis-inducing factor. (172 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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