STRINGSTRING
casp2 casp2 caspbl caspbl cflarb cflarb casp20 casp20 casp22 casp22 casp10 casp10 casp23 casp23 caspa caspa casp9 casp9 pycard pycard caspb caspb cflara cflara casp8 casp8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
casp2Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (399 aa)
caspblCaspase b,-like; Belongs to the peptidase C14A family. (409 aa)
cflarbCASP8 and FADD-like apoptosis regulator b. (178 aa)
casp20Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (347 aa)
casp22Caspase 22, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (376 aa)
casp10Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (548 aa)
casp23Caspase 23, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (446 aa)
caspaCaspase a subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form. Its subsequent activation causes the cleavage of pro-il1b into the midformed il1b, which then evetually leads to il1b maturation and secretion in the extracellular milieu. Required for the [...] (383 aa)
casp9Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (436 aa)
pycardApoptosis-associated speck-like protein containing a CARD; Functions as key mediator in apoptosis and inflammation. Promotes caspase-mediated apoptosis. Induces proteolytic processing of caspa and caspa- dependent apoptosis. In innate immune response acts as an integral adapter in the assembly of NLRP1 inflammasomes which activate caspases caspa and caspb leading to processing and secretion of the proinflammatory cytokine il1b. The function as activating adapter in different types of inflammasomes is mediated by the pyrin and CARD domains and their homotypic interactions. Also involved [...] (203 aa)
caspbCaspase b subunit p10; Thiol protease which cleaves IL-1 beta (il1b), releasing the mature cytokine which is involved in a variety of inflammatory processes, and mediates apoptosis. Component of the NLRP1 inflammasome, which plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, recruited to the NLRP1 inflammasome in its precursor form following the recruitment of caspase caspa. Its subsequent activation causes the cleavage of the midformed pro-il1b and results in il1b maturation and secretion in the extracellular milieu. [...] (404 aa)
cflaraCASP8 and FADD-like apoptosis regulator a; Belongs to the peptidase C14A family. (461 aa)
casp8Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (476 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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