STRINGSTRING
parp1 parp1 arid2 arid2 epc2 epc2 zgc:101810 zgc:101810 brd8 brd8 wdr48b wdr48b dmap1 dmap1 rad51ap1 rad51ap1 yeats4 yeats4 actr2a actr2a pogza pogza epc1b epc1b vps72a vps72a fancb fancb actr2b actr2b pias4a pias4a timeless timeless hdgfl2 hdgfl2 helq helq wrap53 wrap53 mrgbp mrgbp E9QG94_DANRE E9QG94_DANRE mrnip mrnip ercc6 ercc6 pogzb pogzb mms19 mms19 epc1a epc1a wdr48a wdr48a trrap trrap vps72b vps72b ENSDARP00000157149 ENSDARP00000157149
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
arid2AT-rich interactive domain 2 (ARID, RFX-like). (1572 aa)
epc2Enhancer of polycomb homolog. (751 aa)
zgc:101810Zgc:101810; Belongs to the actin family. (394 aa)
brd8Bromodomain-containing 8. (840 aa)
wdr48bWD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa)
dmap1DNA methyltransferase 1-associated protein 1. (464 aa)
rad51ap1RAD51-associated protein 1. (347 aa)
yeats4YEATS domain-containing 4. (226 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
pogzaPogo transposable element-derived with ZNF domain a. (1277 aa)
epc1bEnhancer of polycomb homolog. (797 aa)
vps72aVacuolar protein sorting 72 homolog a. (369 aa)
fancbFA complementation group B. (796 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
pias4aE3 SUMO-protein ligase PIAS4-A; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase (By similarity). May play a role as a transcriptional coregulator in various cellular pathways (By similarity). Negatively regulates induction of interferon phi 1 (ifnphi1) mediated by mavs and ticam1/trif. Also inhibits ifnphi1-mediated activation of the interferon-stimulated genes (ISGs) pkz and cd40, and to a lesser extent rsad2 and isg15. May inhibit ticam1/trif-mediated activation of NF-kappa-B. (508 aa)
timelessTimeless circadian clock. (1278 aa)
hdgfl2Hepatoma-derived growth factor-related protein 2; Belongs to the HDGF family. (662 aa)
helqHelicase, POLQ-like. (1010 aa)
wrap53WD repeat-containing, antisense to TP53. (534 aa)
mrgbpC20orf20 homolog (H. sapiens). (205 aa)
E9QG94_DANRESi:ch211-59d17.3. (816 aa)
mrnipMRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair; Belongs to the MRNIP family. (392 aa)
ercc6Excision repair cross-complementation group 6. (1389 aa)
pogzbPogo transposable element-derived with ZNF domain b. (1924 aa)
mms19MMS19 nucleotide excision repair protein homolog; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins (By similarity). (1016 aa)
epc1aEnhancer of polycomb homolog. (796 aa)
wdr48aWD repeat domain 48a. (524 aa)
trrapTransformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family. (3841 aa)
vps72bVacuolar protein sorting 72 homolog b. (366 aa)
ENSDARP00000157149WD_REPEATS_REGION domain-containing protein. (519 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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