STRINGSTRING
LOC553528 LOC553528 fgfr4 fgfr4 dhx36 dhx36 sox5 sox5 rbm24a rbm24a ddx46 ddx46 sirt6 sirt6 pus7 pus7 eif2ak2 eif2ak2 rbm24b rbm24b sox6 sox6 fgfr2 fgfr2 tgfb2 tgfb2 nsun2 nsun2 ythdf2 ythdf2 nfe2l2b nfe2l2b slc4a11 slc4a11 cdk13 cdk13 tgfb5 tgfb5 smyd5 smyd5 nkx2.5 nkx2.5 fgfr3 fgfr3 hspa9 hspa9 pwp1 pwp1 ociad1 ociad1 dld dld cdk12 cdk12 nfe2l2a nfe2l2a supt5h supt5h epcam epcam pkz pkz mettl3 mettl3 nudt21 nudt21 bbs12 bbs12 npas4l npas4l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC553528OCIA domain-containing protein. (239 aa)
fgfr4Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa)
dhx36DEAH (Asp-Glu-Ala-His) box polypeptide 36. (1037 aa)
sox5SRY-box transcription factor 5. (759 aa)
rbm24aRNA-binding protein 24; Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation. Plays a major role in pre-mRNA alternative splicing regulation. Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation. Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing. Involved in embry [...] (230 aa)
ddx46Probable ATP-dependent RNA helicase DDX46; Plays an essential role in splicing, either prior to, or during A complex formation; Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (1018 aa)
sirt6Sirtuin (Silent mating type information regulation 2 homolog) 6 (S. cerevisiae). (354 aa)
pus7Pseudouridine synthase 7. (627 aa)
eif2ak2Eukaryotic translation initiation factor 2-alpha kinase 2. (682 aa)
rbm24bRNA-binding motif protein 24b. (245 aa)
sox6SRY-box transcription factor 6. (816 aa)
fgfr2Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa)
tgfb2Transforming growth factor, beta 2. (413 aa)
nsun2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (766 aa)
ythdf2YTH domain-containing family protein 2; Specifically recognizes and binds N6-methyladenosine (m6A)- containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing (By similarity). Plays a key role in maternal-to-zygotic transition during early embryonic development, the process during which maternally inherited mRNAs are degraded: acts by binding m6A-containing maternal mRNAs and promoting their degradation. More than one-third of maternal mRNAs can be modified by m6A. Bi [...] (613 aa)
nfe2l2bNuclear factor, erythroid 2-like 2b. (507 aa)
slc4a11Solute carrier family 4 member 11. (846 aa)
cdk13Cyclin-dependent kinase 13. (1289 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
smyd5SMYD family member 5. (415 aa)
nkx2.5NK2 homeobox 5. (314 aa)
fgfr3Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa)
hspa9Heat shock protein 9; Belongs to the heat shock protein 70 family. (682 aa)
pwp1PWP1 homolog (S. cerevisiae). (490 aa)
ociad1OCIA domain-containing protein 1. (266 aa)
dldDelta-like protein D; Acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. Can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. Required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized. (717 aa)
cdk12Cyclin-dependent kinase 12. (1293 aa)
nfe2l2aNuclear factor (Erythroid-derived 2)-like 2. (586 aa)
supt5hTranscription elongation factor SPT5; May function as a component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II. Probably enhances transcriptional pausing at sites proximal to the promoter, which may facilitate the assembly of an elongation competent RNA polymerase II complex. Also acts to stimulate transcriptional elongation at low nucleotide concentrations. Regulation of transcriptional elongation by this protein is required for the expression of genes which control neuronal development. Belongs to the SPT [...] (1084 aa)
epcamEpithelial cell adhesion molecule. (303 aa)
pkzProtein kinase-containing Z-DNA-binding domains. (511 aa)
mettl3N6-adenosine-methyltransferase subunit METTL3; The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing. In the heterodimer formed with mettl14, mettl3 constitutes the catalytic core (By similarity). N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some [...] (584 aa)
nudt21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (228 aa)
bbs12Bardet-Biedl syndrome 12. (763 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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