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pot1 pot1 nsd2 nsd2 parp3 parp3 prkdc prkdc zgc:101664 zgc:101664 dek dek kmt5b kmt5b hmga2 hmga2 fh fh setmar setmar wrap53 wrap53 kmt5c kmt5c zgc:66440 zgc:66440 rif1 rif1 si:dkey-3h3.3 si:dkey-3h3.3 mrnip mrnip ercc6 ercc6 E7FGN5_DANRE E7FGN5_DANRE X1WFS5_DANRE X1WFS5_DANRE X1WG91_DANRE X1WG91_DANRE E7FBV5_DANRE E7FBV5_DANRE pnkp pnkp ENSDARP00000135458 ENSDARP00000135458 Aunip Aunip smchd1 smchd1 LOC100535417 LOC100535417 sirt7 sirt7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pot1Protection of telomeres 1 homolog. (773 aa)
nsd2Nuclear receptor-binding SET domain protein 2. (1461 aa)
parp3Poly [ADP-ribose] polymerase. (531 aa)
prkdcProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4119 aa)
zgc:101664Zgc:101664. (205 aa)
dekDEK proto-oncogene. (443 aa)
kmt5bHistone-lysine N-methyltransferase KMT5B; Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromat [...] (808 aa)
hmga2High mobility group AT-hook 2. (110 aa)
fhFumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (By similarity). Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting [...] (509 aa)
setmarSET domain and mariner transposase fusion protein. (293 aa)
wrap53WD repeat-containing, antisense to TP53. (534 aa)
kmt5cLysine methyltransferase 5C. (519 aa)
zgc:66440Zgc:66440. (384 aa)
rif1Replication timing regulatory factor 1. (2392 aa)
si:dkey-3h3.3Si:dkey-3h3.3. (441 aa)
mrnipMRN complex-interacting protein; Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair; Belongs to the MRNIP family. (392 aa)
ercc6Excision repair cross-complementation group 6. (1389 aa)
E7FGN5_DANRESi:ch211-161c3.6. (111 aa)
X1WFS5_DANRESi:dkey-40c23.1. (542 aa)
X1WG91_DANRESi:dkey-40c23.2. (967 aa)
E7FBV5_DANRESi:ch73-78o10.1. (178 aa)
pnkpPolynucleotide kinase 3'-phosphatase. (588 aa)
ENSDARP00000135458Si:dkey-40c23.2. (770 aa)
AunipSi:ch1073-228h2.2. (259 aa)
smchd1Structural maintenance of chromosomes flexible hinge domain-containing 1. (1983 aa)
LOC100535417Lyase_1 domain-containing protein. (334 aa)
sirt7Sirtuin 7. (405 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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