STRINGSTRING
tnni1a tnni1a actn3b actn3b myl1 myl1 actn3a actn3a mmp2 mmp2 pdlim3a pdlim3a mybpc1 mybpc1 trim101 trim101 casq1b casq1b parvb parvb robo2 robo2 trim13 trim13 fhl5 fhl5 pdlim3b pdlim3b cabp1a cabp1a nkx2.5 nkx2.5 chordc1b chordc1b tmod2 tmod2 hsp90aa1.1 hsp90aa1.1 lims2 lims2 mylpfb mylpfb tnni2b.1 tnni2b.1 unc45b unc45b tnnc1a tnnc1a hsp90aa1.2 hsp90aa1.2 smyd1a smyd1a tcap tcap igfn1.1 igfn1.1 zgc:109913 zgc:109913 kctd6b kctd6b trim63a trim63a tpm4a tpm4a lims1 lims1 mtmr1b mtmr1b tnni2a.4 tnni2a.4 myl7 myl7 sphkap sphkap chordc1a chordc1a smtnl smtnl atp2a1 atp2a1 tnnt2c tnnt2c lrrc30a lrrc30a capza1a capza1a pdlim1 pdlim1 trim55a trim55a zgc:92429 zgc:92429 cmlc1 cmlc1 myoz2a myoz2a gatad1 gatad1 sync sync tnnc1b tnnc1b trim59 trim59 bag3 bag3 adprhl1 adprhl1 trim54 trim54 fhl2a fhl2a tnni1c tnni1c obscna obscna smpx smpx lrrc10 lrrc10 lmod2a lmod2a fbxl22 fbxl22 ppp1r12c ppp1r12c ankrd2 ankrd2 mylpfa mylpfa LOC101887017 LOC101887017 ldb3a ldb3a F1QQL4_DANRE F1QQL4_DANRE ilk ilk trim55b trim55b desma desma cmya5 cmya5 ahnak ahnak lmod3 lmod3 robo1 robo1 tnnt3a tnnt3a tnnc2 tnnc2 lrrc39 lrrc39 fhl1a fhl1a myoz3a myoz3a ankrd1a ankrd1a PRRC2B PRRC2B myot myot E7FH26_DANRE E7FH26_DANRE synpo2la synpo2la igdcc3 igdcc3 myzap myzap tmod1 tmod1 eva1c eva1c lmod1b lmod1b adprh adprh mtmr10 mtmr10 trim63b trim63b fhl2b fhl2b tmod4 tmod4 spegb spegb svilb svilb actn2b actn2b myl2b myl2b E9QFE7_DANRE E9QFE7_DANRE lmod2b lmod2b neb neb tnni2b.2 tnni2b.2 asb2a.1 asb2a.1 ppp1r12a ppp1r12a tnnt2d tnnt2d obsl1b obsl1b fhl3a fhl3a tnnt3b tnnt3b obsl1a obsl1a actn1 actn1 myoz2b myoz2b tnni1b tnni1b arhgef25b arhgef25b nexn nexn mtmr1a mtmr1a tnnt2a tnnt2a mtm1 mtm1 hrc hrc asb2a.2 asb2a.2 synpo2lb synpo2lb X1WCK8_DANRE X1WCK8_DANRE igfn1.2 igfn1.2 svilc svilc E7FD23_DANRE E7FD23_DANRE ncam3 ncam3 igfn1.4 igfn1.4 igfn1.3 igfn1.3 tnnt2b tnnt2b smyd1b smyd1b ENSDARP00000130602 ENSDARP00000130602 tnni2a.1 tnni2a.1 LOC108190739 LOC108190739 ARHGEF25 ARHGEF25 myom2a myom2a pyroxd1 pyroxd1 tpm2 tpm2 myom1b myom1b myl2a myl2a tnnt2e tnnt2e casq1a casq1a ggps1 ggps1 myl10 myl10 pdlim5a pdlim5a trim32 trim32 sorbs1 sorbs1 pdlim5b pdlim5b zgc:165653 zgc:165653 csrp3 csrp3 spega spega cabp2a cabp2a ENSDARP00000139934 ENSDARP00000139934 LOC100534875 LOC100534875 obscnb obscnb kbtbd13 kbtbd13 cbfb cbfb ccdc102a ccdc102a frg1 frg1 tnni4b.1 tnni4b.1 tnnt1 tnnt1 tnni4b.2 tnni4b.2 tnni4a tnni4a Zmp:0000001167 Zmp:0000001167 ky ky cabp1b cabp1b robo2-2 robo2-2 ENSDARP00000148746 ENSDARP00000148746 svila svila actn4 actn4 tnni1d tnni1d ldb3b ldb3b svild svild myl4 myl4 LOC795051 LOC795051 ENSDARP00000153449 ENSDARP00000153449 ENSDARP00000154801 ENSDARP00000154801 prx prx myl13 myl13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tnni1aTroponin I type 1a (skeletal, slow). (181 aa)
actn3bActinin alpha 3b. (898 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
actn3aActinin alpha 3a. (896 aa)
mmp2Matrix metalloproteinase 2. (657 aa)
pdlim3aPDZ and LIM domain 3a. (307 aa)
mybpc1Myosin-binding protein C1. (1167 aa)
trim101Tripartite motif-containing 101. (429 aa)
casq1bCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (454 aa)
parvbParvin, beta. (365 aa)
robo2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (1387 aa)
trim13Tripartite motif-containing 13; E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins (By similarity). (414 aa)
fhl5Four and a half LIM domains 5. (280 aa)
pdlim3bPDZ and LIM domain 3b. (315 aa)
cabp1aCalcium-binding protein 1a. (186 aa)
nkx2.5NK2 homeobox 5. (314 aa)
chordc1bCysteine and histidine-rich domain-containing protein 1; Regulates centrosome duplication. (341 aa)
tmod2Tropomodulin 2. (344 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
lims2LIM domain-containing protein. (377 aa)
mylpfbMyosin light chain, phosphorylatable, fast skeletal muscle b. (170 aa)
tnni2b.1Troponin I type 2b (skeletal, fast), tandem duplicate 1. (176 aa)
unc45bProtein unc-45 homolog B; Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain (By similarity). Plays a role in sarcomere formation during muscle cell development. Required for myoseptal integrity, myofiber attachment, motility and craniofacial development. Is necessary for normal early lens development. (934 aa)
tnnc1aTroponin C type 1a (slow). (161 aa)
hsp90aa1.2Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2. (734 aa)
smyd1aSET and MYND domain-containing 1a. (465 aa)
tcapTitin-cap (telethonin). (179 aa)
igfn1.1Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 1. (534 aa)
zgc:109913Regulator of G-protein signaling 9-binding protein; Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and/or RGS11). (245 aa)
kctd6bBTB/POZ domain-containing protein KCTD6; Probable substrate-specific adapter of a cullin-containing E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. (237 aa)
trim63aTripartite motif-containing 63a. (345 aa)
tpm4aTropomyosin 4a; Belongs to the tropomyosin family. (284 aa)
lims1LIM domain-containing protein. (336 aa)
mtmr1bMyotubularin-related protein 1b. (649 aa)
tnni2a.4Troponin I type 2a (skeletal, fast), tandem duplicate 4. (176 aa)
myl7Myosin, light polypeptide 7, regulatory. (172 aa)
sphkapA-kinase anchor protein SPHKAP; Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). (1596 aa)
chordc1aCysteine and histidine-rich domain (CHORD)-containing 1a. (339 aa)
smtnlSmoothelin,-like. (493 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
lrrc30aLeucine-rich repeat-containing 30a. (161 aa)
capza1aF-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
pdlim1PDZ and LIM domain 1 (elfin). (322 aa)
trim55aTripartite motif-containing 55a. (443 aa)
zgc:92429Zgc:92429. (387 aa)
cmlc1Cardiac myosin light chain-1. (196 aa)
myoz2aMyozenin 2a. (264 aa)
gatad1GATA zinc finger domain-containing protein 1; Component of some chromatin complex recruited to chromatin sites methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). (242 aa)
syncSyncoilin, intermediate filament protein. (451 aa)
tnnc1bTroponin C type 1b (slow). (161 aa)
trim59Tripartite motif-containing 59. (432 aa)
bag3BCL2-associated athanogene 3. (480 aa)
adprhl1[Protein ADP-ribosylarginine] hydrolase-like protein 1; Belongs to the ADP-ribosylglycohydrolase family. (350 aa)
trim54Tripartite motif-containing 54. (359 aa)
fhl2aFour and a half LIM domains 2a. (279 aa)
tnni1cTroponin I, skeletal, slow c. (199 aa)
obscnaObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF a. (1992 aa)
smpxSmall muscle protein, X-linked. (83 aa)
lrrc10Leucine-rich repeat-containing 10. (269 aa)
lmod2aLeiomodin 2 (cardiac) a. (324 aa)
fbxl22F-box and leucine-rich repeat protein 22. (227 aa)
ppp1r12cProtein phosphatase 1, regulatory subunit 12C. (672 aa)
ankrd2Ankyrin repeat domain 2 (stretch-responsive muscle). (296 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
LOC101887017Leiomodin 1a (smooth muscle). (645 aa)
ldb3aCypher/ZASP splice variant 1 gamma. (596 aa)
F1QQL4_DANRESi:ch211-125o16.4. (1594 aa)
ilkIntegrin-linked kinase. (452 aa)
trim55bTripartite motif-containing 55b. (366 aa)
desmaDesmin a; Belongs to the intermediate filament family. (488 aa)
cmya5Cardiomyopathy associated 5 like. (1759 aa)
ahnakAHNAK nucleoprotein. (6417 aa)
lmod3Leiomodin-3; Essential for the organization of sarcomeric thin filaments in skeletal muscle; Belongs to the tropomodulin family. (670 aa)
robo1Roundabout, axon guidance receptor, homolog 1 (Drosophila). (1687 aa)
tnnt3aTroponin T type 3a (skeletal, fast). (230 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
lrrc39Leucine-rich repeat-containing protein 39; Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress (By similarity). May regulate expression of other M-band proteins via an SRF-dependent pathway (By similarity). Important for normal contractile function in heart. (343 aa)
fhl1aFour and a half LIM domains 1a. (297 aa)
myoz3aMyozenin 3a. (249 aa)
ankrd1aAnkyrin repeat domain 1a (cardiac muscle). (317 aa)
PRRC2BProline rich coiled-coil 2B. (2096 aa)
myotMyotilin. (561 aa)
E7FH26_DANRESi:ch211-57n23.4. (722 aa)
synpo2laSynaptopodin 2-like a. (1179 aa)
igdcc3Immunoglobulin superfamily, DCC subclass, member 3. (773 aa)
myzapMyocardial zonula adherens protein. (584 aa)
tmod1Tropomodulin 1. (356 aa)
eva1cEva-1 homolog C (C. elegans). (438 aa)
lmod1bLeiomodin 1b (smooth muscle). (671 aa)
adprhADP-ribosylarginine hydrolase. (353 aa)
mtmr10Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. (765 aa)
trim63bTripartite motif-containing 63b. (348 aa)
fhl2bFour and a half LIM domains 2b. (279 aa)
tmod4Tropomodulin 4 (Muscle). (343 aa)
spegbStriated muscle-enriched protein kinase b. (3061 aa)
svilbSupervillin b. (179 aa)
actn2bActinin, alpha 2b. (894 aa)
myl2bMyosin, light polypeptide 2, regulatory, cardiac, slow. (168 aa)
E9QFE7_DANRESi:rp71-17i16.4. (161 aa)
lmod2bLeiomodin 2 (cardiac) b. (604 aa)
nebNebulin. (6177 aa)
tnni2b.2Troponin I type 2b (skeletal, fast), tandem duplicate 2. (176 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
tnnt2dTroponin T2d, cardiac. (241 aa)
obsl1bObscurin-like cytoskeletal adaptor 1b. (3304 aa)
fhl3aFour and a half LIM domains 3a. (279 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
obsl1aObscurin-like cytoskeletal adaptor 1a. (2006 aa)
actn1Actinin, alpha 1. (902 aa)
myoz2bMyozenin 2b. (226 aa)
tnni1bTroponin I type 1b (skeletal, slow). (182 aa)
arhgef25bRho guanine nucleotide exchange factor (GEF) 25b. (625 aa)
nexnNexilin (F actin-binding protein). (861 aa)
mtmr1aMyotubularin-related protein 1a. (683 aa)
tnnt2aTroponin T type 2a (cardiac). (282 aa)
mtm1Myotubularin 1. (639 aa)
hrcHistidine-rich calcium-binding protein. (380 aa)
asb2a.2Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa)
synpo2lbSynaptopodin 2-like b. (1184 aa)
X1WCK8_DANRESi:ch211-253p14.2. (451 aa)
igfn1.2Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 2. (1409 aa)
svilcSupervillin c. (1531 aa)
E7FD23_DANRESi:dkey-276j7.1. (220 aa)
ncam3Neural cell adhesion molecule 3. (687 aa)
igfn1.4Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 4. (1230 aa)
igfn1.3Immunoglobulin-like and fibronectin type III domain-containing 1, tandem duplicate 3. (1355 aa)
tnnt2bTroponin T type 2b (cardiac). (233 aa)
smyd1bSET and MYND domain-containing 1b. (486 aa)
ENSDARP00000130602Si:ch1073-398f15.1. (647 aa)
tnni2a.1Troponin I type 2a (skeletal, fast), tandem duplicate 1. (178 aa)
LOC108190739Myozenin-2-like. (122 aa)
ARHGEF25Uncharacterized protein. (538 aa)
myom2aMyomesin 2a. (1366 aa)
pyroxd1Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; Probable FAD-dependent oxidoreductase; involved in the cellular oxidative stress response (By similarity). Required for normal sarcomere structure and muscle fiber integrity. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily. (485 aa)
tpm2Tropomyosin 2 (beta); Belongs to the tropomyosin family. (284 aa)
myom1bMyomesin 1b. (1632 aa)
myl2aMyosin, light chain 2a, regulatory, cardiac, slow. (169 aa)
tnnt2eNovel slow skeletal troponin T family protein. (285 aa)
casq1aCalsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (553 aa)
ggps1Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (350 aa)
myl10Myosin, light chain 10, regulatory. (167 aa)
pdlim5aPDZ and LIM domain 5a. (551 aa)
trim32Tripartite motif-containing 32. (663 aa)
sorbs1Sorbin and SH3 domain-containing 1. (766 aa)
pdlim5bPDZ and LIM domain 5b. (628 aa)
zgc:165653Zgc:165653 protein. (151 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
spegaStriated muscle preferentially expressed protein kinase. (2995 aa)
cabp2aCalcium-binding protein 2a. (236 aa)
ENSDARP00000139934Si:ch211-69b7.6. (1218 aa)
LOC100534875Uncharacterized protein. (307 aa)
obscnbObscurin, cytoskeletal calmodulin and titin-interacting RhoGEF b. (1660 aa)
kbtbd13Kelch repeat and BTB (POZ) domain-containing 13. (473 aa)
cbfbCore-binding factor subunit beta. (201 aa)
ccdc102aCoiled-coil domain-containing protein 102A. (581 aa)
frg1FSHD region gene 1. (255 aa)
tnni4b.1Troponin I4b, tandem duplicate 1. (181 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
tnni4b.2Troponin I4b, tandem duplicate 2. (218 aa)
tnni4aTroponin I4a. (183 aa)
Zmp:0000001167ANK_REP_REGION domain-containing protein. (136 aa)
kyKyphoscoliosis peptidase. (623 aa)
cabp1bCalcium-binding protein 1b. (167 aa)
robo2-2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (136 aa)
ENSDARP00000148746Uncharacterized protein. (1093 aa)
svilaSupervillin a. (1763 aa)
actn4Actinin, alpha 4. (923 aa)
tnni1dTroponin I, skeletal, slow d. (198 aa)
ldb3bLIM domain-binding 3b. (292 aa)
svildSupervillin d. (1468 aa)
myl4Myosin, light chain 4, alkali; atrial, embryonic. (187 aa)
LOC795051PDZ domain-containing protein. (3647 aa)
ENSDARP00000153449HP domain-containing protein. (82 aa)
ENSDARP00000154801PRKG1_interact domain-containing protein. (144 aa)
prxPeriaxin. (4197 aa)
myl13Atrial myosin light chain. (186 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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