STRINGSTRING
ptpn3 ptpn3 myo10 myo10 farp1 farp1 ezra ezra frmd8 frmd8 ptpn21 ptpn21 epb41l3a epb41l3a krit1 krit1 mylipa mylipa msna msna nf2b nf2b jak1 jak1 epb41b epb41b jak3 jak3 ptk2bb ptk2bb epb41l4a epb41l4a plekhh1 plekhh1 mylipb mylipb ezrb ezrb FRMD1 FRMD1 frmpd3 frmpd3 FRMD5 FRMD5 frmd5 frmd5 msnb msnb frmpd1b frmpd1b ptpn4b ptpn4b tln2a tln2a jak2a jak2a farp2 farp2 ptk2ba ptk2ba PLEKHH3 PLEKHH3 myo10l1 myo10l1 tyk2 tyk2 nf2a nf2a FRMD4A FRMD4A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ptpn3Protein tyrosine phosphatase non-receptor type 3. (839 aa)
myo10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2069 aa)
farp1FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived). (1025 aa)
ezraEzrl protein. (595 aa)
frmd8FERM domain-containing protein 8; Promotes the cell surface stability of rhomboid 5 homologs and prevents their degradation via the endolysosomal pathway. By acting on rhomboid 5 homologs, involved in ADAM17-mediated ligand shedding (By similarity). Negatively regulates the Wnt/beta-catenin signaling pathway. (471 aa)
ptpn21Protein tyrosine phosphatase non-receptor type 21. (1204 aa)
epb41l3aErythrocyte membrane protein band 4.1-like 3a. (826 aa)
krit1Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa)
mylipaE3 ubiquitin-protein ligase MYLIP-A; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC) (By similarity). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway. (472 aa)
msnaMoesin a. (579 aa)
nf2bNeurofibromin 2b (merlin). (586 aa)
jak1Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa)
epb41bErythrocyte membrane protein band 4.1 (Elliptocytosis 1, RH-linked). (1534 aa)
jak3Tyrosine-protein kinase. (1103 aa)
ptk2bbProtein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa)
epb41l4aBand 4.1-like protein 4; Not known, binds calmodulin. (671 aa)
plekhh1Pleckstrin homology domain-containing family H member 1; Critical component of the guidance pathway underlying endothelial cell migration and blood vessel patterning. Involved in mediating membrane localization of ephrin proteins, which have been shown to provide guidance cues for endothelial cell migration. (1432 aa)
mylipbE3 ubiquitin-protein ligase MYLIP-B; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC). Regulates cell movements during gastrulation by acting downstream of fz7 to antagonize the frizzled-signaling pathway (By similarity). (464 aa)
ezrbEzrin b. (583 aa)
FRMD1Zgc:172136 protein. (552 aa)
frmpd3FERM and PDZ domain-containing 3. (1696 aa)
FRMD5Si:ch211-69m14.1. (576 aa)
frmd5FERM domain-containing 5. (571 aa)
msnbMoesin b. (577 aa)
frmpd1bFERM and PDZ domain-containing 1b. (1656 aa)
ptpn4bTyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (930 aa)
tln2aTalin 2a. (2543 aa)
jak2aTyrosine-protein kinase. (1095 aa)
farp2FERM, RhoGEF and pleckstrin domain protein 2. (1044 aa)
ptk2baProtein tyrosine kinase 2 beta, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (933 aa)
PLEKHH3Si:ch211-18i17.2. (761 aa)
myo10l1Myosin X,-like 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2041 aa)
tyk2Tyrosine-protein kinase. (1165 aa)
nf2aSimilar to neurofibromin 2. (593 aa)
FRMD4ASi:ch211-220f12.1. (1003 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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