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| | flt1 | Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa) |
| | epha4l | Eph receptor A4,-like. (988 aa) |
| | acvr1l | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (506 aa) |
| | syk | Tyrosine-protein kinase. (608 aa) |
| | MAP3K13 | Mitogen-activated protein kinase kinase kinase. (982 aa) |
| | yes1 | Tyrosine-protein kinase yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak. (546 aa) |
| | fgfr3 | Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (819 aa) |
| | fgfr1a | Fibroblast growth factor receptor 1-A; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and normal skeletogenesis. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol-1,4,5-trisphosphate. Phosphorylation of FRS2 triggers [...] (809 aa) |
| | bmpr1aa | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa) |
| | ntrk1 | Tyrosine-protein kinase receptor. (797 aa) |
| | limk1b | LIM domain kinase 1b. (615 aa) |
| | gucy2g | Guanylate cyclase. (1127 aa) |
| | fynb | Tyrosine-protein kinase fynb; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in CNTN1-mediated signaling (By similarity). (544 aa) |
| | jak1 | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type. Appears to be required in early development for specific cell migrations (epiboly), expression of homeobox protein goosecoid and formation of anterior structures. (1153 aa) |
| | ephb3a | Ephrin type-B receptor 3; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development. In addition to its role in axon guidance plays also an important re [...] (925 aa) |
| | lyn | Tyrosine-protein kinase. (510 aa) |
| | abl2 | Tyrosine-protein kinase. (1135 aa) |
| | ephb2b | Eph receptor B2b. (989 aa) |
| | kitb | Mast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (957 aa) |
| | epha2b | Eph receptor A2 b. (979 aa) |
| | braf | B-Raf proto-oncogene, serine/threonine kinase. (817 aa) |
| | kdr | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa) |
| | jak3 | Tyrosine-protein kinase. (1103 aa) |
| | tek | Tyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa) |
| | ptk2bb | Protein tyrosine kinase 2 beta, b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1004 aa) |
| | E7F063_DANRE | Tyrosine-protein kinase. (480 aa) |
| | ltk | Tyrosine-protein kinase receptor. (1530 aa) |
| | ret | Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1106 aa) |
| | ryk | Receptor-like tyrosine kinase. (604 aa) |
| | ankk1 | Ankyrin repeat and kinase domain-containing 1. (733 aa) |
| | ilk | Integrin-linked kinase. (452 aa) |
| | nek7 | Novel protein similar to vertebrate NIMA (Never in mitosis gene a)-related kinase 7 (NEK7); Belongs to the protein kinase superfamily. (297 aa) |
| | epha5 | Uncharacterized protein. (983 aa) |
| | flt3 | Fms-related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (956 aa) |
| | raf1b | Raf-1 proto-oncogene, serine/threonine kinase b. (629 aa) |
| | ptk6b | Tyrosine-protein kinase. (511 aa) |
| | tesk2 | Testis-associated actin remodelling kinase 2. (634 aa) |
| | map3k10 | Mitogen-activated protein kinase kinase kinase. (1062 aa) |
| | limk2 | LIM domain kinase 2. (651 aa) |
| | ephb4b | Ephrin type-B receptor 4b; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (976 aa) |
| | csk | Tyrosine-protein kinase. (450 aa) |
| | epha7 | Eph receptor A7. (1016 aa) |
| | src | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (534 aa) |
| | pdgfra | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for pdgfa, pdgfb and pdgfc and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound [...] (1456 aa) |
| | styk1a | Serine/threonine/tyrosine kinase 1a. (435 aa) |
| | ek1 | Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (981 aa) |
| | insrb | Tyrosine-protein kinase receptor. (1348 aa) |
| | lmtk2 | Lemur tyrosine kinase 2. (1446 aa) |
| | kita | Mast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa) |
| | ror2 | Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (939 aa) |
| | mertka | C-mer proto-oncogene tyrosine kinase a. (952 aa) |
| | nrbp2b | Nuclear receptor-binding protein 2b. (504 aa) |
| | gucy2f | Guanylate cyclase. (1107 aa) |
| | pomk | Protein O-mannose kinase; Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)- beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4- (phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (dag1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only [...] (347 aa) |
| | tnni3k | TNNI3-interacting kinase. (835 aa) |
| | styk1b | Serine/threonine/tyrosine kinase 1b. (447 aa) |
| | E7FGQ0_DANRE | Si:ch73-206d17.1. (393 aa) |
| | hck | Tyrosine-protein kinase. (499 aa) |
| | TESK1 | Si:ch211-113e8.3. (657 aa) |
| | tyro3 | Tyrosine-protein kinase receptor TYRO3; May be involved in cell adhesion processes, particularly in the central nervous system; Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily. (868 aa) |
| | si:dkey-40m6.8 | Si:dkey-40m6.8. (2769 aa) |
| | npr1a | Guanylate cyclase. (1067 aa) |
| | ror1 | Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (950 aa) |
| | tnk1 | Tyrosine kinase, non-receptor, 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (733 aa) |
| | araf | A-Raf proto-oncogene, serine/threonine kinase. (604 aa) |
| | epha6 | Eph receptor A6. (1001 aa) |
| | mst1ra | Macrophage-stimulating 1 receptor a. (1350 aa) |
| | fyna | Tyrosine-protein kinase fyna; Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Role in cntn1-mediated signaling (By similarity). Required for convergent extension cell movements during gastrulation, acting with yes via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. (537 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | epha4a | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa) |
| | alk | Tyrosine-protein kinase receptor. (1181 aa) |
| | tyk2 | Tyrosine-protein kinase. (1165 aa) |
| | fes | Tyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (826 aa) |
| | btk | Tyrosine-protein kinase. (640 aa) |
| | fgfr2 | Fibroblast growth factor receptor 2; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in kerati [...] (838 aa) |
| | abl1 | Tyrosine-protein kinase. (1081 aa) |
| | ptk2ba | Protein tyrosine kinase 2 beta, a; Belongs to the protein kinase superfamily. Tyr protein kinase family. (933 aa) |
| | U3JAG6_DANRE | Guanylate cyclase. (1071 aa) |
| | SRMS | Tyrosine-protein kinase. (492 aa) |
| | map3k12 | Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (856 aa) |
| | lck | Tyrosine-protein kinase. (503 aa) |
| | jak2a | Tyrosine-protein kinase. (1095 aa) |
| | tnk2b | Tyrosine kinase, non-receptor, 2b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1078 aa) |
| | ksr2 | Kinase suppressor of ras 2. (962 aa) |
| | flt4 | Vascular endothelial growth factor receptor 3; Tyrosine-protein kinase that acts as a cell-surface receptor for vegf or vegfc. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels, but not required for proper vasculogenesis or hematopoiesis. (1368 aa) |
| | kdrl | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa) |
| | ddr2a | Discoidin domain receptor tyrosine kinase 2a. (868 aa) |
| | blk | Tyrosine-protein kinase. (485 aa) |
| | bmpr1ba | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (530 aa) |
| | ntrk3b | Tyrosine-protein kinase receptor. (813 aa) |
| | ddr2l | Discoidin domain receptor family, member 2,-like. (873 aa) |
| | aatkb | Apoptosis-associated tyrosine kinase b; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1657 aa) |
| | adgrg1-2 | Adhesion G protein-coupled receptor G1. (513 aa) |
| | gc2 | Guanylate cyclase. (1107 aa) |
| | fgfr4 | Fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down- regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation o [...] (923 aa) |
| | tie1 | Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1150 aa) |
| | csf1ra | Macrophage colony-stimulating factor 1 receptor; Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Promotes reorganization of the ac [...] (977 aa) |
| | zak | Sterile alpha motif and leucine zipper-containing kinase AZK. (789 aa) |
| | E7FEW6_DANRE | Si:dkeyp-75h12.2. (653 aa) |
| | ddr1 | Discoidin domain receptor tyrosine kinase 1. (974 aa) |
| | ephb4a | Ephrin type-B receptor 4a; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 is involved in the regulation of cell adhesion and cell migration, and plays a central role in heart morphogenesis, angiogenesis and [...] (987 aa) |
