STRINGSTRING
six1a six1a lhx4 lhx4 emx1 emx1 rx2 rx2 meox2a meox2a prrx1b prrx1b pou3f3a pou3f3a mnx2a mnx2a gsx2 gsx2 otx1 otx1 zgc:158291 zgc:158291 pou5f3 pou5f3 rx3 rx3 cers6 cers6 hoxb8b hoxb8b hoxb5b hoxb5b lmx1bb lmx1bb six2b six2b six3b six3b six9 six9 eve1 eve1 hoxb13a hoxb13a hoxb7a hoxb7a hoxb3a hoxb3a hoxa9b hoxa9b hoxd10a hoxd10a lhx5 lhx5 six2a six2a arxa arxa cux1a cux1a vax2 vax2 pou1f1 pou1f1 gsc gsc evx2 evx2 hoxd13a hoxd13a hoxd12a hoxd12a hoxd11a hoxd11a hoxd9a hoxd9a hoxd4a hoxd4a tgif1 tgif1 nkx6.3 nkx6.3 nkx1.2la nkx1.2la meox2b meox2b satb2 satb2 adnpa adnpa pou3f2b pou3f2b LHX3 LHX3 bsx bsx hoxc6b hoxc6b cers2b cers2b hoxc11b hoxc11b lmx1ba lmx1ba LOC100535338 LOC100535338 nkx2.2a nkx2.2a cdx1b cdx1b pax6b pax6b cdx1a cdx1a en1b en1b tshz1 tshz1 hoxc10a hoxc10a hoxc13b hoxc13b pou2f3 pou2f3 zfhx4 zfhx4 hnf1bb hnf1bb cers3a cers3a evx1 evx1 ved ved nkx6.2 nkx6.2 msx2b msx2b hoxa9a hoxa9a irx3a irx3a uncx uncx pbx1b pbx1b hoxa3a hoxa3a pbx1a pbx1a pax7a pax7a barhl2 barhl2 hhex hhex arxb arxb pbx3b pbx3b hoxa13a hoxa13a pax6a pax6a hoxa1a hoxa1a hoxa5a hoxa5a hoxc12b hoxc12b msx2a msx2a hoxa11a hoxa11a LOC100008066 LOC100008066 nkx2.2b nkx2.2b vent vent phox2bb phox2bb E7EY09_DANRE E7EY09_DANRE hoxc3a hoxc3a meis3 meis3 zgc:113176 zgc:113176 hmx3b hmx3b six4a six4a pax10 pax10 pou4f3 pou4f3 pou3f3b pou3f3b onecutl onecutl alx1 alx1 lhx2b lhx2b pknox2 pknox2 otpb otpb dlx4a dlx4a otpa otpa hoxb1b hoxb1b hoxc5a hoxc5a lhx2a lhx2a hoxd3a hoxd3a pou6f2 pou6f2 barx2 barx2 hnf1ba hnf1ba hoxb2a hoxb2a drgx drgx irx4b irx4b phox2ba phox2ba shox shox sebox sebox alx4a alx4a hopx hopx pou4f2 pou4f2 pknox1.1 pknox1.1 pou6f1 pou6f1 otx2b otx2b six6b six6b pknox1.2 pknox1.2 pax7b pax7b hmx2 hmx2 mixl1 mixl1 hoxc6a hoxc6a nkx3.3 nkx3.3 dmbx1a dmbx1a tshz3a tshz3a hoxc9a hoxc9a adnpb adnpb pou3f2a pou3f2a F1Q7K3_DANRE F1Q7K3_DANRE dlx2a dlx2a hdx hdx nanog nanog hoxb1a hoxb1a dlx5a dlx5a mnx2b mnx2b hoxb10a hoxb10a cdx4 cdx4 tshz2 tshz2 rx1 rx1 dlx4b dlx4b meox1 meox1 gbx1 gbx1 pbx4 pbx4 hmx3a hmx3a vsx1 vsx1 hoxc13a hoxc13a hoxc12a hoxc12a hoxc11a hoxc11a hoxc8a hoxc8a hoxc4a hoxc4a hoxc1a hoxc1a dlx6a dlx6a six7 six7 meis1b meis1b pitx3 pitx3 mxtx1 mxtx1 hoxb6a hoxb6a tlx1 tlx1 hoxb5a hoxb5a nkx2.7 nkx2.7 gbx2 gbx2 zhx3 zhx3 hoxa11b hoxa11b lmx1a lmx1a dlx2b dlx2b cers2a cers2a hoxb4a hoxb4a tlx2 tlx2 hoxb6b hoxb6b hmx4 hmx4 dlx1a dlx1a isl1 isl1 phox2a phox2a otx2a otx2a dbx1b dbx1b lbx1b lbx1b barx1 barx1 msx1b msx1b lhx6 lhx6 pbx2 pbx2 shox2 shox2 pax3b pax3b isl2a isl2a lhx1a lhx1a hoxb9a hoxb9a dlx3b dlx3b hoxa2b hoxa2b en1a en1a dbx1a dbx1a msx3 msx3 lhx1b lhx1b mxtx2 mxtx2 irx7 irx7 onecut1 onecut1 meis1a meis1a dmbx1b dmbx1b pou3f1 pou3f1 six1b six1b en2a en2a lbx2 lbx2 crx crx six6a six6a meis2b meis2b pnx pnx pax3a pax3a vsx2 vsx2 vax1 vax1 prrx1a prrx1a irx5a irx5a lbx1a lbx1a irx6a irx6a hoxb8a hoxb8a hoxa10b hoxa10b barhl1a barhl1a irx4a irx4a gsx1 gsx1 zgc:91944 zgc:91944 mnx1 mnx1 pitx2 pitx2 hoxa13b hoxa13b lhx9 lhx9 nkx3-2 nkx3-2 uncx4.1 uncx4.1 isl2b isl2b en2b en2b nkx2.3 nkx2.3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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six1aHomeobox protein six1a; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells (By similarity). Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles; Belongs to the SIX/Sine oculis homeobox family. (283 aa)
lhx4LIM homeobox 4. (391 aa)
emx1Homeobox protein EMX1; May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system; Belongs to the EMX homeobox family. (231 aa)
rx2Retinal homeobox protein Rx2; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (327 aa)
meox2aMesenchyme homeobox 2a. (302 aa)
prrx1bPaired-related homeobox 1b. (245 aa)
pou3f3aPOU domain, class 3, transcription factor 3-A; Transcription factor that may play important roles in patterning the embryonic brain. (446 aa)
mnx2aMotor neuron and pancreas homeobox 2a. (309 aa)
gsx2GS homeobox 2. (242 aa)
otx1Homeobox protein OTX1 B; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain; Belongs to the paired homeobox family. Bicoid subfamily. (323 aa)
zgc:158291POU domain protein. (343 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
rx3Retinal homeobox protein Rx3; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation. (292 aa)
cers6Ceramide synthase 6. (391 aa)
hoxb8bHomeobox protein Hox-B8b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (247 aa)
hoxb5bHomeobox protein Hox-B5b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (276 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
six2bSimilar to sine oculis homeobox homolog 2.1. (285 aa)
six3bSine oculis homeobox homolog 3b. (293 aa)
six9Si:dkey-149j18.3 protein. (235 aa)
eve1Even-skipped-like1. (224 aa)
hoxb13aHomeobox protein Hox-B13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (303 aa)
hoxb7aHomeobox protein Hox-B7a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (227 aa)
hoxb3aHomeobox protein Hox-B3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (417 aa)
hoxa9bHomeobox protein Hox-A9b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (253 aa)
hoxd10aHomeobox protein Hox-D10a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (332 aa)
lhx5LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon. (399 aa)
six2aSine oculis homeobox homolog 2.1. (288 aa)
arxaAristaless-related homeobox protein; Appears to be indispensable for the central nervous system development. May have a role in the neuronal differentiation of the ganglionic eminence and ventral thalamus. May also be involved in axonal guidance in the floor plate; Belongs to the paired homeobox family. Bicoid subfamily. (453 aa)
cux1aHomeobox protein cut-like. (1495 aa)
vax2Ventral anterior homeobox 2; Transcription factor that may function in dorsoventral specification of the forebrain. Required for closure of the choroid fissure and together with vax1 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (307 aa)
pou1f1POU domain protein. (350 aa)
gscHomeobox protein goosecoid. (240 aa)
evx2Even-skipped homeobox 2. (418 aa)
hoxd13aHomeobox protein Hox-D13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (256 aa)
hoxd12aHomeobox protein Hox-D12a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (277 aa)
hoxd11aHomeobox protein Hox-D11a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (276 aa)
hoxd9aHomeobox protein Hox-D9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (262 aa)
hoxd4aHomeobox protein Hox-D4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (256 aa)
tgif1TGFB-induced factor homeobox 1. (273 aa)
nkx6.3NK6 homeobox 3. (272 aa)
nkx1.2laNK1 transcription factor-related 2-like,a. (270 aa)
meox2bMesenchyme homeobox 2b. (289 aa)
satb2DNA-binding protein SATB. (834 aa)
adnpaActivity-dependent neuroprotector homeobox a. (969 aa)
pou3f2bPOU domain, class 3, transcription factor 2; Transcription factor that may play important roles in patterning the embryonic brain; Belongs to the POU transcription factor family. Class-3 subfamily. (378 aa)
LHX3LIM/homeobox protein Lhx3. (398 aa)
bsxBrain-specific homeobox protein homolog; DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain; Belongs to the distal-less homeobox family. (227 aa)
hoxc6bHomeobox protein Hox-C6b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (228 aa)
cers2bCeramide synthase 2b. (383 aa)
hoxc11bHomeobox C11b. (306 aa)
lmx1baLIM homeobox transcription factor 1, beta a. (375 aa)
LOC100535338Homeobox domain-containing protein. (377 aa)
nkx2.2aHomeobox protein Nkx-2.2a; Transcriptional activator involved in the development of insulin-producting beta cells in the endocrine pancreas (By similarity). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (By similarity). (273 aa)
cdx1bCaudal type homeodomain protein. (255 aa)
pax6bPaired box 6b. (450 aa)
cdx1aHomeodomain protein Cdx1a. (228 aa)
en1bHomeobox protein engrailed-like. (274 aa)
tshz1Teashirt homolog 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Belongs to the teashirt C2H2-type zinc-finger protein family. (1158 aa)
hoxc10aHomeobox C10a. (337 aa)
hoxc13bHomeobox protein Hox-C13b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). Plays a role in early embryonic development; Belongs to the Abd-B homeobox family. (273 aa)
pou2f3POU domain protein. (398 aa)
zfhx4Zinc finger homeobox 4. (3528 aa)
hnf1bbHepatocyte nuclear factor 1-beta-B; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Acts downstream of hnf1ba but is not required for induction of rhombomere r5/r6 gene expression in the hindbrain. (532 aa)
cers3aCeramide synthase 3a. (380 aa)
evx1Even-skipped homeobox 1. (377 aa)
vedVentrally-expressed dharma/bozozok antagonist. (278 aa)
nkx6.2NK6 homeobox 2. (278 aa)
msx2bHomeobox protein MSH-D; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (241 aa)
hoxa9aHomeobox protein Hox-A9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (250 aa)
irx3aIroquois 3 homeobox protein. (454 aa)
uncxHomeobox protein unc-4 homolog. (483 aa)
pbx1bPre-B-cell leukemia homeobox 1b. (429 aa)
hoxa3aHomeobox protein Hox-A3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (410 aa)
pbx1aPre-B-cell leukemia transcription factor 1a. (428 aa)
pax7aTranscription factor PAX7C. (507 aa)
barhl2BarH-class homeodomain transcription factor. (364 aa)
hhexHematopoietically-expressed homeobox protein hhex; Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. Regulates the differentiation of both endothelial and blood cells. Plays a role in embryonic dorsoventral patterning by regulating bmp expression. May establish anterior identity. Functions in the embryo to regulate liver development. Functions extraembryonically to generate organ chirality. (177 aa)
arxbAristaless-related homeobox b. (385 aa)
pbx3bPre-B-cell leukemia transcription factor 3b. (386 aa)
hoxa13aHomeobox protein Hox-A13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (310 aa)
pax6aPaired box protein Pax-6; Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development; Belongs to the paired homeobox family. (451 aa)
hoxa1aHomeobox protein Hox-A1a; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis (By similarity). (329 aa)
hoxa5aHomeobox protein Hox-A5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (265 aa)
hoxc12bHomeobox protein Hox-C12b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (283 aa)
msx2aHomeobox protein MSH-A; Probable morphogenetic role; Belongs to the Msh homeobox family. (257 aa)
hoxa11aHomeobox protein Hox-A11a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (284 aa)
LOC100008066Homeobox domain-containing protein. (251 aa)
nkx2.2bNK2 transcription factor related 2b. (237 aa)
ventVentral-expressed homeobox. (170 aa)
phox2bbPaired-like homeobox 2Bb. (284 aa)
E7EY09_DANRESi:ch211-232b12.5. (981 aa)
hoxc3aHomeobox protein Hox-C3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family. (257 aa)
meis3Myeloid ecotropic viral integration site 3. (415 aa)
zgc:113176Zgc:113176. (407 aa)
hmx3bH6 family homeobox 3b. (196 aa)
six4aSine oculis homeobox homolog 4.2. (593 aa)
pax10Paired box 10. (275 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
pou3f3bPOU domain, class 3, transcription factor 3-B; Transcription factor that may play important roles in patterning the embryonic brain. (443 aa)
onecutlOne cut domain family member. (450 aa)
alx1ALX homeobox protein 1; Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes. Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Required for proper neural crest cell migration into the frontonasal primordia during development ; Belongs to the paired homeobox family. (320 aa)
lhx2bLIM homeobox 2b. (427 aa)
pknox2TALE homeodomain transcription factor Prep2. (474 aa)
otpbHomeobox protein orthopedia B; Involved in the specification of isotocin cells. Required for the specification of dopaminergic neurons in the developing hypothalamus and posterior tuberculum; Belongs to the paired homeobox family. Bicoid subfamily. (328 aa)
dlx4aHomeobox protein Dlx4a. (250 aa)
otpaOrthopedia homeobox a. (332 aa)
hoxb1bHomeobox protein Hox-B1b; Sequence-specific transcription factor. Part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments; Belongs to the Antp homeobox family. Labial subfamily. (229 aa)
hoxc5aHomeobox protein Hox-C5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (213 aa)
lhx2aLIM homeobox 2a. (328 aa)
hoxd3aHomeobox protein Hox-D3a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (396 aa)
pou6f2POU domain protein. (694 aa)
barx2BARX homeobox 2. (268 aa)
hnf1baHepatocyte nuclear factor 1-beta-A; Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (By similarity). Required for induction of rhombomere r5/r6 gene expression in the hindbrain. (555 aa)
hoxb2aHomeobox protein Hox-B2a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Plays an important role in the patterning of hindbrain and pharyngeal arches. (409 aa)
drgxDorsal root ganglia homeobox. (287 aa)
irx4bIroquois homeobox 4b. (439 aa)
phox2baPaired-like homeobox 2Ba. (155 aa)
shoxShort stature homeobox. (285 aa)
seboxHomeobox protein SEBOX; Probable transcription factor involved in the control of specification of mesoderm and endoderm. Acts in parallel with bonnie and clyde, faust and casanova in the Nodal signaling pathway. (313 aa)
alx4aALX homeobox 4a. (368 aa)
hopxHomeodomain-only protein; Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. May act via an interaction with SRF, leading to modulate the expression of SRF- dependent cardiac-specific genes and cardiac development. May act as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assist in chaperone-mediated protein refolding (By similarity). (77 aa)
pou4f2POU domain protein. (384 aa)
pknox1.1Homeodomain transcription factor Prep1. (433 aa)
pou6f1POU domain, class 6, transcription factor 1; Transcription factor that binds with high affinity to the motif 5'-TAATGARAT-3'. (610 aa)
otx2bHomeobox protein OTX2; May play a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. (289 aa)
six6bSine oculis-related homeobox 6b. (245 aa)
pknox1.2Pbx/knotted 1 homeobox 1.2. (445 aa)
pax7bPaired box protein 7b. (510 aa)
hmx2H6 family homeobox 2. (269 aa)
mixl1Mix paired-like homeobox. (327 aa)
hoxc6aHomeobox protein Hox-C6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (208 aa)
nkx3.3NK3 homeobox 3. (240 aa)
dmbx1aDiencephalon/mesencephalon homeobox protein 1-A; Required for eye and tectum development. May act as a transcriptional repressor. (383 aa)
tshz3aTeashirt zinc finger homeobox 3a. (1021 aa)
hoxc9aHomeobox protein Hox-C9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (270 aa)
adnpbActivity-dependent neuroprotector homeobox b. (1003 aa)
pou3f2aPOU domain protein. (337 aa)
F1Q7K3_DANRESi:ch73-386h18.1. (3356 aa)
dlx2aHomeobox protein Dlx2a; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (274 aa)
hdxHighly divergent homeobox. (676 aa)
nanogOvary-expressed homeobox protein. (384 aa)
hoxb1aHomeobox protein Hox-B1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (316 aa)
dlx5aHomeobox protein Dlx5a; Belongs to the distal-less homeobox family. (282 aa)
mnx2bMotor neuron and pancreas homeobox 2b. (328 aa)
hoxb10aHomeobox protein Hox-B10a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (214 aa)
cdx4Caudal type homeo box transcription factor 4. (270 aa)
tshz2Teashirt zinc finger homeobox 2. (1020 aa)
rx1Retinal homeobox protein Rx1; Plays a critical role in eye formation by regulating the initial specification of retinal cells and/or their subsequent proliferation; Belongs to the paired homeobox family. Bicoid subfamily. (330 aa)
dlx4bHomeobox protein Dlx4b; During larvae development, may be important for neurocranium morphogenesis. (254 aa)
meox1Homeobox protein MOX-1; Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. Binds specifically to the promoter of target genes and regulates their expression. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. Acts by med [...] (253 aa)
gbx1Gastrulation brain homeobox 1. (316 aa)
pbx4Pre-B-cell leukemia transcription factor 4. (343 aa)
hmx3aHomeobox protein HMX3; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence (By similarity). Belongs to the HMX homeobox family. (297 aa)
vsx1Visual system homeobox 1; May be involved in maintenance as well as cellular differentiation of retinal interneurons, such as bipolar cells. May play a role in establishing interneuronal cell classes in nonsensory as well as sensory systems; Belongs to the paired homeobox family. (340 aa)
hoxc13aHomeobox protein Hox-C13a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (306 aa)
hoxc12aHomeo box C12a. (274 aa)
hoxc11aHomeobox protein Hox-C11a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (306 aa)
hoxc8aHomeobox protein Hox-C8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (250 aa)
hoxc4aHomeobox protein Hox-C4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (268 aa)
hoxc1aHomeobox protein Hox-C1a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (302 aa)
dlx6aHomeobox protein Dlx6a. (247 aa)
six7Sine oculis homeobox homolog 7. (256 aa)
meis1bMyeloid ecotropic viral integration 1. (388 aa)
pitx3Pituitary homeobox 3; Transcriptional regulator which may play a role in the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons (By similarity). Required for lens and retinal development and for pituitary pre-placode formation and cell specification; Belongs to the paired homeobox family. Bicoid subfamily. (293 aa)
mxtx1Mix-type homeobox gene 1. (309 aa)
hoxb6aHomeobox protein Hox-B6a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (228 aa)
tlx1T-cell leukemia, homeobox 1. (301 aa)
hoxb5aHomeobox protein Hox-B5a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (275 aa)
nkx2.7NK2 transcription factor-related 7. (269 aa)
gbx2Gastrulation brain homeo box 2. (342 aa)
zhx3Zinc fingers and homeoboxes 3. (1083 aa)
hoxa11bHomeobox protein Hox-A11b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (283 aa)
lmx1aLIM homeobox transcription factor 1, alpha. (366 aa)
dlx2bHomeobox protein Dlx2b. (276 aa)
cers2aLAG1 homolog, ceramide synthase 2 (S. cerevisiae). (383 aa)
hoxb4aHomeobox protein Hox-B4a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (246 aa)
tlx2T cell leukemia homeobox 2. (301 aa)
hoxb6bHomeobox protein Hox-B6b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (224 aa)
hmx4H6 family homeobox 4. (238 aa)
dlx1aHomeobox protein Dlx1a. (252 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
phox2aPaired-like homeobox 2A. (280 aa)
otx2aHomeobox protein OTX1 A; Plays a role in very early embryogenesis, gastrulation, and the development and subdivision of the diencephalon and the midbrain. Establishes and positions the zona limitans intrathalamica (ZLI) in the diencephalon. May play a role in the organizer function. Probably acts redundantly with otx2 in early brain development. (338 aa)
dbx1bHomeobox protein DBX1-B; Belongs to the H2.0 homeobox family. (322 aa)
lbx1bLadybird homeobox 1b. (265 aa)
barx1Homeobox protein BarH-like 1; Transcription factor, is involved in craniofacial development, and in stomach organogenesis; Belongs to the BAR homeobox family. (248 aa)
msx1bHomeobox protein MSH-B; Probable morphogenetic role; Belongs to the Msh homeobox family. (257 aa)
lhx6LIM homeobox 6. (375 aa)
pbx2Pre-B-cell leukemia homeobox 2. (403 aa)
shox2Short stature homeobox 2. (299 aa)
pax3bPaired box 3b. (469 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
lhx1aLIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa)
hoxb9aHomeobox protein Hox-B9a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (249 aa)
dlx3bHomeobox protein Dlx3b; Involved in the development of the inner ear; Belongs to the distal-less homeobox family. (269 aa)
hoxa2bHomeobox protein Hox-A2b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (363 aa)
en1aHomeobox protein engrailed-1a. (231 aa)
dbx1aHomeobox protein DBX1-A; Belongs to the H2.0 homeobox family. (314 aa)
msx3Homeobox protein MSH-C; Involved in the development of the inner ear; Belongs to the Msh homeobox family. (273 aa)
lhx1bLIM class homeodomain protein. (402 aa)
mxtx2Mix-type homeobox gene 2. (296 aa)
irx7Iroquois homeodomain transcription factor Ziro7. (314 aa)
onecut1One cut domain family member. (461 aa)
meis1aMyeloid ecotropic viral integration site 4.1a. (380 aa)
dmbx1bDiencephalon/mesencephalon homeobox protein 1-B. (369 aa)
pou3f1POU domain, class 3, transcription factor 1; Transcription factor that may play important roles in patterning the embryonic brain. Could directly respond to the reception of the sonic hedgehog (shh) signal; Belongs to the POU transcription factor family. Class-3 subfamily. (368 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
en2aHomeobox protein engrailed-2a. (265 aa)
lbx2Ladybird homeobox homolog 2 (Drosophila). (257 aa)
crxCone-rod homeobox. (281 aa)
six6aSine oculis-related homeobox 6a. (245 aa)
meis2bMyeloid ecotropic viral integration site 2.1. (393 aa)
pnxHomeobox protein pnx; Transcriptional repressor. Activity as a repressor is enhanced by binding to the corepressor tle3a. (182 aa)
pax3aTranscription factor PAX3. (509 aa)
vsx2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Mediates the differentiation of V2a interneurons (By similarity). Plays a role in eye development and organization of the neuroretina. (372 aa)
vax1Ventral anterior homeobox 1; Transcription factor that is required for closure of the choroid fissure and together with Vax2 is required for optic nerve differentiation and to limit retinal development to the optic cup. Belongs to the EMX homeobox family. (317 aa)
prrx1aPaired-related homeobox 1a. (245 aa)
irx5aIroquois homeobox protein 5. (446 aa)
lbx1aNovel protein similar to zebrafish lady bird-like homeobox 1 Drosophila homolog (Lbx1h). (269 aa)
irx6aIroquois homeobox protein 6a. (477 aa)
hoxb8aHomeobox protein Hox-B8a; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (245 aa)
hoxa10bHomeobox protein Hox-A10b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (330 aa)
barhl1aBarH-class homeodomain transcription factor 3. (299 aa)
irx4aIroquois homeobox protein 4a. (440 aa)
gsx1Genetic screen homeobox 1 protein. (243 aa)
zgc:91944Zgc:91944. (469 aa)
mnx1Motor neuron and pancreas homeobox 1. (311 aa)
pitx2Pituitary homeobox 2; Isoform a and isoform c differentially regulate mesendoderm formation and asymmetric organ development. Both isoforms regulate left-right development, but isoform a has a stronger effect on heart laterality; Belongs to the paired homeobox family. Bicoid subfamily. (314 aa)
hoxa13bHomeobox protein Hox-A13b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Abd-B homeobox family. (289 aa)
lhx9LIM/homeobox protein Lhx9; May be involved in gonadal development. (396 aa)
nkx3-2Bagpipe homeobox transcription factor Bapx1. (245 aa)
uncx4.1Homeobox protein unc-4 homolog; Transcription factor involved in somitogenesis and neurogenesis; Belongs to the paired homeobox family. Unc-4 subfamily. (470 aa)
isl2bInsulin gene enhancer protein isl-2b; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron. (358 aa)
en2bHomeobox protein engrailed-2b. (261 aa)
nkx2.3NK2 transcription factor related 3. (321 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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