STRINGSTRING
htra1a htra1a lnx2a lnx2a mpp6b mpp6b arhgef12a arhgef12a dlg1 dlg1 mpp5a mpp5a apba1b apba1b whrnb whrnb tjp2a tjp2a myo18aa myo18aa lin7c lin7c ptpn3 ptpn3 shank2b shank2b LOC559585 LOC559585 grid2ipb grid2ipb lmo7b lmo7b zgc:174193-2 zgc:174193-2 synj2bp synj2bp lmo7a lmo7a psmd9 psmd9 rhpn2 rhpn2 lin7a lin7a limk1b limk1b htra1b htra1b magi2a magi2a sdcbp2 sdcbp2 rgs12b rgs12b pdlim3b pdlim3b snx27b snx27b grip1 grip1 gipc2 gipc2 slc9a3r1a slc9a3r1a F1QJB0_DANRE F1QJB0_DANRE F1R6J1_DANRE F1R6J1_DANRE LOC100330882 LOC100330882 snx27a snx27a B8A626_DANRE B8A626_DANRE pdzd8 pdzd8 pdzk1 pdzk1 ptpn4b ptpn4b frmpd1b frmpd1b sntb1 sntb1 ush1c ush1c mast2 mast2 cnksr2b cnksr2b sipa1l1 sipa1l1 whrna whrna pdzrn3b pdzrn3b tiam1a tiam1a intu intu synpo2la synpo2la APBA3 APBA3 frmpd3 frmpd3 prex2 prex2 lnx2b lnx2b dlg5a dlg5a magi1b magi1b dvl1b dvl1b grasp grasp caska caska pdlim4 pdlim4 dvl3a dvl3a limk2 limk2 ppp1r9ala ppp1r9ala grip2a grip2a dlg4 dlg4 arhgap21b arhgap21b ahnak ahnak cytip cytip sipa1l2 sipa1l2 tax1bp3 tax1bp3 htra3a htra3a prex1 prex1 pdzd11 pdzd11 scrib scrib sntb2 sntb2 pdzrn4 pdzrn4 mast1a mast1a gopc gopc pard6gb pard6gb htra4 htra4 sdcbp sdcbp cnksr1 cnksr1 ldb3b ldb3b grid2ipa grid2ipa tiam2a tiam2a apba2b apba2b rgs12a rgs12a dvl3 dvl3 mpp7a mpp7a ENSDARP00000141176 ENSDARP00000141176 cnksr3 cnksr3 pdlim7 pdlim7 dlg2 dlg2 pdzd4 pdzd4 pard3ba pard3ba nos1 nos1 pdlim5a pdlim5a radil radil gipc1 gipc1 magi3a magi3a ENSDARP00000133527 ENSDARP00000133527 ppp1r9bb ppp1r9bb dlg1l dlg1l pclob pclob il16 il16 sntg2 sntg2 ppp1r9ba ppp1r9ba mpp3a mpp3a synpo2lb synpo2lb mpp6a mpp6a ppp1r9alb ppp1r9alb ppp1r9a ppp1r9a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
htra1aSerine protease HTRA1A; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] (479 aa)
lnx2aLigand of numb-protein X 2a. (737 aa)
mpp6bMembrane protein, palmitoylated 6b (MAGUK p55 subfamily member 6); Belongs to the MAGUK family. (539 aa)
arhgef12aRho guanine nucleotide exchange factor (GEF) 12a. (1357 aa)
dlg1Disks large homolog 1; Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction and cell proliferation (By similarity). May play a role in synapse assembly and function. Belongs to the MAGUK family. (909 aa)
mpp5aMAGUK p55 subfamily member 5-A; Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis (By similarity). Functions in cellular patterning of the retina. (703 aa)
apba1bAmyloid beta (A4) precursor protein-binding, family A, member 1b. (960 aa)
whrnbWhirlin b. (946 aa)
tjp2aTight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1198 aa)
myo18aaMyosin XVIIIAa; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2454 aa)
lin7cProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (201 aa)
ptpn3Protein tyrosine phosphatase non-receptor type 3. (839 aa)
shank2bSH3 and multiple ankyrin repeat domains 2b. (1800 aa)
LOC559585Si:dkey-84o3.2. (209 aa)
grid2ipbDelphilin; Postsynaptic scaffolding protein. (1368 aa)
lmo7bLIM domain 7b. (1384 aa)
zgc:174193-2Zgc:174193. (214 aa)
synj2bpSynaptojanin 2-binding protein. (152 aa)
lmo7aLIM domain 7a. (1826 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (211 aa)
rhpn2Rhophilin-2; Binds specifically to GTP-Rho. (683 aa)
lin7aProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (218 aa)
limk1bLIM domain kinase 1b. (615 aa)
htra1bSerine protease HTRA1B; Serine protease with a variety of targets, including extracellular matrix proteins and proteoglycans. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF- beta family members. Consequently, may regulate many physiological processes. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets ( [...] (476 aa)
magi2aMembrane-associated guanylate kinase, WW and PDZ domain-containing 2a. (1503 aa)
sdcbp2Syndecan-binding protein (syntenin) 2. (299 aa)
rgs12bRegulator of G protein-signaling 12b. (1540 aa)
pdlim3bPDZ and LIM domain 3b. (315 aa)
snx27bSorting nexin family member 27. (569 aa)
grip1Glutamate receptor-interacting protein 1. (1143 aa)
gipc2GIPC PDZ domain-containing family, member 2. (328 aa)
slc9a3r1aNa(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (384 aa)
F1QJB0_DANRESi:ch211-13f8.1. (1060 aa)
F1R6J1_DANRESi:dkey-121a11.3. (1060 aa)
LOC100330882Si:dkey-84o3.7. (200 aa)
snx27aSorting nexin 27a. (567 aa)
B8A626_DANRESi:dkey-33c12.12. (214 aa)
pdzd8PDZ domain-containing 8. (1180 aa)
pdzk1PDZ domain-containing 1. (553 aa)
ptpn4bTyrosine-protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (930 aa)
frmpd1bFERM and PDZ domain-containing 1b. (1656 aa)
sntb1Syntrophin, basic 1. (515 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
mast2Microtubule-associated serine/threonine kinase 2. (1934 aa)
cnksr2bConnector enhancer of kinase suppressor of Ras 2b. (963 aa)
sipa1l1Signal-induced proliferation-associated 1-like 1. (1794 aa)
whrnaWhirlin a. (939 aa)
pdzrn3bE3 ubiquitin-protein ligase PDZRN3-B; E3 ubiquitin-protein ligase. (1053 aa)
tiam1aTIAM Rac1-associated GEF 1a. (1621 aa)
intuProtein inturned; Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling (By similarity); Belongs to the inturned family. (926 aa)
synpo2laSynaptopodin 2-like a. (1179 aa)
APBA3Si:ch73-40i7.5. (742 aa)
frmpd3FERM and PDZ domain-containing 3. (1696 aa)
prex2Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2. (1600 aa)
lnx2bLigand of numb-protein X-like protein. (678 aa)
dlg5aDiscs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (1926 aa)
magi1bMembrane-associated guanylate kinase, WW and PDZ domain-containing 1b. (1247 aa)
dvl1bDishevelled segment polarity protein 1b. (716 aa)
graspGRP1 (General receptor for phosphoinositides 1)-associated scaffold protein like. (382 aa)
caskaCalcium/calmodulin-dependent serine protein kinase a; Belongs to the MAGUK family. (920 aa)
pdlim4PDZ and LIM domain 4. (349 aa)
dvl3aDishevelled segment polarity protein 3a. (676 aa)
limk2LIM domain kinase 2. (651 aa)
ppp1r9alaProtein phosphatase 1 regulatory subunit 9A-like A. (1332 aa)
grip2aGlutamate receptor-interacting protein 2a. (736 aa)
dlg4Disks large homolog 4; Plays a role in synapse assembly and function. Plays a role in synaptic plasticity. (707 aa)
arhgap21bRho GTPase-activating protein 21b. (1793 aa)
ahnakAHNAK nucleoprotein. (6417 aa)
cytipCytohesin 1-interacting protein. (343 aa)
sipa1l2Signal-induced proliferation-associated 1-like 2. (1672 aa)
tax1bp3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (125 aa)
htra3aHtrA serine peptidase 3a. (489 aa)
prex1Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1622 aa)
pdzd11PDZ domain-containing protein 11. (142 aa)
scribProtein scribble homolog; Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Regulates the caudal migration of the nVII motor neurons. Required for convergent extension movements during gastrulation. (1724 aa)
sntb2Syntrophin, beta 2. (519 aa)
pdzrn4PDZ domain-containing ring finger 4. (788 aa)
mast1aMicrotubule-associated serine/threonine kinase 1a. (1717 aa)
gopcGolgi-associated PDZ and coiled-coil motif-containing. (455 aa)
pard6gbPar-6 partitioning defective 6-like protein gamma. (434 aa)
htra4HtrA serine peptidase 4. (459 aa)
sdcbpSyndecan-binding protein (syntenin). (307 aa)
cnksr1Connector enhancer of kinase suppressor of Ras 1. (780 aa)
ldb3bLIM domain-binding 3b. (292 aa)
grid2ipaGlutamate receptor, ionotropic, delta 2 (Grid2)-interacting protein, a. (1804 aa)
tiam2aTIAM Rac1-associated GEF 2a. (1671 aa)
apba2bAmyloid beta (A4) precursor protein-binding, family A, member 2b. (833 aa)
rgs12aRegulator of G protein-signaling 12a. (1370 aa)
dvl3Dishevelled segment polarity protein 3b. (706 aa)
mpp7aMAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity). Belongs to the MAGUK family. (576 aa)
ENSDARP00000141176Si:dkeyp-72e1.9. (709 aa)
cnksr3Cnksr family member 3. (546 aa)
pdlim7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa)
dlg2Disks large homolog 2; May play a role in synapse assembly and function. (862 aa)
pdzd4PDZ domain-containing protein. (898 aa)
pard3baPar-3 family cell polarity regulator beta a. (1024 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
pdlim5aPDZ and LIM domain 5a. (551 aa)
radilRas-associating and dilute domain-containing protein; Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development. (1124 aa)
gipc1Regulator of G-protein signaling 19-interacting protein 1. (335 aa)
magi3aWu:fi36a10. (1355 aa)
ENSDARP00000133527Si:ch73-281f12.4. (1144 aa)
ppp1r9bbProtein phosphatase 1, regulatory subunit 9Bb. (801 aa)
dlg1lDiscs large homolog 1-like protein; May play a role in synapse assembly and function. (827 aa)
pclobPiccolo presynaptic cytomatrix protein b. (9346 aa)
il16Interleukin 16. (1521 aa)
sntg2Syntrophin, gamma 2. (540 aa)
ppp1r9baProtein phosphatase 1, regulatory subunit 9Ba. (803 aa)
mpp3aMembrane protein, palmitoylated 3a (MAGUK p55 subfamily member 3); Belongs to the MAGUK family. (591 aa)
synpo2lbSynaptopodin 2-like b. (1184 aa)
mpp6aMembrane protein, palmitoylated 6a (MAGUK p55 subfamily member 6); Belongs to the MAGUK family. (550 aa)
ppp1r9albProtein phosphatase 1 regulatory subunit 9A-like B. (1428 aa)
ppp1r9aProtein phosphatase 1, regulatory subunit 9A. (1068 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.