STRINGSTRING
fhl1b fhl1b lhx5 lhx5 lmo4a lmo4a limk2 limk2 lmo2 lmo2 lmo3 lmo3 csrp2 csrp2 lmo7b lmo7b micall2b micall2b zyx zyx crip1 crip1 micall1b.2 micall1b.2 fhl2b fhl2b nrap nrap ajuba ajuba micall1a micall1a prickle1b prickle1b mical2b mical2b limch1a limch1a fhl3a fhl3a lhx2a lhx2a mical1 mical1 zgc:195282 zgc:195282 mical3b mical3b lhx2b lhx2b lmcd1 lmcd1 limd2 limd2 wtip wtip limch1b limch1b LHX3 LHX3 pdlim4 pdlim4 crip2 crip2 fhl1a fhl1a pdlim5a pdlim5a lmo1 lmo1 micall2a micall2a prickle2b prickle2b mical3a mical3a F8W2V3_DANRE F8W2V3_DANRE csrp3 csrp3 pdlim7 pdlim7 ablim3 ablim3 trip6 trip6 zgc:56628 zgc:56628 lmx1ba lmx1ba csrp1a csrp1a lmx1a lmx1a isl1 isl1 fhl5 fhl5 pdlim3b pdlim3b lhx6 lhx6 isl2a isl2a lhx1a lhx1a limk1b limk1b lhx1b lhx1b lmo7a lmo7a ablim1b ablim1b lasp1 lasp1 lhx9 lhx9 isl2b isl2b lhx4 lhx4 prickle1a prickle1a fhl2a fhl2a tes tes scel scel lmx1bb lmx1bb lmo4b lmo4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fhl1bFour and a half LIM domains 1b. (280 aa)
lhx5LIM/homeobox protein Lhx5; Probably involved in the patterning of the nervous system, in particular in the early specification of the diencephalon. (399 aa)
lmo4aLIM domain only 4a. (167 aa)
limk2LIM domain kinase 2. (651 aa)
lmo2Rhombotin-2; Transcription factor that acts synergistically with tal1/scl in primitive and definitive hematopoiesis, and in endothelial development. Specifies mesodermal precursors to a hemangioblast cell fate. Hemangioblasts are bipotential precursors of blood and endothelium, and in the absence of hematopoietic induction cues such as gata1, tal1/scl-lmo2-induced haemangioblasts differentiate into endothelial cells. (159 aa)
lmo3LIM domain only protein 3. (167 aa)
csrp2Cysteine and glycine-rich protein 2. (193 aa)
lmo7bLIM domain 7b. (1384 aa)
micall2bMical-like 2b. (783 aa)
zyxZyxin. (608 aa)
crip1Cysteine-rich protein 1. (77 aa)
micall1b.2MICAL-like 1b, duplicate 2. (686 aa)
fhl2bFour and a half LIM domains 2b. (279 aa)
nrapNebulin-related-anchoring protein. (1861 aa)
ajubaAjuba LIM protein. (688 aa)
micall1aMICAL-like 1a. (867 aa)
prickle1bPrickle homolog 1b. (863 aa)
mical2bProtein-methionine sulfoxide oxidase mical2b; Nuclear monooxygenase that promotes depolymerization of F- actin by mediating oxidation of specific methionine residues on actin and regulates the srf signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Acts as a key regulator of the srf signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase mkl1/mrt [...] (1679 aa)
limch1aLIM and calponin homology domains 1a. (1019 aa)
fhl3aFour and a half LIM domains 3a. (279 aa)
lhx2aLIM homeobox 2a. (328 aa)
mical1[F-actin]-monooxygenase mical1; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and prevent repolymerization; Belongs to the Mical family. (1227 aa)
zgc:195282Zgc:195282. (80 aa)
mical3bProtein-methionine sulfoxide oxidase mical3b; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1673 aa)
lhx2bLIM homeobox 2b. (427 aa)
lmcd1LIM and cysteine-rich domains 1. (342 aa)
limd2LIM domain-containing 2. (114 aa)
wtipWilms tumor protein 1-interacting protein homolog; May monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Acts as a transcriptional corepressor for snai1 and snai2/slug and plays a role in regulating neural crest development (By similarity); Belongs to the zyxin/ajuba family. (648 aa)
limch1bLIM and calponin homology domains 1b. (1020 aa)
LHX3LIM/homeobox protein Lhx3. (398 aa)
pdlim4PDZ and LIM domain 4. (349 aa)
crip2Cysteine-rich protein 2. (206 aa)
fhl1aFour and a half LIM domains 1a. (297 aa)
pdlim5aPDZ and LIM domain 5a. (551 aa)
lmo1Rhombotin-1; May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. (175 aa)
micall2aMical-like 2a. (799 aa)
prickle2bPrickle homolog 2b. (840 aa)
mical3aProtein-methionine sulfoxide oxidase mical3a; Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process (By similarity); Belongs to the Mical family. (1994 aa)
F8W2V3_DANRESi:dkey-125i10.3. (745 aa)
csrp3Cysteine and glycine-rich protein 3 (cardiac LIM protein). (193 aa)
pdlim7PDZ and LIM domain protein 7; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues (By similarity). (419 aa)
ablim3Actin-binding LIM protein family, member 3. (684 aa)
trip6Uncharacterized protein. (571 aa)
zgc:56628Zgc:56628. (172 aa)
lmx1baLIM homeobox transcription factor 1, beta a. (375 aa)
csrp1aCysteine and glycine-rich protein 1a. (192 aa)
lmx1aLIM homeobox transcription factor 1, alpha. (366 aa)
isl1Insulin gene enhancer protein isl-1; DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. May be involved in subtype specialization of primary motoneurons. May bind to insulin gene enhancer sequences. Essential for heart development (By similarity). (349 aa)
fhl5Four and a half LIM domains 5. (280 aa)
pdlim3bPDZ and LIM domain 3b. (315 aa)
lhx6LIM homeobox 6. (375 aa)
isl2aInsulin gene enhancer protein isl-2a; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in subtype specialization of primary motoneurons. (359 aa)
lhx1aLIM/homeobox protein Lhx1; Seems to play a role in dorsal axis formation. (405 aa)
limk1bLIM domain kinase 1b. (615 aa)
lhx1bLIM class homeodomain protein. (402 aa)
lmo7aLIM domain 7a. (1826 aa)
ablim1bActin-binding LIM protein 1b. (354 aa)
lasp1LIM and SH3 protein 1. (234 aa)
lhx9LIM/homeobox protein Lhx9; May be involved in gonadal development. (396 aa)
isl2bInsulin gene enhancer protein isl-2b; Binds to one of the cis-acting domain of the insulin gene enhancer. May be involved in the regional specification of the myotome and also in target recognition by the caudal primary neuron. (358 aa)
lhx4LIM homeobox 4. (391 aa)
prickle1aPrickle homolog 1a. (793 aa)
fhl2aFour and a half LIM domains 2a. (279 aa)
tesTestis-derived transcript (3 LIM domains). (541 aa)
scelSciellin. (612 aa)
lmx1bbLIM homeobox transcription factor 1, beta 1. (375 aa)
lmo4bLIM domain only 4, like. (165 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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