STRINGSTRING
nrarpb nrarpb rfxank rfxank ankrd29 ankrd29 psmd10 psmd10 tp53bp2a tp53bp2a asb8 asb8 asb12a asb12a invs invs nfkbiab nfkbiab asb6 asb6 ankrd45 ankrd45 ankrd46b ankrd46b ankrd33ab ankrd33ab asb13a.1 asb13a.1 ankrd13b ankrd13b asb7 asb7 asap2a asap2a gabpb2a gabpb2a ppp1r13ba ppp1r13ba ankrd16 ankrd16 ankrd52a ankrd52a ankrd44 ankrd44 nfkbib nfkbib acap1 acap1 anks4b anks4b asb12b asb12b acbd6 acbd6 git1 git1 fank1 fank1 rai14 rai14 nfkbil1 nfkbil1 ppp1r12c ppp1r12c uacab uacab gpank1 gpank1 hectd1 hectd1 clip3 clip3 ankrd54 ankrd54 dzank1 dzank1 asb11 asb11 ankk1 ankk1 ilk ilk mphosph8 mphosph8 trpc4a trpc4a sowahcb sowahcb abtb2a abtb2a ankrd13a ankrd13a git2a git2a abtb2b abtb2b agap1 agap1 fem1b fem1b tnksb tnksb btbd11a btbd11a ankrd12 ankrd12 ehmt1a ehmt1a A2BIM2_DANRE A2BIM2_DANRE ankar ankar cttnbp2 cttnbp2 bcor bcor ankrd37 ankrd37 zdhhc17 zdhhc17 tonsl tonsl tanc1a tanc1a abtb1 abtb1 trpc6a trpc6a ankrd40 ankrd40 bcorl1 bcorl1 F1QHU6_DANRE F1QHU6_DANRE asb13b asb13b trpv6 trpv6 nfkbiaa nfkbiaa tnni3k tnni3k nrarpa nrarpa bcl3 bcl3 notch2 notch2 asb13a.2 asb13a.2 ankrd28b ankrd28b asb15b asb15b asb5a asb5a caiap caiap trpv1 trpv1 kidins220a kidins220a ankrd39 ankrd39 anks1b anks1b ankle2 ankle2 tnksa tnksa cdkn2c cdkn2c asb2a.1 asb2a.1 ankib1b ankib1b ppp1r12a ppp1r12a ankrd6b ankrd6b shank2b shank2b tp53bp2b tp53bp2b gabpb2b gabpb2b ankrd34c ankrd34c nfkb2 nfkb2 B8JLA1_DANRE B8JLA1_DANRE ankhd1 ankhd1 kidins220b kidins220b espn espn ankra2 ankra2 ankrd34ba ankrd34ba glsa glsa zgc:112001 zgc:112001 hace1 hace1 ppp1r16a ppp1r16a asb2a.2 asb2a.2 ankef1a ankef1a kank2 kank2 notchl notchl glsl glsl ankrd55 ankrd55 sncaip sncaip ankib1a ankib1a mib1 mib1 ostf1 ostf1 ank1a-2 ank1a-2 si:ch211-1o7.2 si:ch211-1o7.2 btbd11b btbd11b ankfy1 ankfy1 trpc4b trpc4b slf1 slf1 ankrd13c ankrd13c notch1a notch1a osbpl1a osbpl1a sowahca sowahca krit1 krit1 ankrd49 ankrd49 ankrd13d ankrd13d fem1c fem1c sowahab sowahab mtpn mtpn zdhhc13 zdhhc13 dgkza dgkza ankzf1 ankzf1 ibtk ibtk asb15a asb15a ankrd46a ankrd46a ppp1r27a ppp1r27a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
nrarpbNotch-regulated ankyrin repeat-containing protein B; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (111 aa)
rfxankRegulatory factor X-associated ankyrin-containing protein. (203 aa)
ankrd29Ankyrin repeat domain-containing protein 29. (298 aa)
psmd10Proteasome 26S subunit, non-ATPase, 10. (226 aa)
tp53bp2aTumor protein p53-binding protein, 2a. (1060 aa)
asb8Ankyrin repeat and SOCS box-containing 8. (289 aa)
asb12aAnkyrin repeat and SOCS box-containing 12a. (305 aa)
invsInversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa)
nfkbiabNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (312 aa)
asb6Ankyrin repeat and SOCS box-containing 6. (435 aa)
ankrd45Ankyrin repeat domain 45. (224 aa)
ankrd46bAnkyrin repeat domain-containing protein 46. (228 aa)
ankrd33abAnkyrin repeat domain 33Ab. (462 aa)
asb13a.1Ankyrin repeat and SOCS box-containing 13a, tandem duplicate 1. (286 aa)
ankrd13bAnkyrin repeat domain 13B. (632 aa)
asb7Ankyrin repeat and SOCS box-containing 7. (348 aa)
asap2aArfGAP with SH3 domain, ankyrin repeat and PH domain 2a. (991 aa)
gabpb2aGA-binding protein transcription factor subunit beta 2a. (407 aa)
ppp1r13baProtein phosphatase 1, regulatory subunit 13Ba. (1110 aa)
ankrd16Ankyrin repeat domain 16. (368 aa)
ankrd52aSerine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. (1071 aa)
ankrd44Ankyrin repeat domain 44. (1068 aa)
nfkbibNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta. (394 aa)
acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 1. (757 aa)
anks4bAnkyrin repeat and sterile alpha motif domain-containing 4B. (422 aa)
asb12bAnkyrin repeat and SOCS box-containing 12b. (308 aa)
acbd6Acyl-CoA-binding domain-containing protein 6; Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA. Does not bind fatty acids (By similarity). (300 aa)
git1G protein-coupled receptor kinase-interacting ArfGAP 1. (752 aa)
fank1Fibronectin type III and ankyrin repeat domains 1. (336 aa)
rai14Retinoic acid-induced 14. (988 aa)
nfkbil1Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1. (360 aa)
ppp1r12cProtein phosphatase 1, regulatory subunit 12C. (672 aa)
uacabUveal autoantigen with coiled-coil domains and ankyrin repeats b. (1371 aa)
gpank1G patch domain and ankyrin repeats 1. (208 aa)
hectd1Novel protein with HECT-domain (Ubiquitin-transferase). (2576 aa)
clip3CAP-GLY domain-containing linker protein 3. (539 aa)
ankrd54Ankyrin repeat domain-containing protein 54; Plays an important role in regulating intracellular signaling events associated with erythroid terminal differentiation. (315 aa)
dzank1Double zinc ribbon and ankyrin repeat domains 1. (752 aa)
asb11Ankyrin repeat and SOCS box containing protein a. (293 aa)
ankk1Ankyrin repeat and kinase domain-containing 1. (733 aa)
ilkIntegrin-linked kinase. (452 aa)
mphosph8M-phase phosphoprotein 8. (946 aa)
trpc4aTransient receptor potential cation channel, subfamily C, member 4a; Belongs to the transient receptor (TC 1.A.4) family. (934 aa)
sowahcbSosondowah ankyrin repeat domain family Cb. (438 aa)
abtb2aAnkyrin repeat and BTB (POZ) domain-containing 2a. (1006 aa)
ankrd13aAnkyrin repeat domain 13A. (623 aa)
git2aG protein-coupled receptor kinase-interacting ArfGAP 2a. (750 aa)
abtb2bAnkyrin repeat and BTB (POZ) domain-containing 2b. (1032 aa)
agap1ArfGAP with GTPase domain, ankyrin repeat and PH domain 1. (858 aa)
fem1bFem-1 homolog b. (638 aa)
tnksbPoly [ADP-ribose] polymerase. (1267 aa)
btbd11aAnkyrin repeat and BTB/POZ domain-containing protein BTBD11-A. (1021 aa)
ankrd12Ankyrin repeat domain 12. (1987 aa)
ehmt1aEuchromatic histone-lysine N-methyltransferase 1a. (1059 aa)
A2BIM2_DANRESi:ch211-203b8.6. (422 aa)
ankarAnkyrin and armadillo repeat-containing. (1400 aa)
cttnbp2Cortactin-binding protein 2. (1573 aa)
bcorBCL6 corepressor. (1796 aa)
ankrd37Ankyrin repeat domain 37. (167 aa)
zdhhc17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (620 aa)
tonslTonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks; Belongs to the Tonsoku family. (1427 aa)
tanc1aTetratricopeptide repeat, ankyrin repeat and coiled-coil-containing 1a. (1781 aa)
abtb1Ankyrin repeat and BTB (POZ) domain-containing 1. (476 aa)
trpc6aTransient receptor potential cation channel, subfamily C, member 6a; Belongs to the transient receptor (TC 1.A.4) family. (874 aa)
ankrd40Ankyrin repeat domain 40. (392 aa)
bcorl1BCL6 corepressor-like 1. (1514 aa)
F1QHU6_DANREPalmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (544 aa)
asb13bAnkyrin repeat and SOCS box-containing 13b. (294 aa)
trpv6Transient receptor potential cation channel, subfamily V, member 6; Belongs to the transient receptor (TC 1.A.4) family. (709 aa)
nfkbiaaNuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (310 aa)
tnni3kTNNI3-interacting kinase. (835 aa)
nrarpaNotch-regulated ankyrin repeat-containing protein A; Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development; Belongs to the NRARP family. (112 aa)
bcl3BCL3 transcription coactivator. (619 aa)
notch2Notch receptor 2. (2475 aa)
asb13a.2Ankyrin repeat and SOCS box-containing 13a, tandem duplicate 2. (280 aa)
ankrd28bAnkyrin repeat domain 28b. (1052 aa)
asb15bAnkyrin repeat and SOCS box-containing 15b. (584 aa)
asb5aAnkyrin repeat and SOCS box-containing 5a. (331 aa)
caiapCARD- and ANK-domain containing inflammasome adapter protein; Probable inflammasome component which mediates inflammasome- dependent resistance to bacterial infection by S.typhimurium through association with activated caspa. (744 aa)
trpv1Transient receptor potential cation channel, subfamily V, member 1; Belongs to the transient receptor (TC 1.A.4) family. (813 aa)
kidins220aKinase D-interacting substrate 220a. (1694 aa)
ankrd39Ankyrin repeat domain 39. (182 aa)
anks1bAnkyrin repeat and sterile alpha motif domain-containing protein 1B. (1280 aa)
ankle2Ankyrin repeat and LEM domain-containing 2. (961 aa)
tnksaPoly [ADP-ribose] polymerase. (1252 aa)
cdkn2cCyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (170 aa)
asb2a.1Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (689 aa)
ankib1bRBR-type E3 ubiquitin transferase. (1074 aa)
ppp1r12aProtein phosphatase 1 regulatory subunit 12A; Regulates myosin phosphatase activity. (1117 aa)
ankrd6bAnkyrin repeat domain 6b. (728 aa)
shank2bSH3 and multiple ankyrin repeat domains 2b. (1800 aa)
tp53bp2bTumor protein p53-binding protein, 2b. (1060 aa)
gabpb2bGA-binding protein transcription factor subunit beta 2b. (418 aa)
ankrd34cANK_REP_REGION domain-containing protein. (531 aa)
nfkb2Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (902 aa)
B8JLA1_DANRESi:ch211-168b3.1. (824 aa)
ankhd1Ankyrin repeat and KH domain-containing 1. (2607 aa)
kidins220bKinase D-interacting substrate of 220 kDa B; Downstream target for both neurotrophin and ephrin receptors. May play a role in nerve growth factor (NGF)-induced recruitment of rapgef2 to late endosomes and neurite outgrowth. (1680 aa)
espnEspin. (873 aa)
ankra2Ankyrin repeat, family A (RFXANK-like), 2. (301 aa)
ankrd34baAnkyrin repeat domain 34Ba. (544 aa)
glsaGlutaminase a. (591 aa)
zgc:112001Zgc:112001. (280 aa)
hace1E3 ubiquitin-protein ligase HACE1; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. (905 aa)
ppp1r16aProtein phosphatase 1, regulatory subunit 16A. (553 aa)
asb2a.2Ankyrin repeat and SOCS box-containing 2a, tandem duplicate 1. (661 aa)
ankef1aAnkyrin repeat and EF-hand domain-containing protein 1a. (779 aa)
kank2KN motif and ankyrin repeat domain-containing protein 2; May be involved in different biological processes including transcription and apoptosis by sequestering specific proteins outside of the nucleus (By similarity). Involved in actin stress fibers formation probably through its interaction with ARHGDIA and the regulation of the Rho signaling pathway (By similarity). May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. (1085 aa)
notchlNotch receptor,-like. (784 aa)
glslGlutaminase-like. (643 aa)
ankrd55Ankyrin repeat domain 55. (650 aa)
sncaipSynuclein, alpha-interacting protein. (738 aa)
ankib1aAnkyrin repeat and IBR domain-containing protein 1; Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates. (1060 aa)
mib1E3 ubiquitin-protein ligase mib1; E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. It thereby participates in many processes regulated by the Notch signaling pathway, such as midline cell fate specification prior to germ layer formation, patterning of sensory cell differentiation in the ear, neurogenesis of the hindbrain and commitment to a secretory fate in the intesti [...] (1041 aa)
ostf1Osteoclast-stimulating factor 1; Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity. (214 aa)
ank1a-2Ankyrin 1, erythrocytic a. (1969 aa)
si:ch211-1o7.2Si:ch211-1o7.2. (246 aa)
btbd11bAnkyrin repeat and BTB/POZ domain-containing protein BTBD11-B. (1042 aa)
ankfy1Ankyrin repeat and FYVE domain-containing 1. (1167 aa)
trpc4bTransient receptor potential cation channel, subfamily C, member 4b; Belongs to the transient receptor (TC 1.A.4) family. (915 aa)
slf1SMC5-SMC6 complex localization factor 1. (897 aa)
ankrd13cAnkyrin repeat domain-containing protein 13C; Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER. (488 aa)
notch1aNeurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] (2438 aa)
osbpl1aOxysterol-binding protein; Belongs to the OSBP family. (972 aa)
sowahcaSosondowah ankyrin repeat domain family Ca. (505 aa)
krit1Krev interaction trapped protein 1; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. Negative regulator of angiogenesis. Inhibits endothelial proliferation, apoptosis, migration, lumen formation and sprouting angiogenesis in primary endothelial cells. Plays a role in integrin signaling. Plays an important role in the maintenance of the intracellular reactive oxygen species (ROS) homeostasis to prevent oxidative cellular damage. Facilitates the down-regulation of cyclin-D1 (CCND1) levels required for cell transition from pr [...] (741 aa)
ankrd49Ankyrin repeat domain 49. (218 aa)
ankrd13dAnkyrin repeat domain 13 family, member D. (624 aa)
fem1cProtein fem-1 homolog C; Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit; Belongs to the fem-1 family. (438 aa)
sowahabSosondowah ankyrin repeat domain family member Ab. (444 aa)
mtpnMyotrophin; Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity); Belongs to the myotrophin family. (118 aa)
zdhhc13Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (645 aa)
dgkzaDiacylglycerol kinase. (1222 aa)
ankzf1Ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1. (723 aa)
ibtkInhibitor of Bruton agammaglobulinemia tyrosine kinase. (1332 aa)
asb15aAnkyrin repeat and SOCS box-containing 15a. (563 aa)
ankrd46aAnkyrin repeat domain 46a. (228 aa)
ppp1r27aANK_REP_REGION domain-containing protein. (226 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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