(37 nodes) p53-like transcription factor, DNA-binding domain superfamily network (Danio rerio)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

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textmining

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Your Input:
	stat1b	Signal transducer and activator of transcription. (725 aa)
	tbx21	T-box transcription factor 21. (609 aa)
	tbx4	T-box transcription factor 4. (543 aa)
	tbx6	T-box transcription factor TBX6; T-box transcription factor involved in the development of paraxial mesoderm. (874 aa)
	tbr1b	T-box brain transcription factor 1b. (676 aa)
	stat5a	Signal transducer and activator of transcription. (785 aa)
	tbx3a	T-box transcription factor 3a. (689 aa)
	rbpja	Recombination signal-binding protein for immunoglobulin kappa J region a. (496 aa)
	stat6	Signal transducer and activator of transcription. (758 aa)
	tbx20	T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors. (446 aa)
	tbx2a	T-box transcription factor 2a. (686 aa)
	tbx5a	T-box transcription factor TBX5-A; Required for pectoral fin formation. Together with tbx5b, involved in eye and heart development. Required for the looping stage of heart development. May bind to the core DNA motif of promoters. (492 aa)
	tbr1a	T-box brain transcription factor 1a. (585 aa)
	tbx1	T-box transcription factor TBX1; May act as a transcriptional factor. Acts cell autonomously in the pharyngeal mesendoderm and influences the development of neural crest-derived cartilages secondarily. (460 aa)
	nfatc3a	Nuclear factor of-activated T cells 3a. (1074 aa)
	rel	V-rel avian reticuloendotheliosis viral oncogene homolog. (596 aa)
	rbpjb	Recombination signal-binding protein for immunoglobulin kappa J region b. (491 aa)
	stat3	Signal transducer and activator of transcription. (806 aa)
	LOC571865	Nuclear factor of-activated T cells 2b. (792 aa)
	nfatc4	Nuclear factor of-activated T cells 4. (865 aa)
	tbx2b	T-box transcription factor TBX2b; Involved in the transcriptional regulation of genes required for mesoderm differentiation. Plays a role in the specification of late notochordal precursor cells and formation of the differentiated notochord. Required for cardiac atrioventricular canal formation. (687 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (640 aa)
	tbx3b	T-box transcription factor 3b. (594 aa)
	runx1	Runt-related transcription factor. (451 aa)
	tbx16l	T-box transcription factor TBX6L; Probable transcriptional regulator involved in developmental processes. (488 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
	nfatc3b	Nuclear factor of-activated T cells 3b. (923 aa)
	tbx22	T-box transcription factor 22. (334 aa)
	nfkb2	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100). (902 aa)
	rela	V-rel avian reticuloendotheliosis viral oncogene homolog A. (455 aa)
	nfat5b	Nuclear factor of-activated T cells 5b. (1257 aa)
	nfkb1	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1. (540 aa)
	nfatc2a	Nuclear factor of-activated T cells 2a. (894 aa)
	eomesb	Eomesodermin homolog b. (534 aa)
	tbxta	T-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
	mgaa	MAX dimerization protein MGA a. (2838 aa)
	eomesa	T-box transcription factor eomesodermin. (661 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC571865	nfatc2a	ENSDARP00000098057	ENSDARP00000138593	Nuclear factor of-activated T cells 2b.	Nuclear factor of-activated T cells 2a.	0.904
nfatc2a	LOC571865	ENSDARP00000138593	ENSDARP00000098057	Nuclear factor of-activated T cells 2a.	Nuclear factor of-activated T cells 2b.	0.904
nfatc2a	nfatc3a	ENSDARP00000138593	ENSDARP00000067888	Nuclear factor of-activated T cells 2a.	Nuclear factor of-activated T cells 3a.	0.615
nfatc3a	nfatc2a	ENSDARP00000067888	ENSDARP00000138593	Nuclear factor of-activated T cells 3a.	Nuclear factor of-activated T cells 2a.	0.615
nfatc3a	nfatc3b	ENSDARP00000067888	ENSDARP00000120657	Nuclear factor of-activated T cells 3a.	Nuclear factor of-activated T cells 3b.	0.909
nfatc3b	nfatc3a	ENSDARP00000120657	ENSDARP00000067888	Nuclear factor of-activated T cells 3b.	Nuclear factor of-activated T cells 3a.	0.909
nfkb1	nfkb2	ENSDARP00000135800	ENSDARP00000121285	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	0.463
nfkb1	rel	ENSDARP00000135800	ENSDARP00000072078	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.656
nfkb1	rela	ENSDARP00000135800	ENSDARP00000133181	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.988
nfkb1	tp53	ENSDARP00000135800	ENSDARP00000116736	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.529
nfkb2	nfkb1	ENSDARP00000121285	ENSDARP00000135800	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	0.463
nfkb2	rel	ENSDARP00000121285	ENSDARP00000072078	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	V-rel avian reticuloendotheliosis viral oncogene homolog.	0.965
nfkb2	rela	ENSDARP00000121285	ENSDARP00000133181	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.762
nfkb2	stat3	ENSDARP00000121285	ENSDARP00000095292	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	Signal transducer and activator of transcription.	0.465
nfkb2	tp53	ENSDARP00000121285	ENSDARP00000116736	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100).	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.533
rbpja	rbpjb	ENSDARP00000026585	ENSDARP00000087012	Recombination signal-binding protein for immunoglobulin kappa J region a.	Recombination signal-binding protein for immunoglobulin kappa J region b.	0.903
rbpja	tbx20	ENSDARP00000026585	ENSDARP00000026669	Recombination signal-binding protein for immunoglobulin kappa J region a.	T-box transcription factor TBX20; Transcriptional regulator that may play a very early role in the differentiation of the cardiac precursors.	0.566
rbpja	tp53	ENSDARP00000026585	ENSDARP00000116736	Recombination signal-binding protein for immunoglobulin kappa J region a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression.	0.630
rbpjb	rbpja	ENSDARP00000087012	ENSDARP00000026585	Recombination signal-binding protein for immunoglobulin kappa J region b.	Recombination signal-binding protein for immunoglobulin kappa J region a.	0.903
rel	nfkb1	ENSDARP00000072078	ENSDARP00000135800	V-rel avian reticuloendotheliosis viral oncogene homolog.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.	0.656

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