STRINGSTRING
thraa thraa nr2f6b nr2f6b rxrgb rxrgb rxrab rxrab esrrga esrrga nr2f6a nr2f6a nr2f1b nr2f1b nr2e1 nr2e1 rorab rorab gata3 gata3 nr6a1b nr6a1b rxrbb rxrbb gata5 gata5 nr5a1b nr5a1b nr2f5 nr2f5 rarab rarab rarga rarga nr3c1 nr3c1 nr4a3 nr4a3 raraa raraa rxraa rxraa gata2a gata2a esr1 esr1 ar ar esrrgb esrrgb nr1d1 nr1d1 nr5a5 nr5a5 rorcb rorcb nr1h5 nr1h5 nr1i2 nr1i2 roraa roraa pparaa pparaa nr2f2 nr2f2 nr2c2 nr2c2 ppardb ppardb esr2a esr2a nr1d2b nr1d2b nr2f1a nr2f1a esr2b esr2b gata2b gata2b hnf4g hnf4g pparda pparda vdrb vdrb rxrba rxrba pparab pparab thrab thrab nr1d2a nr1d2a nr5a1a nr5a1a nr3c2 nr3c2 nr2c1 nr2c1 gata6 gata6 trps1 trps1 nr1h3 nr1h3 nr5a2 nr5a2 rargb rargb esrra esrra nr6a1a nr6a1a thrb thrb
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
experimentally determined
Predicted Interactions
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thraaThyroid hormone receptor alpha-A; High affinity receptor for triiodothyronine (By similarity). In the absence of thyroid hormone during late blastula stage development, acts as a transcriptional repressor. Whereas in the presence of thyroid hormone, can act as an activator of transcription. In addition, represses retinoic acid (RA)-signaling during blastula and gastrula stages of development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (427 aa)
nr2f6bNuclear receptor subfamily 2, group F, member 6b. (404 aa)
rxrgbRetinoic acid receptor RXR-gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity). (452 aa)
rxrabRetinoic acid receptor RXR-alpha-B; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes (By similarity). The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription (By similarity). The high affinity ligand for rxrs is 9- cis retinoic acid (By similarity). [...] (379 aa)
esrrgaEstrogen-related receptor gamma a. (501 aa)
nr2f6aNuclear receptor subfamily 2, group F, member 6a. (402 aa)
nr2f1bNuclear receptor subfamily 2 group F member 1-B; Putative transcription factor that is required in photoreceptor cells precursors during eye development; Belongs to the nuclear hormone receptor family. NR2 subfamily. (389 aa)
nr2e1Nuclear receptor subfamily 2, group E, member 1. (396 aa)
rorabNuclear receptor ROR-alpha B; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development (By similarity); Belongs to the nuclear hormone receptor family. (474 aa)
gata3Transcription factor GATA-3. (438 aa)
nr6a1bNuclear receptor subfamily 6 group A member 1-B; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity). (455 aa)
rxrbbRetinoic acid receptor RXR-beta-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily. (422 aa)
gata5Transcription factor gata5. (383 aa)
nr5a1bNovel protein similar to Carassius auratus nuclear hormone receptor FTZ-F1. (502 aa)
nr2f5Nuclear receptor subfamily 2 group F member 5; Putative receptor that is required in photoreceptor cells precursors during eye development; Belongs to the nuclear hormone receptor family. NR2 subfamily. (403 aa)
rarabRetinoic acid receptor alpha-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and, in lateral plate mesoderm, for specification of the pectoral fins; Belongs to the nuclear hormone receptor family. NR1 subfamily. (458 aa)
rargaRetinoic acid receptor gamma-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development and for the development of pharyngeal arches; Belongs to the nuclear hormone receptor family. NR1 subfamily. (499 aa)
nr3c1Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (746 aa)
nr4a3Nuclear receptor subfamily 4, group A, member 3. (594 aa)
raraaRetinoic acid receptor alpha-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain patterning; Belongs to the nuclear hormone receptor family. NR1 subfamily. (444 aa)
rxraaRetinoic acid receptor RXR-alpha-A; Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 to regulate transcription. The high affinity ligand for rxrs is 9-cis retinoic acid. In the absence of ligand, the rar/rxr heterodimer [...] (458 aa)
gata2aGATA-binding protein 2a. (456 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
arAndrogen receptor. (868 aa)
esrrgbEstrogen-related receptor gamma b. (444 aa)
nr1d1Nuclear receptor subfamily 1, group d, member 1. (637 aa)
nr5a5Nuclear receptor subfamily 5, group A, member 5. (537 aa)
rorcbRAR-related orphan receptor C b. (480 aa)
nr1h5Nuclear receptor subfamily 1, group H, member 5. (486 aa)
nr1i2Nuclear receptor subfamily 1, group I, member 2. (430 aa)
roraaNuclear receptor ROR-alpha A; Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) (By similarity). Required for proper cerebellum development. (468 aa)
pparaaPeroxisome proliferator-activated receptor alpha a. (470 aa)
nr2f2Drosophila seven-up homolog/mammalian ARP-1 homolog. (422 aa)
nr2c2Nuclear receptor subfamily 2, group C, member 2. (623 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
esr2aEstrogen receptor beta2. (553 aa)
nr1d2bNuclear receptor subfamily 1, group D, member 2b. (578 aa)
nr2f1aNuclear receptor subfamily 2 group F member 1-A; Putative transcription factor that is required in photoreceptor cells precursors during eye development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (411 aa)
esr2bEstrogen receptor 2b. (592 aa)
gata2bGATA-binding protein 2b. (428 aa)
hnf4gHepatocyte nuclear factor 4, gamma. (458 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
vdrbVitamin D3 receptor B; Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3- responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. (422 aa)
rxrbaRetinoic acid receptor RXR-beta-A; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity); Belongs to the nuclear hormone receptor family. NR2 subfamily. (471 aa)
pparabPeroxisome proliferator-activated receptor alpha b. (459 aa)
thrabThyroid hormone receptor alpha b. (409 aa)
nr1d2aNuclear receptor subfamily 1, group D, member 2a. (504 aa)
nr5a1aNuclear receptor subfamily 5, group A, member 1a. (454 aa)
nr3c2Nuclear receptor subfamily 3, group C, member 2. (970 aa)
nr2c1Nuclear receptor subfamily 2, group C, member 1. (600 aa)
gata6GATA-binding protein 6. (501 aa)
trps1Trichorhinophalangeal syndrome I. (1243 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
rargbRetinoic acid receptor gamma-B; Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Required for hindbrain development; Belongs to the nuclear hormone receptor family. NR1 subfamily. (392 aa)
esrraEstrogen-related receptor alpha. (436 aa)
nr6a1aNuclear receptor subfamily 6 group A member 1-A; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity). Belongs to the nuclear hormone receptor family. NR6 subfamily. (477 aa)
thrbThyroid hormone receptor beta; Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for the thyroid gland hormone triiodothyronine (T3). Transactivating activity is ligand-dependent, and is repressed in the absence of T3. (508 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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