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| | fzr1a | Fizzy/cell division cycle 20 related 1 (Drosophila). (495 aa) |
| | seh1l | Nucleoporin SEH1; Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore. Belongs to the WD repeat SEC13 family. (364 aa) |
| | utp4 | Cirrhosis, autosomal recessive 1A (Cirhin). (685 aa) |
| | pwp1 | PWP1 homolog (S. cerevisiae). (490 aa) |
| | DMWD | Zmp:0000000529. (684 aa) |
| | wdr12 | Ribosome biogenesis protein wdr12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (422 aa) |
| | arpc1a | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa) |
| | gnb3b | Guanine nucleotide-binding protein (G protein), beta polypeptide 3b. (338 aa) |
| | wsb1 | WD repeat and SOCS box-containing protein 1; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. (423 aa) |
| | wdfy1 | WD repeat and FYVE domain-containing 1. (410 aa) |
| | apaf1 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). (1261 aa) |
| | wdr24 | GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (779 aa) |
| | wdr36 | WD repeat domain 36. (896 aa) |
| | gtf3c2 | General transcription factor IIIC, polypeptide 2, beta. (853 aa) |
| | dync1i2a | Dynein, cytoplasmic 1, intermediate chain 2a; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (By similarity). Plays a role in the development of anterior brain and cartilaginous structures. Belongs to the dynein intermediate chain family. (626 aa) |
| | coro2a | Coronin; Belongs to the WD repeat coronin family. (533 aa) |
| | rae1 | mRNA export factor; Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Belongs to the WD repeat rae1 family. (368 aa) |
| | plxnb3 | Plexin B3. (1886 aa) |
| | nedd1 | NEDD1 gamma-tubulin ring complex targeting factor. (677 aa) |
| | gnb3a | Novel protein similar to guanine nucleotide binding protein (G protein) beta polypeptide family. (340 aa) |
| | fbxw11b | F-box and WD repeat domain-containing 11b. (531 aa) |
| | eif3i | Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (325 aa) |
| | wdr5 | WD repeat domain 5. (334 aa) |
| | wdr55 | WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis (By similarity). (386 aa) |
| | nol10 | Nucleolar protein 10. (722 aa) |
| | wdr54 | WD repeat domain 54. (339 aa) |
| | wdr82 | WD repeat-containing protein 82; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus; Belongs to the WD repeat SWD2 family. (313 aa) |
| | plxna4 | Plexin-A4; Involved in the development of primary sensory neurons especially in branching of the peripheral axons. Interacts with the SLIT2 signaling specifically to promote axonal branching of Rohon-Beard neurons and the trigeminal sensory ganglion neurons. (1903 aa) |
| | nup133 | Nuclear pore complex protein Nup133; Involved in poly(A)+ RNA transport (By similarity). Involved in nephrogenesis. (1136 aa) |
| | katnb1 | Katanin p80 WD40 repeat-containing subunit B1; Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Belongs to the WD repeat KATNB1 family. (694 aa) |
| | poc1b | POC1 centriolar protein homolog B; Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Belongs to the WD repeat POC1 family. (490 aa) |
| | coro1ca | Coronin-1C-A; Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (Probable). Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. [...] (474 aa) |
| | stxbp5l | Syntaxin-binding protein 5-like; May play a role in vesicle trafficking and exocytosis. Belongs to the WD repeat L(2)GL family. (1159 aa) |
| | dcaf11 | DDB1- and CUL4-associated factor 11; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat LEC14B family. (541 aa) |
| | dcaf13 | DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (445 aa) |
| | wdr73 | WD repeat-containing protein 73; May play a role in the regulation of microtubule organization and dynamics; Belongs to the WD repeat WDR73 family. (376 aa) |
| | dtl | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (647 aa) |
| | llgl2 | LLGL scribble cell polarity complex component 2; Essential for hemidesmosome formation and maintenance of the cytoskeleton elements as well as cellular morphology in the basal epidermis during development. Also involved in regulating growth of the basal epidermis; Belongs to the WD repeat L(2)GL family. (1020 aa) |
| | wdr26b | WD repeat-containing protein 26; G-beta-like protein involved in cell signal transduction. Acts as a negative regulator in MAPK signaling pathway. Functions as a scaffolding protein to promote G beta:gamma-mediated PLCB2 plasma membrane translocation and subsequent activation in leukocytes. Core component of the CTLH E3 ubiquitin-protein ligase complex that mediates ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Acts as a negative regulator of the canonical Wnt signaling pathway through preventing ubiquitination of beta-catenin CTNNB1 by the b [...] (576 aa) |
| | arpc1b | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (369 aa) |
| | snrnp40 | Small nuclear ribonucleoprotein 40 (U5). (347 aa) |
| | sema3ga | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ga; Belongs to the semaphorin family. (749 aa) |
| | pafah1b1b | Lissencephaly-1 homolog B; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration (By similarity). Involved in the positioning of nuclei in photoreceptor cells. (410 aa) |
| | pafah1b1a | Lissencephaly-1 homolog A; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration; Belongs to the WD repeat LIS1/nudF family. (410 aa) |
| | fbxw4 | F-box and WD repeat domain-containing 4. (392 aa) |
| | plxna3 | Plexin A3; Coreceptor for class 3 semaphorins. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. (1892 aa) |
| | tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) |
| | sema3fa | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (801 aa) |
| | sema3bl | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (771 aa) |
| | wdr32 | DDB1- and CUL4-associated factor 10; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; Belongs to the WD repeat DCAF10 family. (508 aa) |
| | nbas | Neuroblastoma-amplified sequence; Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (By similarity). (2372 aa) |
| | rbbp4 | Histone-binding protein RBBP4; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (424 aa) |
| | lrwd1 | Leucine-rich repeat and WD repeat-containing protein 1; Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post- replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability (By similarity); Belongs to the LRWD1 family. (763 aa) |
| | gnb2 | Guanine nucleotide-binding protein (G protein), beta polypeptide 2. (340 aa) |
| | sema3aa | Semaphorin-3aa; May influence outgrowth by a variety of growth cones including those of the posterior lateral line ganglion. (860 aa) |
| | sema3e | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (768 aa) |
| | wdr92 | WD repeat-containing protein 92; Seems to act as a modulator of apoptosis. (358 aa) |
| | thoc6 | THO complex subunit 6 homolog; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap- dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway (By similarity); Belongs to t [...] (323 aa) |
| | wdr48b | WD repeat-containing protein 48; Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. (677 aa) |
| | dcaf7 | Ddb1 and cul4-associated factor 7. (342 aa) |
| | anapc4 | Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (797 aa) |
| | wdfy2 | WD repeat and FYVE domain-containing 2. (400 aa) |
| | wdr75 | WD repeat-containing protein 75; Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. (832 aa) |
| | med16 | Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (847 aa) |
| | wdr18 | WD repeat-containing protein 18; Involved in left-right determination through controlling the correct clustering and migration of dorsal forerunner cells (DFCs) and Kupffer's vesicle formation. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit (By similarity). (431 aa) |
| | wdr83 | WD repeat domain-containing protein 83; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha (By similarity); Belongs to the WD repeat MORG1 family. (315 aa) |
| | bbs2 | Bardet-Biedl syndrome 2 protein homolog; Required for ciliogenesis. (715 aa) |
| | rack1 | Guanine nucleotide-binding protein subunit beta-2-like 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Required for VANGL2 membrane localization, inhibits Wnt signaling and regulates cellular polarization and oriented cell division during gastrulation; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa) |
| | ift172 | Intraflagellar transport protein 172 homolog; Required for the maintenance and formation of cilia. (1745 aa) |
| | sema3ab | Semaphorin-3ab; Might normally influence the midsegmental pathway choice of the ventrally extending motor axons by contributing to a repulsive domain in the posterior somite. (778 aa) |
| | sema3h | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3H; Belongs to the semaphorin family. (749 aa) |
| | tbl2 | Transducin beta-like 2. (439 aa) |
| | eipr1 | EARP-interacting protein homolog; Belongs to the WD repeat EIPR1 family. (391 aa) |
| | wdr78 | WD repeat domain 78. (778 aa) |
| | pak1ip1 | P21-activated protein kinase-interacting protein 1-like; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly. (368 aa) |
| | nsmaf | Neutral sphingomyelinase (N-SMase) activation-associated factor. (911 aa) |
| | smu1b | SMU1 DNA replication regulator and spliceosomal factor b. (539 aa) |
| | wdr76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (553 aa) |
| | coro1a | Coronin; Belongs to the WD repeat coronin family. (455 aa) |
| | sec13 | SEC13 homolog, nuclear pore and COPII coat complex component; Belongs to the WD repeat SEC13 family. (320 aa) |
| | gnb5b | Guanine nucleotide-binding protein subunit beta-5b; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] (395 aa) |
| | thoc3 | THO complex 3. (322 aa) |
| | chaf1b | Chromatin assembly factor 1, subunit B. (613 aa) |
| | wdr34 | WD repeat domain 34. (501 aa) |
| | ciao1 | Probable cytosolic iron-sulfur protein assembly protein ciao1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family. (330 aa) |
| | wdr66 | WD repeat domain 66. (963 aa) |
| | wdr44 | WD repeat domain 44. (904 aa) |
| | dcaf5 | Ddb1 and cul4-associated factor 5. (789 aa) |
| | tbl1x | Transducin beta-like 1 X-linked. (510 aa) |
| | kctd3 | Potassium channel tetramerization domain-containing 3. (821 aa) |
| | dync1i1 | Dynein, cytoplasmic 1, intermediate chain 1. (627 aa) |
| | dph7 | Diphthamide biosynthesis 7. (443 aa) |
| | edc4 | Enhancer of mRNA-decapping protein 4; In the process of mRNA degradation, seems to play a role in mRNA decapping; Belongs to the WD repeat EDC4 family. (1395 aa) |
| | ppp2r2cb | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa) |
| | sema4ab | Semaphorin-4A isoform X1; Belongs to the semaphorin family. (831 aa) |
| | dcaf12 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (482 aa) |
| | prpf4 | PRP4 pre-mRNA-processing factor 4 homolog (yeast). (507 aa) |
| | ambra1a | Activating molecule in beclin-1-regulated autophagy. (1315 aa) |
| | smu1a | WD40 repeat-containing protein SMU1; Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Required for normal accumulation of ik (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). Belongs to the WD repeat SMU1 family. (513 aa) |
| | stxbp5b | Syntaxin-binding protein 5b (tomosyn). (1123 aa) |
| | sema6dl | Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D,-like. (1018 aa) |
| | wdr35 | WD repeat-containing protein 35. (1203 aa) |
| | ddb2 | DNA damage-binding protein 2; Required for DNA repair. Binds to ddb1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex which may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV- induced DNA damage. The ubiquitination of histones may facilitate their removal from th [...] (497 aa) |
| | sema3d | Semaphorin-3D; May play a role in the guidance of several axon pathways. (764 aa) |
| | nbeaa | Neurobeachin a. (2998 aa) |
| | zgc:86896 | Actin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (357 aa) |
| | emc1 | ER membrane protein complex subunit 1. (964 aa) |
| | hps5 | Hermansky-Pudlak syndrome 5 protein homolog; May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. (1133 aa) |
| | M9MMA2_DANRE | Si:ch211-129c21.1; Belongs to the semaphorin family. (775 aa) |
| | prpf19 | PRP19/PSO4 homolog (S. cerevisiae). (505 aa) |
| | wdr62 | WD repeat domain 62. (1493 aa) |
| | sema4c | Semaphorin-4C precursor; Belongs to the semaphorin family. (863 aa) |
| | wdr20a | WD repeat domain 20a. (596 aa) |
| | poc1a | POC1 centriolar protein homolog A; May play an important role in centriole assembly and/or stability and ciliogenesis. (182 aa) |
| | wdtc1 | WD and tetratricopeptide repeats 1. (674 aa) |
| | Q5RHX7_DANRE | Si:ch211-127b11.1 protein. (477 aa) |
| | tbc1d31 | TBC1 domain family, member 31. (1070 aa) |
| | sema4e | Semaphorin-4E. (766 aa) |
| | wdr90 | WD repeat domain 90. (1843 aa) |
| | sorcs2 | Sortilin-related VPS10 domain-containing receptor 2. (1133 aa) |
| | wdr17 | WD repeat domain 17. (1307 aa) |
| | sema4bb | Semaphorin-4B; Belongs to the semaphorin family. (849 aa) |
| | dcaf6 | Ddb1 and cul4-associated factor 6. (907 aa) |
| | wdr89 | WD repeat domain 89. (379 aa) |
| | sec31a | Protein transport protein Sec31A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1250 aa) |
| | nwd2 | NACHT and WD repeat domain-containing 2. (1735 aa) |
| | elp2 | Elongator complex protein 2; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs; Belongs to the WD repeat ELP2 family. (836 aa) |
| | eml1 | EMAP-like 1. (813 aa) |
| | sema3gb | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Gb; Belongs to the semaphorin family. (745 aa) |
| | tbl1xr1a | Tbl1x receptor 1a. (416 aa) |
| | wdsub1 | WD repeat, SAM and U-box domain-containing protein 1. (487 aa) |
| | utp15 | U3 small nucleolar RNA-associated protein 15 homolog; Involved in nucleolar processing of pre-18S ribosomal RNA. (517 aa) |
| | wrap73 | WD repeat-containing, antisense to TP73. (446 aa) |
| | wdr41 | WD repeat domain 41. (449 aa) |
| | wdr4 | tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wdr4; Non-catalytic component of a methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the methyltransferase complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset [...] (413 aa) |
| | cstf1 | Cleavage stimulation factor, 3' pre-RNA, subunit 1. (431 aa) |
| | strap | Serine/threonine kinase receptor-associated protein. (329 aa) |
| | sema7a | Semaphorin 7A; Belongs to the semaphorin family. (640 aa) |
| | wdr61 | WD repeat-containing protein 61. (305 aa) |
| | ift140 | Intraflagellar transport 140 homolog (Chlamydomonas). (1445 aa) |
| | gnb1a | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). (340 aa) |
| | fbxw10 | F-box and WD repeat domain-containing 10. (731 aa) |
| | fbxw7 | F-box and WD repeat domain-containing 7. (544 aa) |
| | gemin5 | Gem (nuclear organelle)-associated protein 5. (1440 aa) |
| | wdhd1 | WD repeat and HMG-box DNA-binding protein 1. (1112 aa) |
| | Q5RH90_DANRE | Si:dkey-183c2.4. (568 aa) |
| | F1Q5G8_DANRE | Si:dkey-49n23.1; Belongs to the semaphorin family. (758 aa) |
| | wdr6 | WD repeat domain 6. (1193 aa) |
| | fbxw9 | F-box and WD repeat domain-containing 9. (485 aa) |
| | stxbp5a | Syntaxin-binding protein 5a (tomosyn). (1128 aa) |
| | tbl1xr1b | Tbl1x receptor 1b. (510 aa) |
| | dcaf8 | DDB1 and CUL4-associated factor 8. (607 aa) |
| | wdr37 | WD repeat domain 37. (494 aa) |
| | plxnc1 | Plexin C1. (1056 aa) |
| | sema4ba | Semaphorin 4; Belongs to the semaphorin family. (830 aa) |
| | daw1 | Dynein assembly factor with WDR repeat domains 1; Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. (418 aa) |
| | vps8 | VPS8 subunit of CORVET complex. (1412 aa) |
| | ppp2r2ab | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (448 aa) |
| | rbb4l | Histone-binding protein RBBP7; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. (426 aa) |
| | tle2a | TLE family member 2, transcriptional corepressor a. (811 aa) |
| | znf106a | Zinc finger protein 106a. (1636 aa) |
| | mlst8 | Target of rapamycin complex subunit lst8. (326 aa) |
| | tulp4a | TUB-like protein 4a; Belongs to the TUB family. (1736 aa) |
| | pan2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa) |
| | aasdh | Beta-alanine-activating enzyme; Covalently binds beta-alanine in an ATP-dependent manner to form a thioester bond with its phosphopantetheine group and transfers it to an, as yet, unknown acceptor. May be required for a post- translational protein modification or for post-transcriptional modification of an RNA. (1152 aa) |
| | wipi2 | WD repeat domain, phosphoinositide-interacting 2. (425 aa) |
| | sort1b | Sortilin. (828 aa) |
| | hira | Protein HIRA; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1010 aa) |
| | wsb2 | WD repeat and SOCS box-containing 2. (406 aa) |
| | eif2ak3 | Eukaryotic translation initiation factor 2-alpha kinase 3. (1099 aa) |
| | bop1 | Ribosome biogenesis protein bop1; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (785 aa) |
| | sema6d | Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D; Belongs to the semaphorin family. (898 aa) |
| | tecpr2 | Tectonin beta-propeller repeat-containing 2. (1358 aa) |
| | scap | SREBF chaperone. (1245 aa) |
| | nle1 | Notchless homolog 1 (Drosophila). (476 aa) |
| | wdr11 | WD repeat-containing protein 11; Involved in the Hedgehog (Hh) signaling pathway, is essential for normal ciliogenesis. Regulates the proteolytic processing of gli3 and cooperates with the transcription factor emx1 in the induction of downstream Hh pathway gene expression and gonadotropin-releasing hormone production. WDR11 complex facilitates the tethering of Adaptor protein-1 complex (AP-1)-derived vesicles. (1239 aa) |
| | mst1ra | Macrophage-stimulating 1 receptor a. (1350 aa) |
| | met | MET proto-oncogene, receptor tyrosine kinase. (1382 aa) |
| | kif21a | Kinesin family member 21A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1598 aa) |
| | coro2ba | Coronin; Belongs to the WD repeat coronin family. (486 aa) |
| | wdr91 | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport; Belongs to the WD repeat WDR91 family. (727 aa) |
| | wdr45b | WD repeat domain phosphoinositide-interacting protein 3; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. In the cellular response to starvation, may also function in the inhibition of the mTORC1 signaling pathway. Belongs to the WD repeat SVP1 family. (344 aa) |
| | sec31b | SEC31 homolog B, COPII coat complex component. (1171 aa) |
| | bub3 | BUB3 mitotic checkpoint protein. (338 aa) |
| | wdr33 | WD repeat domain 33. (290 aa) |
| | wdr53 | WD repeat domain 53. (372 aa) |
| | ppp2r2aa | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa) |
| | fzr1b | Fizzy/cell division cycle 20-related 1b. (485 aa) |
| | rfwd3 | Ring finger and WD repeat domain 3. (632 aa) |
| | eif3ba | Eukaryotic translation initiation factor 3 subunit B; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome; Belongs to the eIF-3 subunit B family. (681 aa) |
| | nwd1 | NACHT and WD repeat domain-containing 1. (1619 aa) |
| | wdr81 | WD repeat-containing protein 81; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. May also be involved in maintenance of normal mitochondrial structure and organization; Belongs to the WD repeat WDR81 family. (2065 aa) |
| | wdpcp | WD repeat-containing planar cell polarity effector. (707 aa) |
| | sorl1 | Sortilin-related receptor, L(DLR class) A repeats-containing. (2213 aa) |
| | ambra1b | Autophagy/beclin-1 regulator 1b. (1360 aa) |
| | aaas | Achalasia, adrenocortical insufficiency, alacrimia. (499 aa) |
| | plxnb2a | Plexin b2a. (1864 aa) |
| | cpsf1 | Cleavage and polyadenylation-specific factor 1. (1451 aa) |
| | coro6 | Coronin; Belongs to the WD repeat coronin family. (436 aa) |
| | ppp2r2bb | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa) |
| | nbeal1 | Neurobeachin-like 1. (2723 aa) |
| | plxnb1b | Plexin b1b. (2220 aa) |
| | ppp2r2d | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also ma [...] (448 aa) |
| | sort1a | Sortilin; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Belongs to the VPS10-related sortilin family. SORT1 subfamily. (815 aa) |
| | eed | Polycomb protein eed; Polycomb group (PcG) protein. Component of the prc2/eed-ezh2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene (By similarity). (443 aa) |
| | nbeal2 | Neurobeachin-like protein 2; Involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis; Belongs to the WD repeat neurobeachin family. (2788 aa) |
| | rptor | Regulatory-associated protein of MTOR, complex 1. (1363 aa) |
| | WDR63 | WD repeat domain 63. (879 aa) |
| | mios | GATOR complex protein MIOS; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (876 aa) |
| | eif2a | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (580 aa) |
| | gnb1b | Guanine nucleotide binding protein (G protein), beta polypeptide 1, like. (340 aa) |
| | ppp2r2ba | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (439 aa) |
| | sf3b3 | Splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mR [...] (1217 aa) |
| | elp1 | Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1311 aa) |
| | sema6e | Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1064 aa) |
| | SHKBP1 | SH3KBP1 binding protein 1. (841 aa) |
| | sema5a | Semaphorin-5A. (1048 aa) |
| | preb | Prolactin regulatory element-binding. (425 aa) |
| | arhgef10la | Rho guanine nucleotide exchange factor (GEF) 10-like a. (1314 aa) |
| | sema5bb | Semaphorin-5B. (1098 aa) |
| | strn | Striatin, calmodulin-binding protein. (782 aa) |
| | dnai2a | Dynein, axonemal, intermediate chain 2a. (567 aa) |
| | gnb5a | Guanine nucleotide-binding protein subunit beta-5a; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). Along with gnb5b, plays an important role in neuronal [...] (355 aa) |
| | cdc20 | Cell division cycle 20 homolog. (496 aa) |
| | wdr47b | WD repeat domain 47b. (871 aa) |
| | dync1i2b | Dynein, cytoplasmic 1, intermediate chain 2b. (628 aa) |
| | fbxw5 | F-box and WD repeat domain-containing 5. (597 aa) |
| | wdr60 | WD repeat domain 60. (1047 aa) |
| | eml3 | EMAP-like 3. (976 aa) |
| | ENSDARP00000143022 | WD_REPEATS_REGION domain-containing protein. (488 aa) |
| | tle3b | Transducin-like enhancer protein 3-B; Transcriptional corepressor that binds to a number of transcription factors; Belongs to the WD repeat Groucho/TLE family. (771 aa) |
| | fstl5 | Follistatin-like 5. (854 aa) |
| | spag9a | Sperm-associated antigen 9a. (1315 aa) |
| | wdr59 | WD repeat domain 59. (982 aa) |
| | coro1cb | Coronin; Belongs to the WD repeat coronin family. (474 aa) |
| | sema3fb | Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (791 aa) |
| | gnb4b | Guanine nucleotide-binding protein (G protein), beta polypeptide 4b. (340 aa) |
| | rrp9 | Ribosomal RNA-processing 9, U3 small nucleolar RNA-binding protein. (471 aa) |
| | wdr21 | WD repeat domain 21. (503 aa) |
| | wdr45 | WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation; Belongs to the WD repeat SVP1 family. (358 aa) |
| | fbxw11a | F-box and WD repeat domain-containing 11a. (562 aa) |
| | plxna2 | Plexin A2. (1902 aa) |
| | sema5ba | annotation not available (1101 aa) |
| | RIC1 | RIC1 homolog, RAB6A GEF complex partner 1. (1321 aa) |
