STRINGSTRING
rag1 rag1 A3KQE0_DANRE A3KQE0_DANRE mkrn2 mkrn2 rnf175 rnf175 rnf20 rnf20 rnf152 rnf152 rnf10 rnf10 mkrn4 mkrn4 btr02 btr02 trim109 trim109 rnf180 rnf180 btr01 btr01 rnf169 rnf169 trim35-30 trim35-30 traf4b traf4b trim46a trim46a traf2a traf2a traf3 traf3 traf4a traf4a pex2 pex2 rnf8 rnf8 trim46b trim46b shprh shprh toporsb toporsb ENSDARP00000134995 ENSDARP00000134995 uhrf1 uhrf1 LOC100536643 LOC100536643 rnf17 rnf17 rnf170 rnf170
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rag1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1057 aa)
A3KQE0_DANRESi:dkey-29p10.4. (717 aa)
mkrn2Probable E3 ubiquitin-protein ligase makorin-2; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Inhibits neurogenesis and axis formation during embryonic development by modulating the phosphatidylinositol 3-kinase (PI3K) pathway. Acts downstream of PI3K and akt1 to up-regulate gsk3b mRNA expression. (414 aa)
rnf175Ring finger protein 175. (313 aa)
rnf20E3 ubiquitin protein ligase. (1013 aa)
rnf152E3 ubiquitin-protein ligase rnf152; E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation; Belongs to the RNF152 family. (197 aa)
rnf10Ring finger protein 10. (778 aa)
mkrn4Makorin, ring finger protein, 4. (397 aa)
btr02Bloodthirsty-related gene family, member 2. (438 aa)
trim109Tripartite motif-containing 109. (497 aa)
rnf180Ring finger protein 180. (458 aa)
btr01Bloodthirsty-related gene family, member 1. (582 aa)
rnf169E3 ubiquitin-protein ligase RNF169; Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. (630 aa)
trim35-30Tripartite motif-containing 35-30. (470 aa)
traf4bTNF receptor-associated factor. (478 aa)
trim46aTripartite motif-containing 46a. (773 aa)
traf2aTNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (575 aa)
traf3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (573 aa)
traf4aTNF receptor-associated factor. (470 aa)
pex2Peroxisomal biogenesis factor 2. (312 aa)
rnf8E3 ubiquitin-protein ligase rnf8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated mdc1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of tp53 [...] (531 aa)
trim46bTripartite motif-containing 46b. (739 aa)
shprhSNF2 histone linker PHD RING helicase. (1644 aa)
toporsbTopoisomerase I-binding, arginine/serine-rich b. (939 aa)
ENSDARP00000134995Si:ch211-216p19.6. (533 aa)
uhrf1E3 ubiquitin-protein ligase UHRF1; Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits dnmt1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylate [...] (775 aa)
LOC100536643Uncharacterized protein. (466 aa)
rnf17Ring finger protein 17. (1521 aa)
rnf170E3 ubiquitin-protein ligase RNF170; E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor (ITPR) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR turnover in resting cells. (266 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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