STRINGSTRING
myd88 myd88 pik3ap1 pik3ap1 LOC799279 LOC799279 il1rapl1b il1rapl1b ticam1 ticam1 tlr18 tlr18 tlr5b tlr5b tlr5a tlr5a il1rapl1a il1rapl1a tlr20.2 tlr20.2 zmp:0000000936 zmp:0000000936 tlr21 tlr21 tlr4al tlr4al sarm1 sarm1 tlr22 tlr22 sigirr sigirr tlr4bb tlr4bb
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
myd88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and Il-1 receptor signaling pathway in the innate immune response. (284 aa)
pik3ap1Phosphoinositide-3-kinase adaptor protein 1. (837 aa)
LOC799279Uncharacterized protein. (547 aa)
il1rapl1bInterleukin-1 receptor accessory protein-like 1-B; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling. (468 aa)
ticam1Toll-like receptor adaptor molecule 1. (566 aa)
tlr18Toll-like receptor 18. (854 aa)
tlr5bToll-like receptor 5b; Belongs to the Toll-like receptor family. (881 aa)
tlr5aToll-like receptor 5a; Belongs to the Toll-like receptor family. (881 aa)
il1rapl1aInterleukin-1 receptor accessory protein-like 1-A; May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. During presynaptic differentiation may regulate both synaptic vesicle accumulation in axon terminals and subsequent axon terminal remodeling; Belongs to the interleukin-1 receptor family. (744 aa)
tlr20.2Toll-like receptor 20, tandem duplicate 2. (950 aa)
zmp:0000000936Zmp:0000000936. (580 aa)
tlr21Toll-like receptor 21. (989 aa)
tlr4alToll-like receptor 4a, like. (816 aa)
sarm1NAD(+) hydrolase SARM1; NAD(+) hydrolase, which plays a key role in axonal degeneration following injury by regulating NAD(+) metabolism (By similarity). Acts as a negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway by promoting Wallerian degeneration, an injury-induced form of programmed subcellular death which involves degeneration of an axon distal to the injury site (By similarity). Wallerian degeneration is triggerred by NAD(+) depletion: in response to injury, SARM1 is activated and catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR), cyclic ADP [...] (713 aa)
tlr22Toll-like receptor 22; Belongs to the Toll-like receptor family. (955 aa)
sigirrSingle immunoglobulin and toll-interleukin 1 receptor (TIR) domain. (426 aa)
tlr4bbToll-like receptor 4b, duplicate b. (819 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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