STRINGSTRING
hif1aa hif1aa npas4a npas4a epas1b epas1b kcnh4b kcnh4b ncoa3 ncoa3 ncoa2 ncoa2 npas4b npas4b kcnh3 kcnh3 clockb clockb per2 per2 clocka clocka hif1al hif1al arntl2 arntl2 arnt2 arnt2 kcnh4a kcnh4a npas1 npas1 npas4l npas4l NPAS3 NPAS3 sim1b sim1b arntl1a arntl1a hif1ab hif1ab npas2 npas2 epas1a epas1a sim1a sim1a ahr1b ahr1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hif1aaHypoxia-inducible factor 1 subunit alpha a. (717 aa)
npas4aNeuronal PAS domain-containing protein 4A; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal act [...] (933 aa)
epas1bEndothelial PAS domain protein 1b. (834 aa)
kcnh4bPotassium voltage-gated channel, subfamily H (eag-related), member 4b. (1193 aa)
ncoa3Nuclear receptor coactivator 3. (1497 aa)
ncoa2Nuclear receptor coactivator 2; Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (By similarity). Has a role in primitive myelopoiesis in the differentiation of granulocytes and macrophages. May play a role in the positive regulation of the circadian clock (By similarity). (1505 aa)
npas4bNeuronal PAS domain-containing protein 4B; Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus. Plays a key role in the structural and functional plasticity of neurons. Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late- response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal act [...] (538 aa)
kcnh3Potassium voltage-gated channel, subfamily H (eag-related), member 3. (914 aa)
clockbClock circadian regulator b. (820 aa)
per2Period circadian clock 2. (1399 aa)
clockaClock circadian regulator a. (892 aa)
hif1alHypoxia-inducible factor 1 subunit alpha,-like. (626 aa)
arntl2Aryl hydrocarbon receptor nuclear translocator-like 2. (631 aa)
arnt2Aryl hydrocarbon receptor nuclear translocator 2; Transcription factor that plays a role in the development of the hypothalamo-pituitary axis. Specifically recognizes the xenobiotic response element (XRE) (By similarity). Isoform 1 acts as a transcriptional activator. Isoform 3 acts as a transcriptional repressor. (737 aa)
kcnh4aPotassium voltage-gated channel, subfamily H (eag-related), member 4a. (1151 aa)
npas1Neuronal PAS domain protein 1. (770 aa)
npas4lNeuronal PAS domain-containing protein 4-like; Transcription factor specifically expressed in endothelial and hematopoietic precursor cells that acts as a key regulator of the endothelial differentiation cascade. Acts as an early-response transcription factor that regulates the expression of early regulators of endothelial and haematopoietic differentiation, such as etv2 and tal1. (658 aa)
NPAS3Neuronal PAS domain protein 3. (978 aa)
sim1bSIM bHLH transcription factor 1b. (586 aa)
arntl1aAryl hydrocarbon receptor nuclear translocator-like 1a. (626 aa)
hif1abHypoxia-inducible factor 1 subunit alpha b. (777 aa)
npas2BHLH-PAS transcription factor. (845 aa)
epas1aEndothelial PAS domain protein 1a. (842 aa)
sim1aSingle-minded homolog 1-A; Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult. (745 aa)
ahr1bAryl hydrocarbon receptor 1B. (940 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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