(9 nodes) Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily network (Danio rerio)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pik3c2b	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1587 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	prkdc	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4119 aa)
	pi4kb	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). (835 aa)
	smg1	SMG1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans); Belongs to the PI3/PI4-kinase family. (3640 aa)
	pik3c3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (878 aa)
	zgc:158659	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1080 aa)
	pik3ca	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1069 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
atm	pi4kb	ENSDARP00000015167	ENSDARP00000058665	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	0.410
atm	pik3ca	ENSDARP00000015167	ENSDARP00000138914	Non-specific serine/threonine protein kinase.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.443
atm	prkdc	ENSDARP00000015167	ENSDARP00000051678	Non-specific serine/threonine protein kinase.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.712
atm	smg1	ENSDARP00000015167	ENSDARP00000071267	Non-specific serine/threonine protein kinase.	SMG1 homolog phosphatidylinositol 3-kinase-related kinase (C. elegans); Belongs to the PI3/PI4-kinase family.	0.532
pi4kb	atm	ENSDARP00000058665	ENSDARP00000015167	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	Non-specific serine/threonine protein kinase.	0.410
pi4kb	pik3c2b	ENSDARP00000058665	ENSDARP00000110942	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.906
pi4kb	pik3c3	ENSDARP00000058665	ENSDARP00000092039	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.944
pik3c2b	pi4kb	ENSDARP00000110942	ENSDARP00000058665	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	0.906
pik3c2b	pik3c3	ENSDARP00000110942	ENSDARP00000092039	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 3-kinase catalytic subunit type 3.	0.673
pik3c2b	pik3ca	ENSDARP00000110942	ENSDARP00000138914	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.619
pik3c2b	pik3cb	ENSDARP00000110942	ENSDARP00000128403	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.636
pik3c2b	prkdc	ENSDARP00000110942	ENSDARP00000051678	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.421
pik3c2b	zgc:158659	ENSDARP00000110942	ENSDARP00000124781	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.578
pik3c3	pi4kb	ENSDARP00000092039	ENSDARP00000058665	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4-kinase beta; Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP).	0.944
pik3c3	pik3c2b	ENSDARP00000092039	ENSDARP00000110942	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.673
pik3c3	pik3ca	ENSDARP00000092039	ENSDARP00000138914	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.653
pik3c3	pik3cb	ENSDARP00000092039	ENSDARP00000128403	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.639
pik3c3	zgc:158659	ENSDARP00000092039	ENSDARP00000124781	Phosphatidylinositol 3-kinase catalytic subunit type 3.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.639
pik3ca	atm	ENSDARP00000138914	ENSDARP00000015167	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Non-specific serine/threonine protein kinase.	0.443
pik3ca	pik3c2b	ENSDARP00000138914	ENSDARP00000110942	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family.	0.619

page 1 of 2

Server load: low (36%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About