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hspa12a hspa12a actc1c actc1c actr2b actr2b hyou1 hyou1 hspa8 hspa8 gk5 gk5 hspa12b hspa12b osgepl1 osgepl1 zgc:86709 zgc:86709 hspa14 hspa14 hsp70.3 hsp70.3 actr1 actr1 hspa4a hspa4a hsc70 hsc70 hspa8b hspa8b actb1 actb1 hkdc1 hkdc1 actc1a actc1a actr2a actr2a gck gck acta2 acta2 nagk nagk actr8 actr8 actc1b actc1b shpk shpk hsph1 hsph1 hspa4l hspa4l hspa12a.2 hspa12a.2 actl6b actl6b fggy fggy actb2 actb2 osgep osgep pank2 pank2 pank1a pank1a hsp70.1 hsp70.1 hsp70.2 hsp70.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
hspa12aHeat shock protein 12A. (671 aa)
actc1cActin alpha cardiac muscle 1a. (377 aa)
actr2bActin-related protein 2-B; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
hyou1Hypoxia up-regulated protein 1; Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding; Belongs to the heat shock protein 70 family. (980 aa)
hspa8Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (649 aa)
gk5Putative glycerol kinase 5; Belongs to the FGGY kinase family. (529 aa)
hspa12bHeat shock protein 12B. (691 aa)
osgepl1Probable tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (404 aa)
zgc:86709Novel actin protein. (377 aa)
hspa14Heat shock 70 kDa protein 14; Component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding- competent state. (504 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
actr1Actin-related protein 1, centractin. (376 aa)
hspa4aHeat shock protein 4, like. (833 aa)
hsc70Heat shock cognate 70; Belongs to the heat shock protein 70 family. (647 aa)
hspa8bSi:dkey-4p15.3; Belongs to the heat shock protein 70 family. (647 aa)
actb1Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
hkdc1Hexokinase domain-containing 1. (919 aa)
actc1aActin, alpha, cardiac muscle 1a. (377 aa)
actr2aActin-related protein 2-A; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (By similarity). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (By similarity). Seems to contact the pointed end of the daughter actin filament (By similarity). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and [...] (394 aa)
gckPhosphotransferase. (298 aa)
acta2Actin, alpha 2, smooth muscle, aorta. (377 aa)
nagkN-acetylglucosamine kinase. (344 aa)
actr8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize (By similarity); Belongs to the actin family. ARP8 subfamily. (623 aa)
actc1bActin, alpha 1, skeletal muscle. (377 aa)
shpkSedoheptulokinase. (469 aa)
hsph1Heat shock 105/110 protein 1. (901 aa)
hspa4lHeat shock protein 4-like. (826 aa)
hspa12a.2Si:ch211-250m6.2. (571 aa)
actl6bActin-like 6B; Belongs to the actin family. (426 aa)
fggyFGGY carbohydrate kinase domain-containing protein; Belongs to the FGGY kinase family. (396 aa)
actb2Actin, cytoplasmic 2, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
osgepProbable tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity; Belongs to the KAE1 / TsaD family. (335 aa)
pank2Pantothenate kinase 2. (437 aa)
pank1aPantothenate kinase 1a. (373 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
hsp70.2Heat shock cognate 70-kd protein, tandem duplicate 2; Belongs to the heat shock protein 70 family. (643 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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