node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apoeb | cd36 | ENSDARP00000058964 | ENSDARP00000050752 | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | 0.719 |
apoeb | ins | ENSDARP00000058964 | ENSDARP00000051221 | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.717 |
apoeb | insb | ENSDARP00000058964 | ENSDARP00000115146 | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.715 |
apoeb | pparg | ENSDARP00000058964 | ENSDARP00000142487 | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.674 |
apoeb | tnfb | ENSDARP00000058964 | ENSDARP00000010728 | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.728 |
arntl1a | insb | ENSDARP00000004223 | ENSDARP00000115146 | Aryl hydrocarbon receptor nuclear translocator-like 1a. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.407 |
arntl1a | nr1d1 | ENSDARP00000004223 | ENSDARP00000104933 | Aryl hydrocarbon receptor nuclear translocator-like 1a. | Nuclear receptor subfamily 1, group d, member 1. | 0.981 |
arntl1a | pparg | ENSDARP00000004223 | ENSDARP00000142487 | Aryl hydrocarbon receptor nuclear translocator-like 1a. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.521 |
cd36 | apoeb | ENSDARP00000050752 | ENSDARP00000058964 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Apolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. | 0.719 |
cd36 | fabp3 | ENSDARP00000050752 | ENSDARP00000039143 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Fatty acid-binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | 0.570 |
cd36 | ins | ENSDARP00000050752 | ENSDARP00000051221 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.667 |
cd36 | insb | ENSDARP00000050752 | ENSDARP00000115146 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.594 |
cd36 | pparg | ENSDARP00000050752 | ENSDARP00000142487 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.844 |
cd36 | tnfb | ENSDARP00000050752 | ENSDARP00000010728 | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.655 |
fabp3 | cd36 | ENSDARP00000039143 | ENSDARP00000050752 | Fatty acid-binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. | 0.570 |
fabp3 | pparg | ENSDARP00000039143 | ENSDARP00000142487 | Fatty acid-binding protein 3, muscle and heart; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.450 |
gsk3ba | ins | ENSDARP00000027785 | ENSDARP00000051221 | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.791 |
gsk3ba | insb | ENSDARP00000027785 | ENSDARP00000115146 | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.790 |
gsk3ba | pparg | ENSDARP00000027785 | ENSDARP00000142487 | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.581 |
gsk3ba | tnfb | ENSDARP00000027785 | ENSDARP00000010728 | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.577 |