STRINGSTRING
ube2ib ube2ib wnk1b wnk1b egr1 egr1 sumo3b sumo3b camk2a camk2a ucp1 ucp1 sgk1 sgk1 atf3 atf3 hsp90aa1.1 hsp90aa1.1 hsp70.3 hsp70.3 ell ell adamts1 adamts1 sumo2a sumo2a nr3c2 nr3c2 grem2b grem2b rgs2 rgs2 egfra egfra ncor1 ncor1 g6pd g6pd pgr pgr hsp70.1 hsp70.1 ace2 ace2 ace ace edn1 edn1 kat2b kat2b serpine1 serpine1 mdm2 mdm2 pomca pomca ren ren acta1b acta1b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ube2ibSUMO-conjugating enzyme UBC9-A; Accepts the ubiquitin-like proteins sumo1, sumo2 and sumo3 from the uble1a-uble1b E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as ranbp2 or cbx4. Essential for nuclear architecture and chromosome segregation (By similarity). Mediates nuclear localization of vsx1. Required for progression through mitosis during organogenesis. Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
wnk1bWNK lysine deficient protein kinase 1b. (2357 aa)
egr1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (511 aa)
sumo3bSmall ubiquitin-related modifier. (94 aa)
camk2aCalcium/calmodulin-dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (478 aa)
ucp1Uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
sgk1Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity); Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (433 aa)
atf3Activating transcription factor 3. (202 aa)
hsp90aa1.1Heat shock protein HSP 90-alpha 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a [...] (725 aa)
hsp70.3Heat shock cognate 70-kd protein, tandem duplicate 3; Belongs to the heat shock protein 70 family. (643 aa)
ellElongation factor RNA polymerase II. (660 aa)
adamts1ADAM metallopeptidase with thrombospondin type 1 motif, 1. (911 aa)
sumo2aSmall ubiquitin-related modifier. (94 aa)
nr3c2Nuclear receptor subfamily 3, group C, member 2. (970 aa)
grem2bGremlin. (166 aa)
rgs2Regulator of G protein-signaling 2. (199 aa)
egfraEpidermal growth factor receptor precursor. (625 aa)
ncor1Nuclear receptor corepressor 1. (2398 aa)
g6pdGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (523 aa)
pgrProgesterone receptor. (553 aa)
hsp70.1Heat shock cognate 70-kd protein, tandem duplicate 1; Belongs to the heat shock protein 70 family. (643 aa)
ace2Angiotensin-converting enzyme. (818 aa)
aceAngiotensin-converting enzyme. (1324 aa)
edn1Endothelin 1. (188 aa)
kat2bHistone acetyltransferase KAT2B; Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (By similarity). Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (By similarity). Also acetylates non- histone proteins. Involved in heart and limb development by mediating acetylation of tbx5. Also acetylates spermidine (By similarity). Together with kat2a, required for growth and differentiation of craniofacial cartilage and bone by regulating acetylation of histone H3 at 'Lys-9' (H3K9ac) ; Bel [...] (796 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (392 aa)
mdm2E3 ubiquitin-protein ligase Mdm2; E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. (475 aa)
pomcaPro-opiomelanocortin protein. (222 aa)
renRenin; Belongs to the peptidase A1 family. (395 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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