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fdx1 fdx1 alas1 alas1 mb mb ISCU ISCU sdhb sdhb glrx5 glrx5 ciao1 ciao1 abcb7 abcb7 brip1 brip1 lyrm4 lyrm4 ercc2 ercc2 nfu1 nfu1 fxn fxn ireb2 ireb2 SDHB SDHB tfr1b tfr1b fech fech nubp1 nubp1 tfr1a tfr1a fdxr fdxr
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fdx1Ferredoxin 1. (175 aa)
alas15-aminolevulinate synthase. (621 aa)
mbMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
ISCUSi:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (165 aa)
sdhbSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
glrx5Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis. (155 aa)
ciao1Probable cytosolic iron-sulfur protein assembly protein ciao1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family. (330 aa)
abcb7ATP-binding cassette, sub-family B (MDR/TAP), member 7. (743 aa)
brip1BRCA1-interacting protein C-terminal helicase 1. (1216 aa)
lyrm4LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. (89 aa)
ercc2Excision repair cross-complementation group 2. (760 aa)
nfu1NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). (243 aa)
fxnFrataxin. (200 aa)
ireb2Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. (974 aa)
SDHBSi:dkey-31b16.7. (185 aa)
tfr1bTransferrin receptor 1b. (771 aa)
fechFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. (409 aa)
nubp1Cytosolic Fe-S cluster assembly factor nubp1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (321 aa)
tfr1aTransferrin receptor 1a. (770 aa)
fdxrNADPH:adrenodoxin oxidoreductase, mitochondrial. (486 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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