node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ISCU | SDHB | ENSDARP00000051606 | ENSDARP00000118231 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Si:dkey-31b16.7. | 0.710 |
ISCU | abcb7 | ENSDARP00000051606 | ENSDARP00000085602 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | ATP-binding cassette, sub-family B (MDR/TAP), member 7. | 0.870 |
ISCU | ciao1 | ENSDARP00000051606 | ENSDARP00000076693 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Probable cytosolic iron-sulfur protein assembly protein ciao1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Belongs to the WD repeat CIA1 family. | 0.546 |
ISCU | fdx1 | ENSDARP00000051606 | ENSDARP00000113657 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Ferredoxin 1. | 0.965 |
ISCU | fdxr | ENSDARP00000051606 | ENSDARP00000149109 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NADPH:adrenodoxin oxidoreductase, mitochondrial. | 0.889 |
ISCU | fech | ENSDARP00000051606 | ENSDARP00000125028 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.868 |
ISCU | fxn | ENSDARP00000051606 | ENSDARP00000115873 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Frataxin. | 0.998 |
ISCU | glrx5 | ENSDARP00000051606 | ENSDARP00000064111 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Glutaredoxin-related protein 5, mitochondrial; Monothiol glutaredoxin involved in iron-sulfur biogenesis. Required for normal iron homeostasis. Required for normal hemoglobin biosynthesis. | 0.883 |
ISCU | ireb2 | ENSDARP00000051606 | ENSDARP00000117448 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Iron-responsive element-binding protein 2; Belongs to the aconitase/IPM isomerase family. | 0.776 |
ISCU | lyrm4 | ENSDARP00000051606 | ENSDARP00000103510 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis. | 0.989 |
ISCU | mb | ENSDARP00000051606 | ENSDARP00000039806 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | 0.460 |
ISCU | nfu1 | ENSDARP00000051606 | ENSDARP00000114381 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae). | 0.959 |
ISCU | nubp1 | ENSDARP00000051606 | ENSDARP00000129550 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Cytosolic Fe-S cluster assembly factor nubp1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The nubp1-nubp2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. | 0.576 |
ISCU | sdhb | ENSDARP00000051606 | ENSDARP00000062263 | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.716 |
SDHB | ISCU | ENSDARP00000118231 | ENSDARP00000051606 | Si:dkey-31b16.7. | Si:ch211-191d15.2; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.710 |
SDHB | alas1 | ENSDARP00000118231 | ENSDARP00000005771 | Si:dkey-31b16.7. | 5-aminolevulinate synthase. | 0.409 |
SDHB | fdx1 | ENSDARP00000118231 | ENSDARP00000113657 | Si:dkey-31b16.7. | Ferredoxin 1. | 0.413 |
SDHB | fdxr | ENSDARP00000118231 | ENSDARP00000149109 | Si:dkey-31b16.7. | NADPH:adrenodoxin oxidoreductase, mitochondrial. | 0.518 |
SDHB | fech | ENSDARP00000118231 | ENSDARP00000125028 | Si:dkey-31b16.7. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.636 |
SDHB | fxn | ENSDARP00000118231 | ENSDARP00000115873 | Si:dkey-31b16.7. | Frataxin. | 0.704 |