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tpma tpma tbxta tbxta smyhc1 smyhc1 pax7a pax7a tnnt3b tnnt3b myf5 myf5 myhz2 myhz2 ttn.1 ttn.1 myhz1.1 myhz1.1 erbb3b erbb3b tnnc2 tnnc2 ctrl ctrl mef2ca mef2ca mybpc1 mybpc1 myod1 myod1 myog myog fgf8a fgf8a lbx2 lbx2 pax3a pax3a tnnt2c tnnt2c acta1b acta1b mylpfa mylpfa prox1a prox1a tnnt1 tnnt1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tpmaTropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (284 aa)
tbxtaT-box transcription factor T-A; Involved in the transcriptional regulation of genes required for mesoderm differentiation, including itself. Indispensable for the formation of the notochord and the tail structure. Functions together with tbx16/spadetail in development of trunk and tail mesoderm. Functions by itself early in development to repress medial floor plate and promote notochord fate but at later times, functions together with tbx16/spadetail to promote medial floor plate formation. Acts in a parallel pathway to, but cooperates with, non-canonical wnt-signaling during tail form [...] (423 aa)
smyhc1Slow myosin heavy chain 1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1938 aa)
pax7aTranscription factor PAX7C. (507 aa)
tnnt3bTroponin T type 3b (skeletal, fast). (284 aa)
myf5Myogenic factor. (237 aa)
myhz2Myosin, heavy polypeptide 2, fast muscle-specific; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
erbb3bErb-b2 receptor tyrosine kinase 3b. (1429 aa)
tnnc2Fast skeletal muscle troponin C. (160 aa)
ctrlChymotrypsin-like; Belongs to the peptidase S1 family. (261 aa)
mef2caMyocyte enhancer factor 2ca. (465 aa)
mybpc1Myosin-binding protein C1. (1167 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myogMyogenin. (256 aa)
fgf8aFibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration (By similarity). Required for Kupffer's vesicle ciliogenesis. (210 aa)
lbx2Ladybird homeobox homolog 2 (Drosophila). (257 aa)
pax3aTranscription factor PAX3. (509 aa)
tnnt2cTroponin T1, skeletal, slow. (290 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
prox1aProspero homeobox 1a. (739 aa)
tnnt1Troponin T type 1 (skeletal, slow). (342 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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