(46 nodes) (2009) MicroRNAs as novel regulators of angiogenesis. network (Danio rerio)

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	epha3	Ephrin type-A receptor 3. (963 aa)
	flt1	Vascular endothelial growth factor receptor 1 isoform 1 precursor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1272 aa)
	tnfb	Tumor necrosis factor b (TNF superfamily, member 2). (242 aa)
	epha2a	Eph receptor A2 a. (984 aa)
	efna3a	Ephrin-A3a; Belongs to the ephrin family. (220 aa)
	epha4b	Eph receptor A4b. (976 aa)
	cdkn1ba	Cyclin-dependent kinase inhibitor 1Ba. (187 aa)
	kdr	Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1357 aa)
	ncf1	Neutrophil cytosolic factor 1. (410 aa)
	tek	Tyrosine-protein kinase receptor Tie-2; Tyrosine-protein kinase that acts as cell-surface receptor for angiopoietins and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Can activate or inhibit angiogenesis, depending on the context. Angiopoietin signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors (By similarity). (1116 aa)
	spred1	Sprouty-related EVH1 domain-containing 1. (391 aa)
	ren	Renin; Belongs to the peptidase A1 family. (395 aa)
	ccn2a	Novel protein similar to vertebrate connective tissue growth factor (CTGF). (345 aa)
	angpt2b	Angiopoietin 2b. (489 aa)
	hoxb5b	Homeobox protein Hox-B5b; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (276 aa)
	cdkn1bb	Cyclin-dependent kinase inhibitor 1b (P27, kip1). (179 aa)
	crk	V-crk sarcoma virus CT10 oncogene homolog (Avian). (311 aa)
	ptenb	Phosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (422 aa)
	ago2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (873 aa)
	drosha	Drosha ribonuclease III. (1289 aa)
	itga6b	Integrin, alpha 6b; Belongs to the integrin alpha chain family. (1085 aa)
	ek1	Ephrin type-A receptor 3; Receptor tyrosine kinase which binds promiscuously membrane- bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially efna5. Upon activation by efna5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in ca [...] (981 aa)
	bcl2l11	BCL2-like 11. (176 aa)
	itga6a	Integrin, alpha 6a; Belongs to the integrin alpha chain family. (1092 aa)
	kita	Mast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
	myca	Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
	e2f3	E2F transcription factor 3. (429 aa)
	dgcr8	DGCR8 microprocessor complex subunit. (782 aa)
	thbs1b	Thrombospondin 1b. (1171 aa)
	bcl2a	B-cell leukemia/lymphoma 2. (228 aa)
	hgs	Hepatocyte growth factor-regulated tyrosine kinase substrate. (757 aa)
	angptl4	Angiopoietin-like 4. (491 aa)
	met	MET proto-oncogene, receptor tyrosine kinase. (1382 aa)
	itga6l	Integrin, alpha 6,-like; Belongs to the integrin alpha chain family. (1035 aa)
	ago1	Argonaute RISC component 1; Belongs to the argonaute family. (858 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (724 aa)
	ccn2b	Connective tissue growth factor-like protein. (351 aa)
	efna3b	Ephrin-A3b; Belongs to the ephrin family. (219 aa)
	kdrl	Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. (1301 aa)
	XPO5	Si:ch211-233m11.2. (906 aa)
	e2f1	E2F transcription factor 1. (429 aa)
	angpt2a	Angiopoietin 2a. (488 aa)
	vcam1b	Vascular cell adhesion molecule 1b. (808 aa)
	tie1	Tyrosine-protein kinase receptor Tie-1; Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. (1150 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	thbs1a	Thrombospondin 1a. (795 aa)

Your Current Organism:

Danio rerio

NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XPO5	ago1	ENSDARP00000136252	ENSDARP00000129194	Si:ch211-233m11.2.	Argonaute RISC component 1; Belongs to the argonaute family.	0.875
XPO5	ago2	ENSDARP00000136252	ENSDARP00000081621	Si:ch211-233m11.2.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.949
XPO5	bcl2l11	ENSDARP00000136252	ENSDARP00000097551	Si:ch211-233m11.2.	BCL2-like 11.	0.408
XPO5	dgcr8	ENSDARP00000136252	ENSDARP00000113375	Si:ch211-233m11.2.	DGCR8 microprocessor complex subunit.	0.999
XPO5	drosha	ENSDARP00000136252	ENSDARP00000083450	Si:ch211-233m11.2.	Drosha ribonuclease III.	0.999
XPO5	myca	ENSDARP00000136252	ENSDARP00000100455	Si:ch211-233m11.2.	Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.413
XPO5	ptenb	ENSDARP00000136252	ENSDARP00000073594	Si:ch211-233m11.2.	Phosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.580
XPO5	spred1	ENSDARP00000136252	ENSDARP00000060763	Si:ch211-233m11.2.	Sprouty-related EVH1 domain-containing 1.	0.425
ago1	XPO5	ENSDARP00000129194	ENSDARP00000136252	Argonaute RISC component 1; Belongs to the argonaute family.	Si:ch211-233m11.2.	0.875
ago1	ago2	ENSDARP00000129194	ENSDARP00000081621	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.949
ago1	dgcr8	ENSDARP00000129194	ENSDARP00000113375	Argonaute RISC component 1; Belongs to the argonaute family.	DGCR8 microprocessor complex subunit.	0.879
ago1	drosha	ENSDARP00000129194	ENSDARP00000083450	Argonaute RISC component 1; Belongs to the argonaute family.	Drosha ribonuclease III.	0.949
ago2	XPO5	ENSDARP00000081621	ENSDARP00000136252	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Si:ch211-233m11.2.	0.949
ago2	ago1	ENSDARP00000081621	ENSDARP00000129194	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.949
ago2	bcl2a	ENSDARP00000081621	ENSDARP00000120749	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	B-cell leukemia/lymphoma 2.	0.417
ago2	dgcr8	ENSDARP00000081621	ENSDARP00000113375	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	DGCR8 microprocessor complex subunit.	0.924
ago2	drosha	ENSDARP00000081621	ENSDARP00000083450	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Drosha ribonuclease III.	0.982
ago2	e2f1	ENSDARP00000081621	ENSDARP00000137549	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	E2F transcription factor 1.	0.430
ago2	myca	ENSDARP00000081621	ENSDARP00000100455	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.482
ago2	ptenb	ENSDARP00000081621	ENSDARP00000073594	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Phosphatase and tensin homolog B; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.596

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