STRINGSTRING
tmem59 tmem59 ush1c ush1c CYTB CYTB ATP6 ATP6 fzd3a fzd3a sympk sympk ehd4 ehd4 twf1b twf1b twf2b twf2b cdh23 cdh23 acta1b acta1b gdf5 gdf5 twf2 twf2 calm2a calm2a otos otos pcdh15b pcdh15b pxdn pxdn pcdh15a pcdh15a pvalb7 pvalb7 fzd3b fzd3b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tmem59Si:dkey-181m9.10 protein. (329 aa)
ush1cUsher syndrome 1C (Autosomal recessive, severe). (548 aa)
CYTBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis. (380 aa)
ATP6ATP synthase subunit a; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subuni [...] (227 aa)
fzd3aTransmembrane receptor frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (685 aa)
sympkSymplekin. (1248 aa)
ehd4EH-domain-containing 4; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (614 aa)
twf1bTwinfilin, actin-binding protein, homolog 1b. (349 aa)
twf2bTwinfilin actin-binding protein 2b. (364 aa)
cdh23Cadherin-related 23. (2883 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
gdf5Growth differentiation factor 5. (474 aa)
twf2Twinfilin-2; Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G- actin (By similarity). (347 aa)
calm2aCalmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (149 aa)
otosOtospiralin. (90 aa)
pcdh15bProtocadherin-related 15b. (1907 aa)
pxdnPeroxidasin. (1460 aa)
pcdh15aProtocadherin-related 15a. (1796 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
fzd3bFrizzled class receptor 3b; Belongs to the G-protein coupled receptor Fz/Smo family. (667 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
Server load: low (14%) [HD]