node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dll4 | gapdh | ENSDARP00000094097 | ENSDARP00000063799 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.493 |
dll4 | gapdhs | ENSDARP00000094097 | ENSDARP00000058383 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Glyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. | 0.512 |
dll4 | jag1b | ENSDARP00000094097 | ENSDARP00000008197 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Protein jagged-1b; Ligand for Notch receptors and involved in the mediation of Notch signaling (By similarity). Seems to be involved in cell-fate decisions. | 0.401 |
dll4 | kdr | ENSDARP00000094097 | ENSDARP00000049203 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Vascular endothelial growth factor receptor 2; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.871 |
dll4 | kdrl | ENSDARP00000094097 | ENSDARP00000134625 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Vascular endothelial growth factor receptor kdr-like; Receptor for VEGF or VEGFC. Has a tyrosine-protein kinase activity. Combinations of multiple VEGF receptors are required for development of different blood vessel types in the embryo. Involved in angiogenesis, specifically in VEGF-induced sprouting of new blood vessels. Particularly involved in artery formation. Does not appear to be required for hematopoiesis. | 0.939 |
dll4 | notch1a | ENSDARP00000094097 | ENSDARP00000137942 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.990 |
dll4 | notch1b | ENSDARP00000094097 | ENSDARP00000050854 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Notch receptor 1b. | 0.949 |
dll4 | pdgfba | ENSDARP00000094097 | ENSDARP00000146148 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. | 0.753 |
dll4 | vegfaa | ENSDARP00000094097 | ENSDARP00000133415 | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | Vascular endothelial growth factor A-A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis, and induces permeabilization of blood vessels. Acts both upstream of kdr and tie1 to stimulate endothelial cell differentiation, and upstream of gata1 to stimulate hematopoietic cell differentiation. | 0.749 |
elk4 | gapdh | ENSDARP00000093624 | ENSDARP00000063799 | ETS transcription factor ELK4. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.406 |
elk4 | gapdhs | ENSDARP00000093624 | ENSDARP00000058383 | ETS transcription factor ELK4. | Glyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. | 0.403 |
elk4 | jun | ENSDARP00000093624 | ENSDARP00000063911 | ETS transcription factor ELK4. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.410 |
elk4 | notch1a | ENSDARP00000093624 | ENSDARP00000137942 | ETS transcription factor ELK4. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.575 |
fosab | gapdh | ENSDARP00000043297 | ENSDARP00000063799 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | 0.520 |
fosab | gapdhs | ENSDARP00000043297 | ENSDARP00000058383 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Glyceraldehyde-3-phosphate dehydrogenase 2; Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. | 0.484 |
fosab | jun | ENSDARP00000043297 | ENSDARP00000063911 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. | 0.999 |
fosab | notch1a | ENSDARP00000043297 | ENSDARP00000137942 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Neurogenic locus notch homolog protein 1; Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the [...] | 0.518 |
fosab | rel | ENSDARP00000043297 | ENSDARP00000072078 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | V-rel avian reticuloendotheliosis viral oncogene homolog. | 0.419 |
fosab | tnfb | ENSDARP00000043297 | ENSDARP00000010728 | V-fos FBJ murine osteosarcoma viral oncogene homolog Ab. | Tumor necrosis factor b (TNF superfamily, member 2). | 0.562 |
gapdh | dll4 | ENSDARP00000063799 | ENSDARP00000094097 | Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] | Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. | 0.493 |