STRINGSTRING
foxd3 foxd3 tyrp1a tyrp1a mitfa mitfa gcga gcga pou5f3 pou5f3 snai1b snai1b tyrp1b tyrp1b kita kita hdac5 hdac5 sox10 sox10 dct dct nrl nrl hdac4 hdac4 fgf2 fgf2 bcl2a bcl2a tyr tyr agt agt foxl1 foxl1 pax3a pax3a
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
foxd3Forkhead box D3. (371 aa)
tyrp1aTyrosinase-related protein 1a. (524 aa)
mitfaMicrophthalmia-associated transcription factor a. (412 aa)
gcgaGlucagon a. (121 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
snai1bSnail family zinc finger 1b. (256 aa)
tyrp1bTyrosinase-related protein 1b. (526 aa)
kitaMast/stem cell growth factor receptor kita; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine kitlg/scf and plays a role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, and in mast cell development, migration and function. Required for the migration of cells in the melanocyte lineage and the survival of embryonic melanocytes. Required for the differentiation of some, but not all, melanocytes. Not essential for hematopoiesis or primordial germ cell development. (981 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
sox10HMG-box transcription factor Sox10. (485 aa)
dctDopachrome tautomerase. (513 aa)
nrlLeucine zipper transcription factor. (412 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (154 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
tyrTyrosinase. (535 aa)
agtAngiotensinogen; Belongs to the serpin family. (454 aa)
foxl1Forkhead transcription factor. (360 aa)
pax3aTranscription factor PAX3. (509 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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