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vangl2 | Vang-like protein 2; Plays a role in non-canonical Wnt/planar cell polarity (PCP) signaling to regulate convergent extension cell movements during gastrulation. Acts together with scrib and prickle1 and localizes prickle1 and dvl2/dsh to the plasma membrane. Has an overlapping role with kny during both convergent extension and eye development. In the eye, involved in establishing proper alignment of the anterior neural plate and midline cells expressing shha and shhb/twhh. Has indirect effects on a number of other developmental processes including notochord shape formation, neural prog [...] (526 aa) | ||||
gli2a | GLI family zinc finger 2a. (1439 aa) | ||||
smo | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (822 aa) | ||||
invs | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. (1025 aa) | ||||
rhoab | Rho-related GTP-binding protein RhoA-B; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. (193 aa) | ||||
ptch1 | Protein patched homolog 1. (1475 aa) | ||||
stat6 | Signal transducer and activator of transcription. (758 aa) | ||||
pkd2 | Polycystin-2; Component of a heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. Can also form a functional, homotetrameric ion channel (By similarity). Functions as non-selective, voltage-gated cation channel (By similarity). Required for normal oscillation of Ca(2+) levels within cilia; these oscillations of the intraciliary Ca(2+) levels can trigger cytoplasmic Ca(2+) signaling cascades. May contribute to the release of Ca(2+) stores from the endoplasmic reticulum (By simila [...] (904 aa) | ||||
gsk3ba | Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa) | ||||
sparc | Secreted protein, acidic, cysteine-rich (osteonectin). (291 aa) | ||||
tle3a | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. (776 aa) | ||||
acta1b | Actin alpha 1, skeletal muscle b. (377 aa) | ||||
gli3 | GLI family zinc finger 3. (1553 aa) | ||||
pomca | Pro-opiomelanocortin protein. (222 aa) | ||||
gsk3bb | Glycogen synthase kinase 3 beta, genome duplicate b; Belongs to the protein kinase superfamily. (419 aa) | ||||
fzd2 | Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (550 aa) | ||||
ptch2 | Protein patched homolog 1; Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal (By similarity). Belongs to the patched family. (1442 aa) | ||||
lepr | Leptin receptor. (1065 aa) | ||||
pomcb | Proopiomelanocortin b. (215 aa) | ||||
kif3a | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (701 aa) | ||||
ENSDARP00000125042 | Patched 1. (120 aa) | ||||
mchr1a | Melanin-concentrating hormone receptor 1a. (322 aa) | ||||
sufu | Suppressor of fused homolog. (485 aa) | ||||
axin1 | Axin-1; Component of the beta-catenin destruction complex required for regulating ctnnb1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects: down- regulates ctnnb1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (835 aa) | ||||
ctnnb1 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa) | ||||
fat4 | FAT atypical cadherin 4. (4531 aa) | ||||
mchr1b | Melanin-concentrating hormone receptor 1b. (364 aa) | ||||
dub | Duboraya. (305 aa) |