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fstl1b | Follistatin-like 1b. (310 aa) | ||||
chrdl2 | Chordin-like protein. (454 aa) | ||||
gata2a | GATA-binding protein 2a. (456 aa) | ||||
nog1 | Noggin-1; Inhibitor of bone morphogenetic proteins (BMP) signaling. May play an important role in the dorsoventral patterning of the embryo; Belongs to the noggin family. (216 aa) | ||||
fstb | Follistatin 2. (344 aa) | ||||
bmp4 | Bone morphogenetic protein 4. (400 aa) | ||||
gdf11 | Growth differentiation factor 11. (390 aa) | ||||
tll1 | Dorsal-ventral patterning tolloid-like protein 1; Required for patterning ventral tissues of the tail. May increase bone morphogenetic protein (BMP) activity at the end of gastrulation by proteolytic cleavage of chordin and release of BMP from inactive complexes. (1022 aa) | ||||
bmp7a | Bone morphogenetic protein 7a. (432 aa) | ||||
gdf5 | Growth differentiation factor 5. (474 aa) | ||||
fsta | Follistatin-A; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh) (By similarity). Inhibits bmp-signaling during later stages of development including late phases of dorsoventral patterning, to refine the early pattern set up by the interaction of chordino and bmp2/4. Not involved in organizer function or early phases of dorsoventral pattern formation. (324 aa) | ||||
tp53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa) |