node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acta1b | bmp7a | ENSDARP00000058628 | ENSDARP00000017352 | Actin alpha 1, skeletal muscle b. | Bone morphogenetic protein 7a. | 0.451 |
acta1b | myca | ENSDARP00000058628 | ENSDARP00000100455 | Actin alpha 1, skeletal muscle b. | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.823 |
acta1b | myf5 | ENSDARP00000058628 | ENSDARP00000109289 | Actin alpha 1, skeletal muscle b. | Myogenic factor. | 0.566 |
acta1b | shha | ENSDARP00000058628 | ENSDARP00000125090 | Actin alpha 1, skeletal muscle b. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.683 |
acta1b | shhb | ENSDARP00000058628 | ENSDARP00000056746 | Actin alpha 1, skeletal muscle b. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.578 |
bmp7a | acta1b | ENSDARP00000017352 | ENSDARP00000058628 | Bone morphogenetic protein 7a. | Actin alpha 1, skeletal muscle b. | 0.451 |
bmp7a | chrd | ENSDARP00000017352 | ENSDARP00000045109 | Bone morphogenetic protein 7a. | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | 0.994 |
bmp7a | gsc | ENSDARP00000017352 | ENSDARP00000076522 | Bone morphogenetic protein 7a. | Homeobox protein goosecoid. | 0.494 |
bmp7a | shha | ENSDARP00000017352 | ENSDARP00000125090 | Bone morphogenetic protein 7a. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.771 |
bmp7a | shhb | ENSDARP00000017352 | ENSDARP00000056746 | Bone morphogenetic protein 7a. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.615 |
chrd | bmp7a | ENSDARP00000045109 | ENSDARP00000017352 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Bone morphogenetic protein 7a. | 0.994 |
chrd | gsc | ENSDARP00000045109 | ENSDARP00000076522 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Homeobox protein goosecoid. | 0.961 |
chrd | lft1 | ENSDARP00000045109 | ENSDARP00000005312 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Left-right determination factor; Belongs to the TGF-beta family. | 0.745 |
chrd | ndr1 | ENSDARP00000045109 | ENSDARP00000074144 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Nodal-related 1. | 0.807 |
chrd | shha | ENSDARP00000045109 | ENSDARP00000125090 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.697 |
chrd | shhb | ENSDARP00000045109 | ENSDARP00000056746 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Tiggy-winkle hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Involved in dorso-ventral patterning of the brain and in early patterning of the developing eyes. | 0.518 |
chrd | tdgf1 | ENSDARP00000045109 | ENSDARP00000042440 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity); Belongs to the chordin family. | Teratocarcinoma-derived growth factor 1. | 0.724 |
foxd3 | myca | ENSDARP00000107660 | ENSDARP00000100455 | Forkhead box D3. | Transcriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. | 0.502 |
foxd3 | shha | ENSDARP00000107660 | ENSDARP00000125090 | Forkhead box D3. | Sonic hedgehog protein A N-product; Sonic hedgehog protein: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). | 0.517 |
foxd3 | tle3a | ENSDARP00000107660 | ENSDARP00000045678 | Forkhead box D3. | Transducin-like enhancer protein 3-A; Transcriptional corepressor that binds to a number of transcription factors. Enhances the transcriptional repression activity of pnx; Belongs to the WD repeat Groucho/TLE family. | 0.445 |