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apoeb apoeb usf1 usf1 esrrga esrrga cnr1 cnr1 nr2e1 nr2e1 insig1 insig1 nr6a1b nr6a1b stat5a stat5a slc10a2 slc10a2 cav3 cav3 cycsb cycsb nr2f5 nr2f5 glb1l glb1l abcb11a abcb11a nos2b nos2b cd36 cd36 ins ins bag3 bag3 nr1h4 nr1h4 mmp9 mmp9 nr4a2b nr4a2b pou5f3 pou5f3 pax2a pax2a nr4a3 nr4a3 esr1 esr1 abcg5 abcg5 srebf1 srebf1 abcg1 abcg1 hmgcra hmgcra sirt1 sirt1 cyp8b1 cyp8b1 abcb11b abcb11b hdac5 hdac5 nr4a2a nr4a2a myca myca abcg8 abcg8 birc2 birc2 nr1d1 nr1d1 nr0b1 nr0b1 nr1i2 nr1i2 glb1 glb1 nos2a nos2a nr2f2 nr2f2 nr2e3 nr2e3 cyp19a1a cyp19a1a insb insb tp53 tp53 nr2f1a nr2f1a A2BIK1_DANRE A2BIK1_DANRE ncor1 ncor1 bcl2a bcl2a nr2c1 nr2c1 abca1a abca1a hmgcrb hmgcrb nos1 nos1 hdac4 hdac4 ctnnb1 ctnnb1 nr1h3 nr1h3 ccnd1 ccnd1 nr5a2 nr5a2 esrra esrra esrrb esrrb nr6a1a nr6a1a
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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apoebApolipoprotein Eb; APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. Belongs to the apolipoprotein A1/A4/E family. (281 aa)
usf1Upstream transcription factor 1. (309 aa)
esrrgaEstrogen-related receptor gamma a. (501 aa)
cnr1Cannabinoid receptor; Involved in cannabinoid-induced CNS effects. Belongs to the G-protein coupled receptor 1 family. (475 aa)
nr2e1Nuclear receptor subfamily 2, group E, member 1. (396 aa)
insig1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (251 aa)
nr6a1bNuclear receptor subfamily 6 group A member 1-B; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity). (455 aa)
stat5aSignal transducer and activator of transcription. (785 aa)
slc10a2Solute carrier family 10 (Sodium/bile acid cotransporter family), member 2. (361 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (150 aa)
cycsbCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (104 aa)
nr2f5Nuclear receptor subfamily 2 group F member 5; Putative receptor that is required in photoreceptor cells precursors during eye development; Belongs to the nuclear hormone receptor family. NR2 subfamily. (403 aa)
glb1lGalactosidase, beta 1-like; Belongs to the glycosyl hydrolase 35 family. (629 aa)
abcb11aATP-binding cassette, sub-family B (MDR/TAP), member 11a. (1320 aa)
nos2bNitric oxide synthase; Produces nitric oxide (NO). (1077 aa)
cd36CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (465 aa)
insInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (108 aa)
bag3BCL2-associated athanogene 3. (480 aa)
nr1h4Nuclear receptor subfamily 1, group H, member 4. (483 aa)
mmp9Matrix metallopeptidase 9. (680 aa)
nr4a2bNuclear receptor subfamily 4, group A, member 2b. (586 aa)
pou5f3POU domain, class 5, transcription factor 1; Involved in early development of embryos, especially in the process of gastrulation. May play an important role in establishing and specifying rhombomeric segments. Seems to be required to maintain the cells in a highly undifferentiated state. In contrast to POU2, T-POU2 lacks DNA-binding activity because of its incomplete pou domain structure. Overexpression of POU2 does not have any effect on development, whereas overexpression of t-POU2 causes developmental retardation or arrest before gastrulation; Belongs to the POU transcription factor [...] (472 aa)
pax2aPaired box protein Pax-2a; Probable transcription factor involved in the development of the midbrain/hindbrain boundary (MHB) organizer and specification of neuronal cell fates. Required for establishment of eng2 and eng3 gene expression in the midbrain and MHB primordium during late gastrulation. (391 aa)
nr4a3Nuclear receptor subfamily 4, group A, member 3. (594 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues; Belongs to the nuclear hormone receptor family. NR3 subfamily. (569 aa)
abcg5ATP-binding cassette, sub-family G (WHITE), member 5. (652 aa)
srebf1Sterol regulatory element-binding transcription factor 1. (879 aa)
abcg1ATP-binding cassette, sub-family G (WHITE), member 1. (673 aa)
hmgcra3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
sirt1Sirtuin 1. (710 aa)
cyp8b1Cytochrome P450, family 8, subfamily B, polypeptide 1. (521 aa)
abcb11bATP-binding cassette, sub-family B (MDR/TAP), member 11b. (1308 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
nr4a2aNuclear receptor subfamily 4, group A, member 2a. (635 aa)
mycaTranscriptional regulator Myc-A; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (409 aa)
abcg8ATP-binding cassette, sub-family G (WHITE), member 8. (332 aa)
birc2Baculoviral IAP repeat-containing 2. (647 aa)
nr1d1Nuclear receptor subfamily 1, group d, member 1. (637 aa)
nr0b1Nuclear receptor subfamily 0, group B, member 1. (302 aa)
nr1i2Nuclear receptor subfamily 1, group I, member 2. (430 aa)
glb1Beta-galactosidase. (676 aa)
nos2aNitric oxide synthase; Produces nitric oxide (NO). (1079 aa)
nr2f2Drosophila seven-up homolog/mammalian ARP-1 homolog. (422 aa)
nr2e3Nuclear receptor subfamily 2, group E, member 3. (426 aa)
cyp19a1aAromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (517 aa)
insbInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (159 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of bax and fas antigen expression, or by repression of Bcl-2 expression. (369 aa)
nr2f1aNuclear receptor subfamily 2 group F member 1-A; Putative transcription factor that is required in photoreceptor cells precursors during eye development. Belongs to the nuclear hormone receptor family. NR2 subfamily. (411 aa)
A2BIK1_DANREBeta-galactosidase. (603 aa)
ncor1Nuclear receptor corepressor 1. (2398 aa)
bcl2aB-cell leukemia/lymphoma 2. (228 aa)
nr2c1Nuclear receptor subfamily 2, group C, member 1. (600 aa)
abca1aATP-binding cassette, sub-family A (ABC1), member 1A. (2268 aa)
hmgcrb3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1431 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
ctnnb1Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] (789 aa)
nr1h3Nuclear receptor subfamily 1, group H, member 3. (441 aa)
ccnd1G1/S-specific cyclin-D1; May play a role in transcriptional regulation (By similarity). Essential for the control of the cell cycle at the G1/S (start) transition. (291 aa)
nr5a2Nuclear receptor subfamily 5, group A, member 2. (517 aa)
esrraEstrogen-related receptor alpha. (436 aa)
esrrbEstrogen-related receptor beta. (437 aa)
nr6a1aNuclear receptor subfamily 6 group A member 1-A; Probable orphan nuclear receptor. Binds to a response element containing repeats of the motif 5'-AGGTCA-3' (By similarity). Belongs to the nuclear hormone receptor family. NR6 subfamily. (477 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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