node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LOC100334116 | acta1b | ENSDARP00000101310 | ENSDARP00000058628 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Actin alpha 1, skeletal muscle b. | 0.617 |
LOC100334116 | cdc42 | ENSDARP00000101310 | ENSDARP00000129339 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Cell division cycle 42. | 0.414 |
LOC100334116 | cdh1 | ENSDARP00000101310 | ENSDARP00000136579 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.726 |
LOC100334116 | ctnnb1 | ENSDARP00000101310 | ENSDARP00000139205 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.727 |
LOC100334116 | egf | ENSDARP00000101310 | ENSDARP00000069126 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Epidermal growth factor. | 0.852 |
LOC100334116 | egfra | ENSDARP00000101310 | ENSDARP00000125265 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Epidermal growth factor receptor precursor. | 0.736 |
LOC100334116 | eps15 | ENSDARP00000101310 | ENSDARP00000089463 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Epidermal growth factor receptor pathway substrate 15. | 0.514 |
LOC100334116 | met | ENSDARP00000101310 | ENSDARP00000123904 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | MET proto-oncogene, receptor tyrosine kinase. | 0.999 |
LOC100334116 | src | ENSDARP00000101310 | ENSDARP00000093618 | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | Proto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] | 0.827 |
acta1b | LOC100334116 | ENSDARP00000058628 | ENSDARP00000101310 | Actin alpha 1, skeletal muscle b. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.617 |
acta1b | cdc42 | ENSDARP00000058628 | ENSDARP00000129339 | Actin alpha 1, skeletal muscle b. | Cell division cycle 42. | 0.969 |
acta1b | cdh1 | ENSDARP00000058628 | ENSDARP00000136579 | Actin alpha 1, skeletal muscle b. | Cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. | 0.968 |
acta1b | ctnnb1 | ENSDARP00000058628 | ENSDARP00000139205 | Actin alpha 1, skeletal muscle b. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with axin1, axin2, apc, csnk1a1 and gsk3b that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of ctnnb1 and its subsequent degradation by the proteasome (By similarity). In the presence of Wnt ligand, ctnnb1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Plays a key role in dorso [...] | 0.967 |
acta1b | egf | ENSDARP00000058628 | ENSDARP00000069126 | Actin alpha 1, skeletal muscle b. | Epidermal growth factor. | 0.840 |
acta1b | egfra | ENSDARP00000058628 | ENSDARP00000125265 | Actin alpha 1, skeletal muscle b. | Epidermal growth factor receptor precursor. | 0.769 |
acta1b | eps15 | ENSDARP00000058628 | ENSDARP00000089463 | Actin alpha 1, skeletal muscle b. | Epidermal growth factor receptor pathway substrate 15. | 0.544 |
acta1b | hgfa | ENSDARP00000058628 | ENSDARP00000091725 | Actin alpha 1, skeletal muscle b. | Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. | 0.630 |
acta1b | met | ENSDARP00000058628 | ENSDARP00000123904 | Actin alpha 1, skeletal muscle b. | MET proto-oncogene, receptor tyrosine kinase. | 0.458 |
acta1b | pld2 | ENSDARP00000058628 | ENSDARP00000122561 | Actin alpha 1, skeletal muscle b. | Phospholipase. | 0.429 |
acta1b | podxl | ENSDARP00000058628 | ENSDARP00000093077 | Actin alpha 1, skeletal muscle b. | Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. | 0.631 |