node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
epha4a | robo2-2 | ENSDARP00000123962 | ENSDARP00000148113 | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | 0.531 |
epha4a | slit1a | ENSDARP00000123962 | ENSDARP00000105194 | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | Slit homolog 1a (Drosophila). | 0.511 |
epha4a | slit1b | ENSDARP00000123962 | ENSDARP00000150065 | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | Slit homolog 1b (Drosophila). | 0.477 |
epha4b | robo2-2 | ENSDARP00000030606 | ENSDARP00000148113 | Eph receptor A4b. | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | 0.494 |
epha4b | slit1a | ENSDARP00000030606 | ENSDARP00000105194 | Eph receptor A4b. | Slit homolog 1a (Drosophila). | 0.452 |
epha4b | slit1b | ENSDARP00000030606 | ENSDARP00000150065 | Eph receptor A4b. | Slit homolog 1b (Drosophila). | 0.444 |
gap43 | pou4f3 | ENSDARP00000136737 | ENSDARP00000124728 | Growth-associated protein 43. | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. | 0.860 |
gap43 | th | ENSDARP00000136737 | ENSDARP00000040409 | Growth-associated protein 43. | Tyrosine hydroxylase. | 0.622 |
hsp70l | pou4f3 | ENSDARP00000030050 | ENSDARP00000124728 | Novel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. | 0.588 |
pou4f3 | gap43 | ENSDARP00000124728 | ENSDARP00000136737 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. | Growth-associated protein 43. | 0.860 |
pou4f3 | hsp70l | ENSDARP00000124728 | ENSDARP00000030050 | POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. | Novel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. | 0.588 |
robo2-2 | epha4a | ENSDARP00000148113 | ENSDARP00000123962 | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | 0.531 |
robo2-2 | epha4b | ENSDARP00000148113 | ENSDARP00000030606 | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | Eph receptor A4b. | 0.494 |
robo2-2 | slit1a | ENSDARP00000148113 | ENSDARP00000105194 | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | Slit homolog 1a (Drosophila). | 0.998 |
robo2-2 | slit1b | ENSDARP00000148113 | ENSDARP00000150065 | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | Slit homolog 1b (Drosophila). | 0.998 |
robo2-2 | slit2 | ENSDARP00000148113 | ENSDARP00000026343 | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | Slit homolog 2 (Drosophila). | 0.985 |
slit1a | epha4a | ENSDARP00000105194 | ENSDARP00000123962 | Slit homolog 1a (Drosophila). | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | 0.511 |
slit1a | epha4b | ENSDARP00000105194 | ENSDARP00000030606 | Slit homolog 1a (Drosophila). | Eph receptor A4b. | 0.452 |
slit1a | robo2-2 | ENSDARP00000105194 | ENSDARP00000148113 | Slit homolog 1a (Drosophila). | Roundabout, axon guidance receptor, homolog 2 (Drosophila). | 0.998 |
slit1b | epha4a | ENSDARP00000150065 | ENSDARP00000123962 | Slit homolog 1b (Drosophila). | Ephrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] | 0.477 |