STRINGSTRING
robo2-2 robo2-2 slit1b slit1b slit2 slit2 hsp70l hsp70l epha4b epha4b th th slit1a slit1a epha4a epha4a pou4f3 pou4f3 cntn1a cntn1a gap43 gap43
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
robo2-2Roundabout, axon guidance receptor, homolog 2 (Drosophila). (136 aa)
slit1bSlit homolog 1b (Drosophila). (1532 aa)
slit2Slit homolog 2 (Drosophila). (1512 aa)
hsp70lNovel protein similar to heat shock cognate 70-kd protein; Belongs to the heat shock protein 70 family. (643 aa)
epha4bEph receptor A4b. (976 aa)
thTyrosine hydroxylase. (489 aa)
slit1aSlit homolog 1a (Drosophila). (1524 aa)
epha4aEphrin type-A receptor 4a; Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI- anchored ephrin-A and transmembrane ephrin-B ligands including efna1 and efnb3. [...] (995 aa)
pou4f3POU domain, class 4, transcription factor 3; Acts as a transcriptional activator. Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. May play a role in specifying terminally differentiated neuronal phenotypes. (331 aa)
cntn1aContactin-1a. (881 aa)
gap43Growth-associated protein 43. (194 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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