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prkd1 prkd1 ckba ckba prkacaa prkacaa prkd4 prkd4 dusp1 dusp1 hdac4 hdac4 pparg pparg prkd3 prkd3 sox6 sox6 prkd2 prkd2 ppardb ppardb myf5 myf5 ttn.1 ttn.1 myhz1.1 myhz1.1 nfatc4 nfatc4 cabin1 cabin1 hdac5 hdac5 tgfb5 tgfb5 ckmt2a ckmt2a mstnb mstnb sik1 sik1 prkacbb prkacbb srfa srfa mylpfa mylpfa tgfb1a tgfb1a ckmb ckmb acta1b acta1b ckmt2b ckmt2b atp2a1 atp2a1 myf6 myf6 mb mb ckma ckma six1b six1b gsk3ba gsk3ba tgfb3 tgfb3 ckbb ckbb prkacba prkacba ckmt1 ckmt1 myog myog myod1 myod1 myl1 myl1 prkacab prkacab Cabin1 Cabin1 nrf1 nrf1 eya1 eya1 igf3 igf3 znf106a znf106a eno3 eno3 tgfb1b tgfb1b pvalb7 pvalb7 pparda pparda
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prkd1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (886 aa)
ckbaCreatine kinase, brain a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
prkacaaProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (352 aa)
prkd4Zgc:175248 protein. (660 aa)
dusp1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (369 aa)
hdac4Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1023 aa)
ppargPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (116 aa)
prkd3Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (891 aa)
sox6SRY-box transcription factor 6. (816 aa)
prkd2Protein kinase D2. (562 aa)
ppardbPeroxisome proliferator-activated receptor delta b. (517 aa)
myf5Myogenic factor. (237 aa)
ttn.1Titin, tandem duplicate 1. (29152 aa)
myhz1.1Myosin, heavy polypeptide 1.1, skeletal muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
nfatc4Nuclear factor of-activated T cells 4. (865 aa)
cabin1Calcineurin-binding protein 1. (2200 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1128 aa)
tgfb5Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
ckmt2aCreatine kinase, mitochondrial 2a (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (417 aa)
mstnbGrowth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. (374 aa)
sik1Salt-inducible kinase 1. (811 aa)
prkacbbProtein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
srfaSerum response factor a. (539 aa)
mylpfaMyosin light chain, phosphorylatable, fast skeletal muscle a. (169 aa)
tgfb1aTransforming growth factor beta; Belongs to the TGF-beta family. (377 aa)
ckmbCreatine kinase, muscle b; Belongs to the ATP:guanido phosphotransferase family. (380 aa)
acta1bActin alpha 1, skeletal muscle b. (377 aa)
ckmt2bCreatine kinase, mitochondrial 2b (sarcomeric); Belongs to the ATP:guanido phosphotransferase family. (413 aa)
atp2a1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
myf6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (239 aa)
mbMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (147 aa)
ckmaCreatine kinase, muscle a; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
six1bHomeobox protein six1b; Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Depending on context, functions as transcriptional repressor or activator. Transcriptional activation is enhanced by eya1 (in vitro). Plays an important role in the development of the inner ear, where it promotes hair cell proliferation and inhibits proliferation of neural progenitor cells. Required for normal myogenesis. Plays a role in the development of fast muscle fibers throughout the body, as well as the development of craniofacial muscles. R [...] (284 aa)
gsk3baGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (410 aa)
ckbbBrain-subtype creatine kinase; Belongs to the ATP:guanido phosphotransferase family. (381 aa)
prkacbaProtein kinase, cAMP-dependent, catalytic, beta a; Belongs to the protein kinase superfamily. (395 aa)
ckmt1Creatine kinase, mitochondrial 1; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
myogMyogenin. (256 aa)
myod1Myoblast determination protein 1 homolog; May act as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. (275 aa)
myl1Myosin, light chain 1, alkali; skeletal, fast; Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function. (190 aa)
prkacabProtein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b; Belongs to the protein kinase superfamily. (351 aa)
Cabin1Si:ch73-313l22.2. (317 aa)
nrf1Nuclear respiratory factor 1; Probable transcription factor that is required for normal development of the outer retina. (504 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (609 aa)
igf3Insulin-like growth factor 3. (193 aa)
znf106aZinc finger protein 106a. (1636 aa)
eno3Enolase 3, (beta, muscle). (433 aa)
tgfb1bTransforming growth factor beta; Belongs to the TGF-beta family. (379 aa)
pvalb7Parvalbumin-7; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity). (109 aa)
ppardaPeroxisome proliferator-activated receptor delta a. (496 aa)
Your Current Organism:
Danio rerio
NCBI taxonomy Id: 7955
Other names: Brachydanio rerio, Brachydanio rerio frankei, Cyprinus rerio, D. rerio, Danio frankei, Danio rerio frankei, leopard danio, zebra danio, zebra fish, zebrafish
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